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01-04-2015 | Original Article

RETRACTED ARTICLE: Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles de la Tourette syndrome patients

Authors: Weidong Ji, Ning Li, Kang Ju, Hong Zheng, Chuang Yang, Ping Xu, Silu Chen, Aiai Cao, Xue Chen, Lanting Guo

Published in: Neurological Sciences | Issue 4/2015

Abstract

Gilles de la Tourette syndrome (GTS) is a kind of neuropsychiatric disorder with childhood onset. The cognitive dysfunction caused by GTS could affect the growth and learning of children and adolescents. The mechanism of cognitive functions was associated with dopaminergic system, thus we access the associations between polymorphism of some dopaminergic system-related genes including Catechol-O-methyltransferase (COMT) met/val, Dopamine receptor D4 (DRD4) exon III 48 bp VNTR (variable number of tandem repeats), Interleukin 1 (IL-1) Ra 86 bp and IL-1β exon 5, and cognitive functions in GTS patients. Genotyping analysis was performed through polymerase chain reaction (PCR). Test for cognitive functions of GTS patients included modified wisconsin card sorting test (WCST), trail making test, visual reproduction test, stroop test and verbal fluency test. The patients with COMT met/met genotype showed less perseverative errors in modified WCST test compared with patients with COMT val/val genotype (P < 0.05). Meanwhile, patients without allele val had better delayed memory in visual reproduction test, less errors in the stroop test and less perseverative errors in modified WCST test compared with patients with allele val (P < 0.05). However, no significant difference was found in cognitive functions among patients with different genotypes or alleles of polymorphisms of DRD4 exon III 48 bp VNTR, IL-1 Ra 86 bp and IL-1β exon 5 (P > 0.05). Polymorphism of COMT met/val was correlated with cognitive functions in GTS patients. This study provided basis for the analysis of molecular genetic pathology of cognitive dysfunctions in GTS.

Robertson MM (2014) Movement disorders: tourette syndrome-beyond swearing and sex? Nat Rev Neurol 10:6–8. doi:10.1038/nrneurol.2013.248 CrossRefPubMed

Jankovic J, Kurlan R (2011) Tourette syndrome: evolving concepts. Mov Disord 26:1149–1156. doi:10.1002/mds.23618 CrossRefPubMed

Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P (2000) An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol 42:436–447CrossRefPubMed

Paus T (2005) Mapping brain maturation and cognitive development during adolescence. Trends Cogn Sci 9:60–68CrossRefPubMed

Lande MB, Kaczorowski JM, Auinger P, Schwartz GJ, Weitzman M (2003) Elevated blood pressure and decreased cognitive function among school-age children and adolescents in the United States. J Pediatr 143:720–724. doi:10.1067/S0022-3476(03)00412-8 CrossRefPubMed

Pandina GJ, Zhu Y, Cornblatt B (2009) Cognitive function with long-term risperidone in children and adolescents with disruptive behavior disorder. J Child Adolesc Psychopharmacol 19:749–756. doi:10.1089/cap.2008.0159 CrossRefPubMed

Reuter M, Peters K, Schroeter K, Koebke W, Lenardon D, Bloch B, Hennig J (2005) The influence of the dopaminergic system on cognitive functioning: a molecular genetic approach. Behav Brain Res 164:93–99. doi:10.1016/j.bbr.2005.06.002 CrossRefPubMed

Cropley VL, Fujita M, Innis RB, Nathan PJ (2006) Molecular imaging of the dopaminergic system and its association with human cognitive function. Biol Psychiatry 59:898–907. doi:10.1016/j.biopsych.2006.03.004 CrossRefPubMed

Henriquez BH, Henriquez HM, Carrasco ChX, Rothhammer AP, Llop RE, Aboitiz F, Rothhammer EF (2008) Combination of DRD4 and DAT1 genotypes is an important risk factor for attention deficit disorder with hyperactivity families living in Santiago, Chile. Rev Med Chil 136:719–724 (/S0034-98872008000600005)CrossRef

10.

Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland HH, Sanders ML, Gard JM, Stever C (1998) Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63:1767–1776. doi:10.1086/302132 PubMedCentralCrossRefPubMed

11.

DiMaio S, Grizenko N, Joober R (2003) Dopamine genes and attention-deficit hyperactivity disorder: a review. J Psychiatry Neurosci 28:27–38PubMedCentralPubMed

12.

Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE (2003) Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 23:2008–2013PubMed

13.

Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98:6917–6922. doi:10.1073/pnas.111134598 PubMedCentralCrossRefPubMed

14.

Tsuchimine S, Yasui-Furukori N, Kaneda A, Kaneko S (2013) Differential effects of the catechol-O-methyltransferase Val158Met genotype on the cognitive function of schizophrenia patients and healthy Japanese individuals. PLoS One 8:e76763. doi:10.1371/journal.pone.0076763 PubMedCentralCrossRefPubMed

15.

Hoogland J, de Bie RM, Williams-Gray CH, Muslimovic D, Schmand B, Post B (2010) Catechol-O-methyltransferase val158met and cognitive function in Parkinson’s disease. Mov Disord Off J Mov Disord Soc 25:2550–2554. doi:10.1002/mds.23319 CrossRef

16.

Galderisi S, Maj M, Kirkpatrick B, Piccardi P, Mucci A, Invernizzi G, Rossi A, Pini S, Vita A, Cassano P, Stratta P, Severino G, Del Zompo M (2005) Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive and motor impairment. Neuropsychobiology 52:83–89. doi:10.1159/000087096 CrossRefPubMed

17.

Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6:243–250CrossRefPubMed

18.

Segman RH, Meltzer A, Gross-Tsur V, Kosov A, Frisch A, Inbar E, Darvasi A, Levy S, Goltser T, Weizman A, Galili-Weisstub E (2002) Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder. Mol Psychiatry 7:72–74. doi:10.1038/sj/mp/4000919 CrossRefPubMed

19.

Perrier S, Coussediere C, Dubost JJ, Albuisson E, Sauvezie B (1998) IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjogren’s syndrome and rheumatoid arthritis. Clin Immunol Immunopathol 87:309–313CrossRefPubMed

20.

Hurme M, Santtila S (1998) IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1β genes. Eur J Immunol 28:2598–2602CrossRefPubMed

21.

Pociot F, MØLvig J, Wogensen L, Worsaae H, Nerup J (1992) A Taql polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro. Eur J Clin Invest 22:396–402. doi:10.1111/j.1365-2362.1992.tb01480.x CrossRefPubMed

22.

Guze SB (1995) Diagnostic and Statistical Manual of Mental Disorders, (DSM-IV). Am J Psychiatry 152:1228CrossRef

23.

Chen Y-F (2002) Chinese classification of mental disorders (CCMD-3): towards integration in international classification. Psychopathology 35:171–175CrossRefPubMed

24.

Chowbay B, Cumaraswamy S, Cheung YB, Zhou Q, Lee EJ (2003) Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenet Genomics 13:89–95CrossRef

25.

Jankovic J (2001) Tourette’s syndrome. N Engl J Med 345:1184–1192CrossRefPubMed

26.

Liu W, Hu T, Chen Y, Zhang X, Gu X, Guan M (2014) Development and validation of a tetra-primer amplification refractory mutation system-polymerase chain reaction combined with melting analysis-assay for clinical JAK2 V617F mutation detection. Mol Diagn Ther. doi:10.1007/s40291-014-0111-6

27.

Hoda F, Nicholl D, Bennett P, Arranz M, Aitchison KJ, Al-Chalabi A, Kunugi H, Vallada H, Leigh PN, Chaudhuri K (1996) No association between Parkinson’s disease and low-activity alleles of catechol <i> O </i> -Methyltransferase. Biochem Biophys Res Commun 228:780–784CrossRefPubMed

28.

Grimm C, Berger I, Tomovski C, Zeillinger R, Concin N, Leodolter S, Koelbl H, Tempfer CB, Hefler LA (2004) A polymorphism of the interleukin-1 receptor antagonist plays a prominent role within the interleukin-1 gene cluster in vulvar carcinogenesis. Gynecol Oncol 92:936–940CrossRefPubMed

29.

Nelson HE (1976) A modified card sorting test sensitive to frontal lobe defects. Cortex 12:313–324CrossRefPubMed

30.

Lu L, Bigler ED (2000) Performance on original and a Chinese version of Trail Making Test Part B: a normative bilingual sample. App Neuropsychol 7:243–246CrossRef

31.

Wechsler D (1987) Wechsler memory scale-revised. Psychological Corporation

32.

Zalonis I, Christidi F, Bonakis A, Kararizou E, Triantafyllou NI, Paraskevas G, Kapaki E, Vasilopoulos D (2009) The stroop effect in Greek healthy population: normative data for the Stroop Neuropsychological Screening Test. Arch Clin Neuropsychol 24:81–88. doi:10.1093/arclin/acp011 CrossRefPubMed

33.

Trenerry MR, Crosson B, DeBoe J, Leber W (1989) Stroop neuropsychological screening test manual. Psychological Assessment Resources Odessa, FL

34.

Sutherland RJ, Kolb B, Schoel WM, Whishaw IQ, Davies D (1982) Neuropsychological assessment of children and adults with Tourette syndrome: a comparison with learning disabilities and schizophrenia. Adv Neurol 35:311–322PubMed

35.

Barnett JH, Jones PB, Robbins TW, Muller U (2007) Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatr 12:502–509. doi:10.1038/sj.mp.4001973

36.

Joober R, Gauthier J, Lal S, Bloom D, Lalonde P, Rouleau G, Benkelfat C, Labelle A (2002) Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test. Arch Gen Psychiatry 59:662–663CrossRefPubMed

37.

Colzato LS, Waszak F, Nieuwenhuis S, Posthuma D, Hommel B (2010) The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: evidence for a role of dopamine in the control of task-switching. Neuropsychologia 48:2764–2768. doi:10.1016/j.neuropsychologia.2010.04.023 CrossRefPubMed

38.

Nolan KA, Bilder RM, Lachman HM, Volavka J (2004) Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility. Am J Psychiatry 161:359–361CrossRefPubMed

39.

Du L, Merali Z, Poulter MO, Palkovits M, Faludi G, Anisman H (2014) Catechol-O-methyltransferase Val158Met polymorphism and altered COMT gene expression in the prefrontal cortex of suicide brains. Prog Neuropsychopharmacol Biol Psychiatry 50:178–183. doi:10.1016/j.pnpbp.2013.12.016 CrossRefPubMed

40.

Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE (2003) Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci Off J Soc Neurosci 23:2008–2013

41.

Bowling KM, Huang Z, Xu D, Ferdousy F, Funderburk CD, Karnik N, Neckameyer W, O’Donnell JM (2008) Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis. J Biol Chem 283:31449–31459. doi:10.1074/jbc.M802552200 PubMedCentralCrossRefPubMed

42.

Maher BS, Marazita ML, Ferrell RE, Vanyukov MM (2002) Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis. Psychiatr Genet 12:207–215CrossRefPubMed

Title: RETRACTED ARTICLE: Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles de la Tourette syndrome patients
Authors: Weidong Ji
Ning Li
Kang Ju
Hong Zheng
Chuang Yang
Ping Xu
Silu Chen
Aiai Cao
Xue Chen
Lanting Guo
Publication date: 01-04-2015
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 4/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1992-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

RETRACTED ARTICLE: Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles de la Tourette syndrome patients

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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