Published in:
Open Access
01-12-2010 | Poster presentation
Resistance after viral failure on atazanavir-containing therapy: multinational clinical cohort (BMS AI424-128 — 'IMPACT') final analysis
Authors:
A Zolopa, W Towner, A Lazzarin, G Fätkenheuer, D Butcher, J Uy
Published in:
Journal of the International AIDS Society
|
Special Issue 4/2010
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Excerpt
Real world data on the development of drug resistance after virologic failure (VF) on a protease inhibitor (PI)-based antiretroviral (ARV) regimen are limited. The I50L substitution in protease is the primary mutation associated with atazanavir drug resistance. The primary objective was to compare the prevalence of I50L from VF patients on an unboosted atazanavir (ATV)-based regimen vs. those on a ritonavir-boosted ATV (ATV/r)-based regimen regardless of prior treatment history. …