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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2012

01-10-2012 | Letter

Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply

Authors: Dong Hyun Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi, William H Robinson

Published in: Arthritis Research & Therapy | Issue 5/2012

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Excerpt

We thank Oliviero and colleagues for their interest in our recent publication [1] and for reporting their very interesting related experiments [2]. Their results strongly support the concept that extravascular plasma proteins may act as damage-associated molecular patterns, and specifically as Toll-like receptor 4 agonists. In addition, we note that the NALP-3 inflammasome exhibits dependence on Toll-like receptor 4 or other mechanisms of priming of IL-1β transcription, thereby generating pro-IL-1β that can be converted to IL-1β by the activated inflammasome [3]. …
Literature
1.
Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, Lahey LJ, Lindstrom TM, Hwang I, Boyer KA, Andriacchi TP, Robinson WH: Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther. 2012, 14: R7-10.1186/ar3555.PubMedCentralCrossRefPubMed
2.
Oliviero F, Scanu A, Dayer J-M, Fiocco U, Sfriso P, Punzi L: Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4'. Arthritis Res Ther. 2012, 14: 405-PubMedCentralCrossRefPubMed
3.
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J: Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006, 440: 237-241. 10.1038/nature04516.CrossRefPubMed
4.
Smiley ST, King JA, Hancock WW: Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4. J Immunol. 2001, 167: 2887-2894.CrossRefPubMed
5.
Sokolove J, Zhao X, Chandra PE, Robinson WH: Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor. Arthritis Rheum. 2011, 63: 53-62.PubMedCentralCrossRefPubMed
Metadata
Title
Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply
Authors
Dong Hyun Sohn
Jeremy Sokolove
Orr Sharpe
Jennifer C Erhart
Piyanka E Chandra
Lauren J Lahey
Tamsin M Lindstrom
Inyong Hwang
Katherine A Boyer
Thomas P Andriacchi
William H Robinson
Publication date
01-10-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3892

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