Radionuclide myocardial perfusion imaging (MPI) is one of the most established and validated diagnostic modalities in the evaluation of patients with hemodynamically significant coronary artery disease (CAD).1–4 Growing public awareness and media attention toward the radiation exposure raised appropriate concerns related to the potential harmful effects of the radionuclide use. In 2010, American Society of Nuclear Cardiology (ASNC) issued a statement titled “Recommendations for reducing radiation exposure in myocardial perfusion imaging” addressing these issues.5 The use of appropriateness criteria for MPI, decreased radiotracer activity administration, utilization of newer solid state cameras, and novel image reconstruction are some of the ways to diminish ionizing radiation exposure in patients and healthcare professionals. This article will address image reconstruction possibilities for myocardial perfusion imaging (Figures 1, 2).