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European Journal of Nutrition

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02-01-2024 | Respiratory Microbiota | Original Contribution

Effects of a prebiotic formulation on the composition of the faecal microbiota of people with functional constipation

Authors: Rene Erhardt, Elizabeth Steels, Joanna E. Harnett, Meng-Wong Taing, Kathryn J. Steadman

Published in: European Journal of Nutrition | Issue 3/2024

Abstract

Purpose

Prebiotics are defined as substances which selectively promote beneficial gut microbes leading to a health benefit for the host. Limited trials have been carried out investigating their effect on the microbiota composition of individuals afflicted by functional constipation with equivocal outcomes. In a 21-day randomised, controlled clinical trial involving 61 adults with functional constipation, a prebiotic formulation with partially hydrolysed guar gum and acacia gum as its main ingredients, significantly increased complete spontaneous bowel motions in the treatment group. This follow-up exploratory analysis investigated whether the prebiotic was associated with changes to the composition, richness, and diversity of the faecal microbiota.

Methods

Participants provided a faecal specimen at baseline and on day 21 of the intervention period. Whole genome metagenomic shotgun sequencing comprehensively assessed taxonomic and functional composition of the microbiota.

Results

Linear mixed effects regression models adjusted for potential confounders showed a significant reduction in species richness of 28.15 species (95% CI − 49.86, − 6.43) and Shannon diversity of 0.29 units (95% CI − 0.56, − 0.02) over the trial period in the prebiotic group. These changes were not observed in the control group, and functional composition was unchanged in both groups.

Conclusion

In adults with functional constipation, the intake of a prebiotic formulation was associated with a decline of species richness and Shannon diversity. Further research regarding the associations between prebiotics and the composition and function of the gut microbiota is warranted.

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Title: Effects of a prebiotic formulation on the composition of the faecal microbiota of people with functional constipation
Authors: Rene Erhardt
Elizabeth Steels
Joanna E. Harnett
Meng-Wong Taing
Kathryn J. Steadman
Publication date: 02-01-2024
Publisher: Springer Berlin Heidelberg
Keywords: Respiratory Microbiota
Constipation
Constipation
Published in: European Journal of Nutrition / Issue 3/2024
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-023-03292-9

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