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World Journal of Surgery

Published in:

01-09-2008

Risk Factors for Lymph Node Metastasis in Submucosal Invasive Colorectal Cancer

Authors: Pyong W. Choi, Chang Sik Yu, Se J. Jang, Sang H. Jung, Hee C. Kim, Jin C. Kim

Published in: World Journal of Surgery | Issue 9/2008

Abstract

Background

Recent studies have shown a 7–15% lymph node (LN) metastasis rate in submucosal invasive colorectal cancer (SICC). Identifying risk factors for LN metastasis is crucial in selecting therapeutic modalities for SICC. We assessed the possibility of and the risk factors for LN metastasis in SICC.

Methods

We performed a retrospective study on 168 SICC patients who underwent curative resection between June 1989 and December 2004 at Asan Medical Center. The level of submucosal invasion was classified into upper third (sm1), middle third (sm2), and lower third (sm3). The following carcinoma-related variables were assessed: tumor size, tumor location, depth of submucosal invasion, cell differentiation, lymphovascular invasion, neural invasion, and tumor cell dissociation (TCD).

Results

The overall LN metastasis rate was 14.3%. Significant predictors of LN metastasis both univariately and multivariately were sm3 (p = 0.039), poorly differentiated cancer (p = 0.028), and TCD (p = 0.045). Lymphovascular invasion was a risk factor for LN metastasis in univariate analysis (p = 0.019); however, in multivariate analysis, lymphovascular invasion could not predict LN metastasis. No statistical difference was observed in the risk of LN metastasis with regard to tumor location, size, and neural invasion.

Conclusion

The depth of submucosal invasion, cell differentiation, and tumor cell dissociation were significant pathologic predictors of LN metastasis in SICC. Because SICC is associated with a considerable risk of LN metastasis, local excision may be performed carefully in SICC without adverse features.

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Title: Risk Factors for Lymph Node Metastasis in Submucosal Invasive Colorectal Cancer
Authors: Pyong W. Choi
Chang Sik Yu
Se J. Jang
Sang H. Jung
Hee C. Kim
Jin C. Kim
Publication date: 01-09-2008
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 9/2008
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-008-9628-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk Factors for Lymph Node Metastasis in Submucosal Invasive Colorectal Cancer

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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