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01-09-2016 | Letter to the Editor

Statin use and risk of glioma: population-based case–control analysis

Authors: Corinna Seliger, Christoph Rudolf Meier, Claudia Becker, Susan Sara Jick, Ulrich Bogdahn, Peter Hau, Michael Fred Leitzmann

Published in: European Journal of Epidemiology | Issue 9/2016

Abstract

Statins have been reported to decrease the incidence of cancer, but the risk of glioma among statin users has been investigated in only two prior observational studies, both of them suggesting a modest protective effect of statins. We conducted a matched case–control study using data from the UK-based Clinical Practice Research Datalink to analyse use of statins among 2469 cases with glioma and 24,690 controls. We performed conditional logistic regression analysis to calculate relative risks, estimated as odds ratios (ORs) with 95 % confidence intervals (CIs) adjusting for multiple confounding factors. As compared with non-use of statins, use of statins was not associated with risk of glioma (OR for ≥90 prescriptions=0.75; 95 % CI 0.48–1.17). Our findings do not support previous sparse evidence of a possible inverse association between statin use and glioma risk.

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Title: Statin use and risk of glioma: population-based case–control analysis
Authors: Corinna Seliger
Christoph Rudolf Meier
Claudia Becker
Susan Sara Jick
Ulrich Bogdahn
Peter Hau
Michael Fred Leitzmann
Publication date: 01-09-2016
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 9/2016
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-016-0145-7

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Statin use and risk of glioma: population-based case–control analysis

Abstract

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Abstract

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