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Respiratory Research
Published in: Respiratory Research 1/2016

Open Access 01-12-2016 | Review

Respiratory viral infections and host responses; insights from genomics

Authors: Niamh M. Troy, Anthony Bosco

Published in: Respiratory Research | Issue 1/2016

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Abstract

Respiratory viral infections are a leading cause of disease and mortality. The severity of these illnesses can vary markedly from mild or asymptomatic upper airway infections to severe wheezing, bronchiolitis or pneumonia. In this article, we review the viral sensing pathways and organizing principles that govern the innate immune response to infection. Then, we reconstruct the molecular networks that differentiate symptomatic from asymptomatic respiratory viral infections, and identify the underlying molecular drivers of these networks. Finally, we discuss unique aspects of the biology and pathogenesis of infections with respiratory syncytial virus, rhinovirus and influenza, drawing on insights from genomics.
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Metadata
Title
Respiratory viral infections and host responses; insights from genomics
Authors
Niamh M. Troy
Anthony Bosco
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2016
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-016-0474-9

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