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Published in: Drugs & Aging 11/2006

01-11-2006 | Review Article

Risperidone for the Treatment of Neuropsychiatric Features in Dementia

Authors: Professor Alistair Burns, Peter P. De Deyn

Published in: Drugs & Aging | Issue 11/2006

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Abstract

Neuropsychiatric features of dementia are a common and significant burden on patients and their carers. Management usually involves a combination of pharmacological and non-pharmacological approaches. Antipsychotics are the cornerstone of treatment; among the atypical antipsychotics, risperidone is the most studied. Several trials have confirmed the efficacy of risperidone in the treatment of neuropsychiatric features in dementia, especially for agitation and psychosis. Recent concerns over an increased cerebrovascular adverse event profile and overall mortality with use of antipsychotics have emphasised the need for a risk-benefit analysis for individual demented patients being treated for neuropsychiatric features of their disease.
Literature
1.
go back to reference Hendrie HC. Epidemiology of dementia and Alzheimer’s disease. Am J Geriatr Psychiatry 1998; 6 (2 Suppl. 1): S3–18PubMed Hendrie HC. Epidemiology of dementia and Alzheimer’s disease. Am J Geriatr Psychiatry 1998; 6 (2 Suppl. 1): S3–18PubMed
2.
go back to reference Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer’s disease in a community population of older persons: higher than previously reported. JAMA 1989; 262: 2551–6PubMedCrossRef Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer’s disease in a community population of older persons: higher than previously reported. JAMA 1989; 262: 2551–6PubMedCrossRef
3.
go back to reference Hemels ME, Lanctot KL, Iskedjian M, et al. Clinical and economic factors in the treatment of behavioural and psychological symptoms of dementia. Drugs Aging 2001; 18: 527–50PubMedCrossRef Hemels ME, Lanctot KL, Iskedjian M, et al. Clinical and economic factors in the treatment of behavioural and psychological symptoms of dementia. Drugs Aging 2001; 18: 527–50PubMedCrossRef
4.
go back to reference Burns A, Jacoby R, Levy R. Psychiatric phenomena in Alzheimer’s disease. I: disorders of thought content. Br J Psychiatry 1990; 157: 72–94PubMedCrossRef Burns A, Jacoby R, Levy R. Psychiatric phenomena in Alzheimer’s disease. I: disorders of thought content. Br J Psychiatry 1990; 157: 72–94PubMedCrossRef
5.
go back to reference Cummings JL, Mega M, Gray K, et al. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308–14PubMedCrossRef Cummings JL, Mega M, Gray K, et al. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308–14PubMedCrossRef
6.
go back to reference Finkel SI, Costa e Silva J, Cohen G, et al. Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 1996; 8Suppl. 3: 497–500PubMed Finkel SI, Costa e Silva J, Cohen G, et al. Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 1996; 8Suppl. 3: 497–500PubMed
7.
go back to reference Jeste DV, Finkel SI. Psychosis of Alzheimer’s disease and related dementias: diagnostic criteria for a distinct syndrome. Am J Geriatr Psychiatry 2000; 8: 29–34PubMedCrossRef Jeste DV, Finkel SI. Psychosis of Alzheimer’s disease and related dementias: diagnostic criteria for a distinct syndrome. Am J Geriatr Psychiatry 2000; 8: 29–34PubMedCrossRef
8.
go back to reference Donaldson C, Tarder N, Burns A. The impact of the symptoms of dementia on caregivers. Br J Psychiatry 1997; 170: 62–8PubMedCrossRef Donaldson C, Tarder N, Burns A. The impact of the symptoms of dementia on caregivers. Br J Psychiatry 1997; 170: 62–8PubMedCrossRef
9.
go back to reference Burns A, Lawlor B, Craig S. Assessment scales in old age psychiatry. 2nd ed. London: Taylor & Francis, 2004 Burns A, Lawlor B, Craig S. Assessment scales in old age psychiatry. 2nd ed. London: Taylor & Francis, 2004
10.
go back to reference Reisberg B, Borenstein J, Salob SP, et al. Behavioral symptoms in Alzheimer’s disease: phenomenology and treatment. J Clin Psychiatry 1987 May; 48(Suppl. 5): 9–15PubMed Reisberg B, Borenstein J, Salob SP, et al. Behavioral symptoms in Alzheimer’s disease: phenomenology and treatment. J Clin Psychiatry 1987 May; 48(Suppl. 5): 9–15PubMed
11.
go back to reference Kaufer DI, Cummings JL, Ketchel P, et al. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci 2000; 12: 233–9PubMedCrossRef Kaufer DI, Cummings JL, Ketchel P, et al. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci 2000; 12: 233–9PubMedCrossRef
12.
go back to reference Cohen-Mansfield J. Conceptualization of agitation: results based on the Cohen-Mansfield agitation inventory and the agitation behavior mapping instrument. Int Psychogeriatr 1996; 8Suppl. 3: 309–15PubMed Cohen-Mansfield J. Conceptualization of agitation: results based on the Cohen-Mansfield agitation inventory and the agitation behavior mapping instrument. Int Psychogeriatr 1996; 8Suppl. 3: 309–15PubMed
13.
go back to reference Brodaty H, Draper B, Saab D, et al. Psychosis, depression and behavioural disturbances in Sydney nursing home residents: prevalence and predictors. Int J Geriatr Psychiatry 2001; 16: 504–12PubMedCrossRef Brodaty H, Draper B, Saab D, et al. Psychosis, depression and behavioural disturbances in Sydney nursing home residents: prevalence and predictors. Int J Geriatr Psychiatry 2001; 16: 504–12PubMedCrossRef
14.
go back to reference Ballard CG, Margallo-Lana M, Fossey J, et al. A 1-year follow-up study of behavioral and psychological symptoms in dementia among people in care environments. J Clin Psychiatry 2001; 62: 631–6PubMedCrossRef Ballard CG, Margallo-Lana M, Fossey J, et al. A 1-year follow-up study of behavioral and psychological symptoms in dementia among people in care environments. J Clin Psychiatry 2001; 62: 631–6PubMedCrossRef
15.
go back to reference Tractenberg RE, Weiner MF, Thal LJ. Estimating the prevalence of agitation in community-dwelling persons with Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 2002; 14: 11–8PubMedCrossRef Tractenberg RE, Weiner MF, Thal LJ. Estimating the prevalence of agitation in community-dwelling persons with Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 2002; 14: 11–8PubMedCrossRef
16.
go back to reference Haupt M, Kurz A, Janner M. A 2-year follow-up of behavioural and psychological symptoms in Alzheimer’s disease. Dement Geriatr Cogn Disord 2000; 11: 147–52PubMedCrossRef Haupt M, Kurz A, Janner M. A 2-year follow-up of behavioural and psychological symptoms in Alzheimer’s disease. Dement Geriatr Cogn Disord 2000; 11: 147–52PubMedCrossRef
17.
go back to reference Haupt M, Janner M, Ebeling S, et al. Presentation and stability of noncognitive symptom patterns in patients with Alzheimer disease. Alzheimer Dis Assoc Disord 1998; 12: 323–9PubMedCrossRef Haupt M, Janner M, Ebeling S, et al. Presentation and stability of noncognitive symptom patterns in patients with Alzheimer disease. Alzheimer Dis Assoc Disord 1998; 12: 323–9PubMedCrossRef
18.
go back to reference Rapoport MJ, van Reekum R, Freedman M, et al. Relationship of psychosis to aggression, apathy and function in dementia. Int J Geriatr Psychiatry 2001; 16: 123–30PubMedCrossRef Rapoport MJ, van Reekum R, Freedman M, et al. Relationship of psychosis to aggression, apathy and function in dementia. Int J Geriatr Psychiatry 2001; 16: 123–30PubMedCrossRef
19.
go back to reference Engelborghs S, Maertens K, Nagels G, et al. Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study. Int J Geriatr Psychiatry 2005; 20: 1028–37PubMedCrossRef Engelborghs S, Maertens K, Nagels G, et al. Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study. Int J Geriatr Psychiatry 2005; 20: 1028–37PubMedCrossRef
20.
go back to reference Lawton MP. Assessing quality of life in Alzheimer disease research. Alzheimer Dis Assoc Disord 1997; 11Suppl. 6: 91–9PubMed Lawton MP. Assessing quality of life in Alzheimer disease research. Alzheimer Dis Assoc Disord 1997; 11Suppl. 6: 91–9PubMed
21.
go back to reference Tarrier N, Barrowclough C, Ward J, et al. Expressed emotion and attributions in the carers of patients with Alzheimer’s disease: the effect on carer burden. J Abnorm Psychol 2002; 111: 340–9PubMedCrossRef Tarrier N, Barrowclough C, Ward J, et al. Expressed emotion and attributions in the carers of patients with Alzheimer’s disease: the effect on carer burden. J Abnorm Psychol 2002; 111: 340–9PubMedCrossRef
22.
go back to reference Tariot PN. Clinical effectiveness of atypical antipsychotics in dementia. J Clin Psychiatry 2004; 65Suppl. 11: 3–4PubMed Tariot PN. Clinical effectiveness of atypical antipsychotics in dementia. J Clin Psychiatry 2004; 65Suppl. 11: 3–4PubMed
23.
24.
go back to reference Snowden M, Sato K, Roy-Byrne P. Assessment and treatment of nursing home residents with depression or behavioral symptoms associated with dementia: a review of the literature. J Am Geriatr Soc 2003; 51: 1305–17PubMedCrossRef Snowden M, Sato K, Roy-Byrne P. Assessment and treatment of nursing home residents with depression or behavioral symptoms associated with dementia: a review of the literature. J Am Geriatr Soc 2003; 51: 1305–17PubMedCrossRef
25.
go back to reference Schneider LS, Pollock VE, Lyness SA. A meta analysis of controlled trials of neuroleptic treatment in dementia. J Am Geriatr Soc 1990; 38: 553–63PubMed Schneider LS, Pollock VE, Lyness SA. A meta analysis of controlled trials of neuroleptic treatment in dementia. J Am Geriatr Soc 1990; 38: 553–63PubMed
26.
go back to reference Jeste DV, Rockwell E, Harris MJ, et al. Conventional vs. newer antipsychotics in elderly patients. Am J Geriatr Psychiatry 1999; 7: 70–6PubMed Jeste DV, Rockwell E, Harris MJ, et al. Conventional vs. newer antipsychotics in elderly patients. Am J Geriatr Psychiatry 1999; 7: 70–6PubMed
27.
go back to reference Mintzer J, Burns A. Anticholinergic side-effects of drugs in elderly people. J R Soc Med 2000; 93: 457–62PubMed Mintzer J, Burns A. Anticholinergic side-effects of drugs in elderly people. J R Soc Med 2000; 93: 457–62PubMed
28.
go back to reference Zaudig M. A risk-benefit assessment of risperidone for the treatment of behavioural and psychological symptoms in dementia. Drug Saf 2000; 23: 183–95PubMedCrossRef Zaudig M. A risk-benefit assessment of risperidone for the treatment of behavioural and psychological symptoms in dementia. Drug Saf 2000; 23: 183–95PubMedCrossRef
29.
go back to reference McShane R, Keene J, Gedling K, et al. Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up. BMJ 1997; 314: 266–70PubMedCrossRef McShane R, Keene J, Gedling K, et al. Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up. BMJ 1997; 314: 266–70PubMedCrossRef
30.
go back to reference Lawlor B, Bhriain SN. Psychosis and behavioural symptoms of dementia: defining the role of neuroleptic interventions. Int J Geriatr Psychiatry 2001; 16Suppl. 1: S2–6PubMedCrossRef Lawlor B, Bhriain SN. Psychosis and behavioural symptoms of dementia: defining the role of neuroleptic interventions. Int J Geriatr Psychiatry 2001; 16Suppl. 1: S2–6PubMedCrossRef
31.
go back to reference De Deyn PP, Rabheru K, Rasmussen A, et al. A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia. Neurology 1999; 53: 946–55PubMedCrossRef De Deyn PP, Rabheru K, Rasmussen A, et al. A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia. Neurology 1999; 53: 946–55PubMedCrossRef
32.
go back to reference Liperoti R, Mor V, Lapane KL, et al. The use of atypical antipsychotics in nursing homes. J Clin Psychiatry 2003; 64: 1106–12PubMedCrossRef Liperoti R, Mor V, Lapane KL, et al. The use of atypical antipsychotics in nursing homes. J Clin Psychiatry 2003; 64: 1106–12PubMedCrossRef
33.
go back to reference Alexopoulos GS, Jeste DV, Chung H, et al. The Expert Consensus Guideline Series: treatment of dementia and its behavioral disturbances. Postgrad Med Special Report 2005 Jan: 1–111 Alexopoulos GS, Jeste DV, Chung H, et al. The Expert Consensus Guideline Series: treatment of dementia and its behavioral disturbances. Postgrad Med Special Report 2005 Jan: 1–111
34.
go back to reference Greve M, O’Connor D. A survey of Australian and New Zealand old age psychiatrists’ preferred medications to treat behavioural and psychological symptoms of dementia (BPSD). Int Psychogeriatr 2005; 17: 195–205PubMedCrossRef Greve M, O’Connor D. A survey of Australian and New Zealand old age psychiatrists’ preferred medications to treat behavioural and psychological symptoms of dementia (BPSD). Int Psychogeriatr 2005; 17: 195–205PubMedCrossRef
35.
go back to reference Katz IR, Jeste DV, Mintzer JE, et al. Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. Risperidone Study Group. J Clin Psychiatry 1999; 60: 107–15PubMedCrossRef Katz IR, Jeste DV, Mintzer JE, et al. Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. Risperidone Study Group. J Clin Psychiatry 1999; 60: 107–15PubMedCrossRef
36.
go back to reference Street JS, Clark WS, Gannon KS, et al. Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities: a double-blind, randomized, placebo-controlled trial. The HGEU Study Group. Arch Gen Psychiatry 2000; 57: 968–76PubMedCrossRef Street JS, Clark WS, Gannon KS, et al. Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities: a double-blind, randomized, placebo-controlled trial. The HGEU Study Group. Arch Gen Psychiatry 2000; 57: 968–76PubMedCrossRef
37.
go back to reference Brodaty H, Ames D, Snowdon J, et al. A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J Clin Psychiatry 2003; 64: 134–43PubMedCrossRef Brodaty H, Ames D, Snowdon J, et al. A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J Clin Psychiatry 2003; 64: 134–43PubMedCrossRef
38.
go back to reference Schneider LS, Tariot PN, Lyketsos CG, et al. National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer disease trial methodology. Am J Geriatr Psychiatry 2001; 9: 346–60PubMed Schneider LS, Tariot PN, Lyketsos CG, et al. National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer disease trial methodology. Am J Geriatr Psychiatry 2001; 9: 346–60PubMed
39.
go back to reference Risperdal® (risperidone) [package insert]. Titusville (NJ): Janssen Pharmaceutica Products LP, 2005 May Risperdal® (risperidone) [package insert]. Titusville (NJ): Janssen Pharmaceutica Products LP, 2005 May
40.
go back to reference Chan WC, Lam LC, Choy CN, et al. A double-blind randomised comparison of risperidone and haloperidol in the treatment of behavioural and psychological symptoms in Chinese dementia patients. Int J Geriatr Psychiatry 2001; 16: 1156–62PubMedCrossRef Chan WC, Lam LC, Choy CN, et al. A double-blind randomised comparison of risperidone and haloperidol in the treatment of behavioural and psychological symptoms in Chinese dementia patients. Int J Geriatr Psychiatry 2001; 16: 1156–62PubMedCrossRef
41.
go back to reference Rainer MK, Masching AJ, Ertl MG, et al. Effect of risperidone on behavioral and psychological symptoms and cognitive function in dementia. J Clin Psychiatry 2001; 62: 894–900PubMedCrossRef Rainer MK, Masching AJ, Ertl MG, et al. Effect of risperidone on behavioral and psychological symptoms and cognitive function in dementia. J Clin Psychiatry 2001; 62: 894–900PubMedCrossRef
42.
go back to reference Laks J, Engelhardt E, Marinho V, et al. Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly. Arq Neuropsiquiatr 2001; 59: 859–64PubMedCrossRef Laks J, Engelhardt E, Marinho V, et al. Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly. Arq Neuropsiquiatr 2001; 59: 859–64PubMedCrossRef
43.
go back to reference Lavretsky H, Sultzer D. A structured trial of risperidone for the treatment of agitation in dementia. Am J Geriatr Psychiatry 1998; 6: 127–35PubMed Lavretsky H, Sultzer D. A structured trial of risperidone for the treatment of agitation in dementia. Am J Geriatr Psychiatry 1998; 6: 127–35PubMed
44.
go back to reference Frenchman IB, Prince T. Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances. Int Psychogeriatr 1997; 9: 431–5PubMedCrossRef Frenchman IB, Prince T. Clinical experience with risperidone, haloperidol, and thioridazine for dementia-associated behavioral disturbances. Int Psychogeriatr 1997; 9: 431–5PubMedCrossRef
45.
go back to reference Irizarry MC, Ghaemi SN, Lee-Cherry ER, et al. Risperidone treatment of behavioral disturbances in outpatients with dementia. J Neuropsychiatry Clin Neurosci 1999; 11: 336–42PubMed Irizarry MC, Ghaemi SN, Lee-Cherry ER, et al. Risperidone treatment of behavioral disturbances in outpatients with dementia. J Neuropsychiatry Clin Neurosci 1999; 11: 336–42PubMed
46.
go back to reference Yoon JS, Kim JM, Lee H, et al. Risperidone use in Korean patients with Alzheimer’s disease: optimal dosage and effect on behavioural and psychological symptoms, cognitive function and activities of daily living. Hum Psychopharmacol 2003; 18: 627–33PubMedCrossRef Yoon JS, Kim JM, Lee H, et al. Risperidone use in Korean patients with Alzheimer’s disease: optimal dosage and effect on behavioural and psychological symptoms, cognitive function and activities of daily living. Hum Psychopharmacol 2003; 18: 627–33PubMedCrossRef
47.
go back to reference Jeste DV, Okamoto A, Napolitano J, et al. Low incidence of persistent tardive dyskinesia in elderly patients with dementia treated with risperidone. Am J Psychiatry 2000; 157: 1150–5PubMedCrossRef Jeste DV, Okamoto A, Napolitano J, et al. Low incidence of persistent tardive dyskinesia in elderly patients with dementia treated with risperidone. Am J Psychiatry 2000; 157: 1150–5PubMedCrossRef
48.
go back to reference De Deyn PP, Katz IR, Brodaty H, et al. Management of agitation, aggression, and psychosis associated with dementia: a pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone. Clin Neurol Neurosurg 2005; 107: 497–508PubMedCrossRef De Deyn PP, Katz IR, Brodaty H, et al. Management of agitation, aggression, and psychosis associated with dementia: a pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone. Clin Neurol Neurosurg 2005; 107: 497–508PubMedCrossRef
49.
go back to reference Mintzer J, Greenspan A, Caers I, et al. Risperidone in the treatment of psychosis of Alzheimer’s disease: results from a prospective clinical trial. Am J Geriatr Psychiatry 2006; 14: 280–91PubMedCrossRef Mintzer J, Greenspan A, Caers I, et al. Risperidone in the treatment of psychosis of Alzheimer’s disease: results from a prospective clinical trial. Am J Geriatr Psychiatry 2006; 14: 280–91PubMedCrossRef
50.
go back to reference Wooltorton E. Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials. CMAJ 2002; 167: 1269–70PubMed Wooltorton E. Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials. CMAJ 2002; 167: 1269–70PubMed
51.
go back to reference Suh GH, Son HG, Ju YS, et al. A randomized, double-blind, crossover comparison of risperidone and haloperidol in Korean dementia patients with behavioral disturbances. Am J Geriatr Psychiatry 2004; 12: 509–16PubMed Suh GH, Son HG, Ju YS, et al. A randomized, double-blind, crossover comparison of risperidone and haloperidol in Korean dementia patients with behavioral disturbances. Am J Geriatr Psychiatry 2004; 12: 509–16PubMed
52.
go back to reference De Deyn PP, Wirshing WC. Scales to assess efficacy and safety of pharmacologic agents in the treatment of behavioral and psychological symptoms of dementia. J Clin Psychiatry 2001; 62Suppl. 21: 19–22PubMed De Deyn PP, Wirshing WC. Scales to assess efficacy and safety of pharmacologic agents in the treatment of behavioral and psychological symptoms of dementia. J Clin Psychiatry 2001; 62Suppl. 21: 19–22PubMed
53.
go back to reference Goldberg RJ, Goldberg J. Risperidone for dementia-related disturbed behavior in nursing home residents: a clinical experience. Int Psychogeriatr 1997; 9: 65–8PubMedCrossRef Goldberg RJ, Goldberg J. Risperidone for dementia-related disturbed behavior in nursing home residents: a clinical experience. Int Psychogeriatr 1997; 9: 65–8PubMedCrossRef
54.
go back to reference Arriola E, Diago JI. Treatment with risperidone: positive impact on patients with BPSD and caregiver stress. Am J Geriatr Pharmacother 2005; 3: 8–16PubMedCrossRef Arriola E, Diago JI. Treatment with risperidone: positive impact on patients with BPSD and caregiver stress. Am J Geriatr Pharmacother 2005; 3: 8–16PubMedCrossRef
55.
go back to reference Wancata J. Efficacy of risperidone for treating patients with behavioral and psychological symptoms of dementia. Int Psychogeriatr 2004; 16: 107–15PubMedCrossRef Wancata J. Efficacy of risperidone for treating patients with behavioral and psychological symptoms of dementia. Int Psychogeriatr 2004; 16: 107–15PubMedCrossRef
56.
go back to reference Schwalen S, Kurz A. Risperidone for the treatment of behavioural disorders in dementia. Nervenheilkunde 2002; 21: 208–13 Schwalen S, Kurz A. Risperidone for the treatment of behavioural disorders in dementia. Nervenheilkunde 2002; 21: 208–13
57.
go back to reference Shigenobu K, Ikeda M, Fukuhara R, et al. Reducing the burden of caring for Alzheimer’s disease through the amelioration of “delusions of theft” by drug therapy. Int J Geriatr Psychiatry 2002; 17: 211–7PubMedCrossRef Shigenobu K, Ikeda M, Fukuhara R, et al. Reducing the burden of caring for Alzheimer’s disease through the amelioration of “delusions of theft” by drug therapy. Int J Geriatr Psychiatry 2002; 17: 211–7PubMedCrossRef
58.
go back to reference Lane HY, Chang YC, Su MH, et al. Shifting from haloperidol to risperidone for behavioral disturbances in dementia: safety, response predictors, and mood effects. J Clin Psychopharmacol 2002; 22: 4–10PubMedCrossRef Lane HY, Chang YC, Su MH, et al. Shifting from haloperidol to risperidone for behavioral disturbances in dementia: safety, response predictors, and mood effects. J Clin Psychopharmacol 2002; 22: 4–10PubMedCrossRef
59.
go back to reference De Deyn PP, Katz IR. Control of aggression and agitation in patients with dementia: efficacy and safety of risperidone. Int J Geriatr Psychiatry 2000; 15Suppl. 1: S14–22PubMed De Deyn PP, Katz IR. Control of aggression and agitation in patients with dementia: efficacy and safety of risperidone. Int J Geriatr Psychiatry 2000; 15Suppl. 1: S14–22PubMed
60.
go back to reference Alexopoulos GS, Streim J, Carpenter D, et al. Using antipsychotic agents in older patients. J Clin Psychiatry 2004; 65Suppl. 2: 5–99PubMed Alexopoulos GS, Streim J, Carpenter D, et al. Using antipsychotic agents in older patients. J Clin Psychiatry 2004; 65Suppl. 2: 5–99PubMed
61.
go back to reference Ananth J, Parameswaran S, Gunatilake S, et al. Neuroleptic malignant syndrome and atypical antipsychotic drugs. J Clin Psychiatry 2004; 65: 464–70PubMedCrossRef Ananth J, Parameswaran S, Gunatilake S, et al. Neuroleptic malignant syndrome and atypical antipsychotic drugs. J Clin Psychiatry 2004; 65: 464–70PubMedCrossRef
62.
go back to reference Mion LC, Gregor S, Buettner M, et al. Falls in the rehabilitation setting: incidence and characteristics [published erratum appears in Rehabil Nurs 1989; 14: 133]. Rehabil Nurs 1989; 14: 17–22PubMedCrossRef Mion LC, Gregor S, Buettner M, et al. Falls in the rehabilitation setting: incidence and characteristics [published erratum appears in Rehabil Nurs 1989; 14: 133]. Rehabil Nurs 1989; 14: 17–22PubMedCrossRef
63.
go back to reference Kiely DK, Kiel DP, Burrows AB, et al. Identifying nursing home residents at risk for falling. J Am Geriatr Soc 1998; 46: 551–5PubMed Kiely DK, Kiel DP, Burrows AB, et al. Identifying nursing home residents at risk for falling. J Am Geriatr Soc 1998; 46: 551–5PubMed
64.
go back to reference Marx MS, Cohen-Mansfield J, Werner P. Agitation and falls in institutionalized elderly persons. J Appl Gerontol 1990; 9: 106–17PubMedCrossRef Marx MS, Cohen-Mansfield J, Werner P. Agitation and falls in institutionalized elderly persons. J Appl Gerontol 1990; 9: 106–17PubMedCrossRef
65.
go back to reference Katz IR, Rupnow M, Kozma C, et al. Risperidone and falls in ambulatory nursing home residents with dementia and psychosis or agitation: secondary analysis of a double-blind, placebo-controlled trial. Am J Geriatr Psychiatry 2004; 12: 499–508PubMed Katz IR, Rupnow M, Kozma C, et al. Risperidone and falls in ambulatory nursing home residents with dementia and psychosis or agitation: secondary analysis of a double-blind, placebo-controlled trial. Am J Geriatr Psychiatry 2004; 12: 499–508PubMed
66.
go back to reference Martin H, Slyk MP, Deymann S, et al. Safety profile assessment of risperidone and olanzapine in long-term care patients with dementia [published erratum appears in J Am Med Dir Assoc 2003; 4: 290]. J Am Med Dir Assoc 2003; 4: 183–8PubMedCrossRef Martin H, Slyk MP, Deymann S, et al. Safety profile assessment of risperidone and olanzapine in long-term care patients with dementia [published erratum appears in J Am Med Dir Assoc 2003; 4: 290]. J Am Med Dir Assoc 2003; 4: 183–8PubMedCrossRef
67.
go back to reference Greenspan A, Eerdekens M, Mahmoud R. Risk of cerebrovascular adverse events, including mortality, with risperidone in elderly patients. Int Psychogeriatr 2003; PB-041Suppl. 2: 261–2 Greenspan A, Eerdekens M, Mahmoud R. Risk of cerebrovascular adverse events, including mortality, with risperidone in elderly patients. Int Psychogeriatr 2003; PB-041Suppl. 2: 261–2
68.
go back to reference Wooltorton E. Olanzapine (Zyprexa): increased incidence of cerebrovascular events in dementia trials. CMAJ 2004; 170: 1395PubMedCrossRef Wooltorton E. Olanzapine (Zyprexa): increased incidence of cerebrovascular events in dementia trials. CMAJ 2004; 170: 1395PubMedCrossRef
71.
go back to reference Gill SS, Rochon PA, Herrmann N, et al. Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study. BMJ 2005; 330: 445PubMedCrossRef Gill SS, Rochon PA, Herrmann N, et al. Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study. BMJ 2005; 330: 445PubMedCrossRef
72.
go back to reference Finkel S, Kozma C, Long S, et al. Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics. Int Psychogeriatr 2005; 17: 617–29PubMedCrossRef Finkel S, Kozma C, Long S, et al. Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics. Int Psychogeriatr 2005; 17: 617–29PubMedCrossRef
73.
go back to reference Herrmann N, Mamdani M, Lanctot KL. Atypical antipsychotics and risk of cerebrovascular accidents. Am J Psychiatry 2004; 161: 1113–5PubMedCrossRef Herrmann N, Mamdani M, Lanctot KL. Atypical antipsychotics and risk of cerebrovascular accidents. Am J Psychiatry 2004; 161: 1113–5PubMedCrossRef
75.
go back to reference Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005; 294: 1934–43PubMedCrossRef Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005; 294: 1934–43PubMedCrossRef
76.
go back to reference Wang PS, Schneeweiss S, Avorn J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med 2005; 353: 2335–41PubMedCrossRef Wang PS, Schneeweiss S, Avorn J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med 2005; 353: 2335–41PubMedCrossRef
77.
go back to reference Katz IR, Brodaty H, De Deyn PP, et al. Risperidone in the treatment of psychosis of Alzheimer’s disease (PAD): a pooled analysis of 4 controlled trials. Poster presented at the annual scientific meeting of the American Geriatrics Society (AGS); 2005 May 11–15; Orlando (Florida), USA Katz IR, Brodaty H, De Deyn PP, et al. Risperidone in the treatment of psychosis of Alzheimer’s disease (PAD): a pooled analysis of 4 controlled trials. Poster presented at the annual scientific meeting of the American Geriatrics Society (AGS); 2005 May 11–15; Orlando (Florida), USA
78.
go back to reference Lee PE, Gill SS, Freedman M, et al. Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review. BMJ 2004; 329: 75–9PubMedCrossRef Lee PE, Gill SS, Freedman M, et al. Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review. BMJ 2004; 329: 75–9PubMedCrossRef
Metadata
Title
Risperidone for the Treatment of Neuropsychiatric Features in Dementia
Authors
Professor Alistair Burns
Peter P. De Deyn
Publication date
01-11-2006
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 11/2006
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.2165/00002512-200623110-00004

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