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Journal of Cardiovascular Translational Research

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01-10-2019 | Original Article

Right Ventricular Function After Pulmonary Artery Banding: Adaptive Processes Assessed by CMR and Conductance Catheter Measurements in Sheep

Authors: Hubert Gufler, Sabine Niefeldt, Johannes Boltze, Stephanie Prietz, Christian Klopsch, Sabine Wagner, Brigitte Vollmar, Can Yerebakan

Published in: Journal of Cardiovascular Translational Research | Issue 5/2019

Abstract

This experimental study describes the adaptive processes of the right ventricular (RV) myocardium after pulmonary artery banding (PAB) evaluated by cine cardiac magnetic resonance (CMR), phase-contrast CMR (PC-CMR), and conductance catheter. Seven sheep were subjected to CMR 3 months after PAB. Conductance catheter measurements were performed before and 3 months after PAB. Four nonoperated, healthy, age-matched animals served as controls. Higher RV masses (p < 0.01), elevated RV end-systolic volumes (p < 0.05), and lower RV ejection fraction (p < 0.01) were observed in the operated group. The time-to-peak pulmonary artery flow was longer in the banding group (p < 0.01). RV maximal pressure and RV end-diastolic pressure correlated with the time-to-peak flow in the pulmonary artery (r = − 0.70 and − 0.69, respectively). In summary, PAB caused RV hypertrophy, increased myocardial contractility, and decreased RV-EF and cardiac output. The time-to-peak pulmonary artery flow correlated with RV pressures.

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Title: Right Ventricular Function After Pulmonary Artery Banding: Adaptive Processes Assessed by CMR and Conductance Catheter Measurements in Sheep
Authors: Hubert Gufler
Sabine Niefeldt
Johannes Boltze
Stephanie Prietz
Christian Klopsch
Sabine Wagner
Brigitte Vollmar
Can Yerebakan
Publication date: 01-10-2019
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 5/2019
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-019-09881-6

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Right Ventricular Function After Pulmonary Artery Banding: Adaptive Processes Assessed by CMR and Conductance Catheter Measurements in Sheep

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