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BMC Psychiatry
Published in: BMC Psychiatry 1/2024

Open Access 01-12-2024 | Respiratory Microbiota | Research

Alterations in the fecal microbiota of methamphetamine users with bad sleep quality during abstinence

Authors: Zijing Deng, Linzi Liu, Wen Liu, Ruina Liu, Tao Ma, Yide Xin, Yu Xie, Yifan Zhang, Yifang Zhou, Yanqing Tang

Published in: BMC Psychiatry | Issue 1/2024

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Abstract

Background

Methamphetamine (MA) abuse has resulted in a plethora of social issues. Sleep disturbance is a prominent issue about MA addiction, which serve as a risk factor for relapse, and the gut microbiota could play an important role in the pathophysiological mechanisms of sleep disturbances. Therefore, improving sleep quality can be beneficial for treating methamphetamine addiction, and interventions addressing the gut microbiota may represent a promising approach.

Method

We recruited 70 MA users to investigate the associations between sleep quality and fecal microbiota by the Pittsburgh Sleep Quality Index (PSQI), which was divided into MA-GS (PSQI score < 7, MA users with good sleep quality, n = 49) and MA-BS group (PSQI score ≥ 7, MA users with bad sleep quality, n = 21). In addition, we compared the gut microbiota between the MA-GS and healthy control (HC, n = 38) groups. 16S rRNA sequencing was applied to identify the gut bacteria.

Result

The study revealed that the relative abundances of the Thermoanaerobacterales at the order level differed between the MA-GS and MA-BS groups. Additionally, a positive correlation was found between the relative abundance of the genus Sutterella and daytime dysfunction. Furthermore, comparisons between MA users and HCs revealed differences in beta diversity and relative abundances of various bacterial taxa.

Conclusion

In conclusion, the study investigated alterations in the gut microbiota among MA users. Furthermore, we demonstrated that the genus Sutterella changes may be associated with daytime dysfunction, suggesting that the genus Sutterella may be a biomarker for bad sleep quality in MA users.
Appendix
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Metadata
Title
Alterations in the fecal microbiota of methamphetamine users with bad sleep quality during abstinence
Authors
Zijing Deng
Linzi Liu
Wen Liu
Ruina Liu
Tao Ma
Yide Xin
Yu Xie
Yifan Zhang
Yifang Zhou
Yanqing Tang
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2024
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-024-05773-5

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