Published in:
01-01-2014 | Original Paper
Retrospective study of neuroblastoma in Chinese neonates from 1994 to 2011: an evaluation of diagnosis, treatments, and prognosis
A 10-year restrospective study of neonatal neuroblastoma
Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2014
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Purpose
The purpose of the study is to review the clinical features, treatments, and outcomes of neonatal neuroblastoma (NB).
Methods
A retrospective analysis was performed on 42 patients with NB between January 1994 and December 2011.
Results
MYCN amplification was detected in nine tumor samples. The ratio of unfavorable histology to favorable histology was 1:2 in NB patients. The 5-year overall survival (OS) of NB patients was 85.7 %. The 5-year OS in patients in the operation group was 83.3 %, chemotherapy group was 83.3 %, and the “wait-and-see” group was 100 % (P = 0.04). Overall, the prognosis was favorable, except in patients with elevated MYCN amplification or vanillylmandelic acid.
Conclusions
NB patients were more sensitive and vulnerable to chemotherapy and operation. The “wait-and-see” strategy should be highlighted in the treatment of NB.