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Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 6/2005

01-06-2005

Curative Resection of T1 Colorectal Carcinoma: Risk of Lymph Node Metastasis and Long-Term Prognosis

Authors: Huann-Sheng Wang, M.D., Wen-Yih Liang, M.D., Tzu-Chen Lin, M.D., Wei-Shone Chen, M.D., Ph.D., Jeng-Kae Jiang, M.D., Ph.D., Shung-Haur Yang, M.D., Ph.D., Shih-Ching Chang, M.D., Jen-Kou Lin, M.D., Ph.D.

Published in: Diseases of the Colon & Rectum | Issue 6/2005

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PURPOSE

The features of T1 colorectal adenocarcinoma and the risk determination of lymph node metastasis were reviewed. Prognostic factors were assessed to verify whether the risk of lymph node metastasis would influence the long-term prognosis.

METHODS

Patients undergoing curative resection of T1 colorectal adenocarcinoma at the Taipei Veterans General Hospital from December 1969 to August 2002 were retrospectively studied. Patients with synchronous colorectal cancer, distant metastasis, familiar adenomatous polyposis, or inflammatory bowel disease were excluded. The associations between lymph node metastasis and clinicopathologic variables were evaluated univariately using chi-squared test, Fisher’s exact test, or Student’s t -test, and multivariately using logistic regression. Univariate analysis by the log-rank test and multivariate analysis by Cox regression hazards model determined the factors influencing the overall survival.

RESULTS

A total of 159 patients were included. Sixteen patients (10.1 percent) had lymph node metastasis. The risk of lymph node metastasis included histologic grade (P = 0.005), lymphatic vessel invasion (P = 0.023), inflammation around cancer (P = 0.049), and budding at the invasive front of tumor (P = 0.022). Age (P = 0.001) and number of total sampling lymph nodes (P < 0.0001) were found to be the factors influencing the overall survival.

CONCLUSIONS

Variables that predict lymph node metastasis in surgically resected T1 colorectal carcinoma may not impact the long-term prognosis.
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Metadata
Title
Curative Resection of T1 Colorectal Carcinoma: Risk of Lymph Node Metastasis and Long-Term Prognosis
Authors
Huann-Sheng Wang, M.D.
Wen-Yih Liang, M.D.
Tzu-Chen Lin, M.D.
Wei-Shone Chen, M.D., Ph.D.
Jeng-Kae Jiang, M.D., Ph.D.
Shung-Haur Yang, M.D., Ph.D.
Shih-Ching Chang, M.D.
Jen-Kou Lin, M.D., Ph.D.
Publication date
01-06-2005
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 6/2005
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-004-0935-y

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