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01-01-2017 | CORRESPONDENCE

Reply to Greenland: A serious misinterpretation of a consistent inverse association of statin use with glioma across 3 case–control studies

Authors: Corinna Seliger, Christoph R. Meier, Claudia Becker, Susan S. Jick, Ulrich Bogdahn, Peter Hau, Michael F. Leitzmann

Published in: European Journal of Epidemiology | Issue 1/2017

Excerpt

We thank Dr. Greenland for raising an important issue concerning the interpretation of our data and we briefly respond to his points [1], as also presented in other recent articles [2, 3]. Before doing so, we would like to clarify that the title of his response is overstated because it leads the reader into believing that we interpreted the association between statin use and glioma as not being inverse across three studies. In contrast to the misleading wording of Dr. Greenland’s title, we interpreted the data of only one study (namely our own) as there being no association between statins and glioma [4], but consistently referred to previous studies [5, 6] as supporting an inverse relation between the two. …

Greenland S. A serious misinterpretation of a consistent inverse association of statin use with glioma across 3 case–control studies. Eur J Epidemiol (under production).

Greenland S, Senn SJ, Rothman KJ, Carlin JB, Poole C, Goodman SN, Altman DG. Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations. Eur J Epidemiol. 2016;31:337–50.CrossRefPubMedPubMedCentral

Rothman KJ. Disengaging from statistical significance. Eur J Epidemiol. 2016;31:443–4.CrossRefPubMed

Seliger C, Meier CR, Becker C, Jick SS, Bogdahn U, Hau P, Leitzmann MF. Statin use and risk of glioma: population-based case–control analysis. Eur J Epidemiol. 2016;31:947–52.CrossRefPubMed

Ferris JS, McCoy L, Neugut AI, Wrensch M, Lai R. HMG CoA reductase inhibitors, NSAIDs and risk of glioma. Int J Cancer. 2012;131:E1031–7.CrossRefPubMedPubMedCentral

Gaist D, Andersen L, Hallas J, Sorensen HT, Schroder HD, Friis S. Use of statins and risk of glioma: a nationwide case–control study in Denmark. Br J Cancer. 2013;108:715–20.CrossRefPubMedPubMedCentral

Title: Reply to Greenland: A serious misinterpretation of a consistent inverse association of statin use with glioma across 3 case–control studies
Authors: Corinna Seliger
Christoph R. Meier
Claudia Becker
Susan S. Jick
Ulrich Bogdahn
Peter Hau
Michael F. Leitzmann
Publication date: 01-01-2017
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 1/2017
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-016-0212-0

At a glance: The STEP trials

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Reply to Greenland: A serious misinterpretation of a consistent inverse association of statin use with glioma across 3 case–control studies

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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