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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-08-2016 | Original Article

RGD-K5 PET/CT in patients with advanced head and neck cancer treated with concurrent chemoradiotherapy: Results from a pilot study

Authors: Shih-Hsin Chen, Hung-Ming Wang, Chien-Yu Lin, Joseph Tung-Chieh Chang, Chia-Hsun Hsieh, Chun-Ta Liao, Chung-Jan Kang, Lan-Yan Yang, Tzu-Chen Yen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2016

Abstract

Background/Aim

We prospectively investigated the potential usefulness of PET using a new tracer targeting integrin αvβ3 (termed RGD-K5) in patients with head and neck cancer (HNC) undergoing definitive concurrent chemoradiotherapy (CCRT).

Patients and Methods

Newly diagnosed patients with locally advanced HNC scheduled for definitive CCRT were eligible. RDG-K5 PET and FDG PET scans were performed at three different time points (baseline, 2 weeks, and 3 months post-treatment).

Results

Nine patients completed all of the three scans, whereas two patients withdrew after two scans only. Uptake of both RGD-K5 and FDG generally decreased following CCRT. However, the observed decrease did not differ significantly between complete responders and non-responders. At 3 months post-treatment, the uptake of both RGD-K5 and FDG at the main tumors was significantly lower in those who achieved complete responses than in those with residual tumors.

Conclusion

RGD-K5 PET has the potential to identify patients with incomplete responses to CCRT.

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Title: RGD-K5 PET/CT in patients with advanced head and neck cancer treated with concurrent chemoradiotherapy: Results from a pilot study
Authors: Shih-Hsin Chen
Hung-Ming Wang
Chien-Yu Lin
Joseph Tung-Chieh Chang
Chia-Hsun Hsieh
Chun-Ta Liao
Chung-Jan Kang
Lan-Yan Yang
Tzu-Chen Yen
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-016-3345-1

2024 ASCO Annual Meeting

Springer Medicine

RGD-K5 PET/CT in patients with advanced head and neck cancer treated with concurrent chemoradiotherapy: Results from a pilot study

Abstract

Background/Aim

Patients and Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background/Aim

Patients and Methods

Results

Conclusion

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