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Clinical Rheumatology
Published in: Clinical Rheumatology 9/2015

01-09-2015 | Case Based Review

Rheumatologic manifestations of the “MonoMAC” syndrome. a systematic review

Authors: Jennifer A. Johnson, Steven S. Yu, Michael Elist, Daniel Arkfeld, Richard S. Panush

Published in: Clinical Rheumatology | Issue 9/2015

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Abstract

MonoMAC syndrome is characterized by monocytopenia with susceptibility to nontuberculous mycobacterial infections. First recognized in 2011, it is caused by GATA2 mutations and can manifest as disseminated mycobacterial, fungal, and viral infections. While mortality rates for this disorder have been high, it has recently been successfully treated with haploidentical allogeneic stem cell transplant. Since approximately one third of patients may have rheumatologic symptoms, such as erythema nodosum, panniculitis, or arthralgias, rheumatologists may expect to encounter this newly described entity with increasing frequency.
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Metadata
Title
Rheumatologic manifestations of the “MonoMAC” syndrome. a systematic review
Authors
Jennifer A. Johnson
Steven S. Yu
Michael Elist
Daniel Arkfeld
Richard S. Panush
Publication date
01-09-2015
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 9/2015
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-015-2905-2

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