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09-04-2024 | Rheumatoid Arthritis | Note

New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells

Authors: Kazuki Fujii, Itsuki Iwata, Akiko Takaya, Masami Ishibashi, Yasumasa Hara

Published in: Journal of Natural Medicines | Issue 3/2024

Abstract

Three new biflavonoids (1–3) and two known flavonoids (4, 5) were isolated from Xylia kerrii collected in Thailand. Compounds 1–5 showed selective cytotoxicity against the rheumatoid fibroblast-like synovial MH7A cell line, and these compounds showed weak cytotoxicity against the human lung synovial fibroblast WI-38 VA13 sub 2 RA cell line. Notably, compound 1 was highly selective toward MH7A cells with an IC₅₀ value of 6.9 μM, whereas the IC₅₀ value for WI-38 VA13 sub 2 RA cells was > 100 μM. The western blotting analysis of MH7A cells treated with compound 1 showed increased CDKN2A /p16INK4A and caspase-8 levels.

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Title: New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells
Authors: Kazuki Fujii
Itsuki Iwata
Akiko Takaya
Masami Ishibashi
Yasumasa Hara
Publication date: 09-04-2024
Publisher: Springer Nature Singapore
Keyword: Rheumatoid Arthritis
Published in: Journal of Natural Medicines / Issue 3/2024
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01801-6

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New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells

Abstract

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Graphical abstract

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