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Diabetologia
Published in: Diabetologia 5/2007

01-05-2007 | Article

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

Authors: T. Hayashi, Y. Iwamoto, K. Kaku, H. Hirose, S. Maeda

Published in: Diabetologia | Issue 5/2007

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Abstract

Aims/hypothesis

The transcription factor 7-like 2 gene (TCF7L2) has been shown to be strongly associated with an increased risk of type 2 diabetes in white populations. To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TCF7L2 polymorphisms with type 2 diabetes in a Japanese population.

Subjects and methods

We analysed four SNPs (rs12255372, rs7903146, rs7901695 and rs11196205) and one tetranucleotide repeat polymorphism (DG10S478) in 1,630 Japanese subjects with type 2 diabetes and 1,064 control subjects.

Results

All investigated polymorphisms were significantly associated with type 2 diabetes, and rs12255372 showed the strongest association (T vs G, χ 2 = 9.20, p = 0.0024, odds ratio = 1.70, 95% CI = 1.20–2.41), although the frequency of the risk allele in our population was much lower than that in white populations. The microsatellite polymorphism showed an almost complete linkage disequilibrium to rs1255372 when the alleles with longer repeats (+8, +12) were considered as minor alleles and showed an association with type 2 diabetes (χ 2 = 5.34, p = 0.021, odds ratio = 1.50, 95% CI = 1.06–2.12).

Conclusions/interpretation

These results indicate that TCF7L2 might be a strong candidate for conferring susceptibility to type 2 diabetes across different ethnicities.
Appendix
Available only for authorised users
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Metadata
Title
Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
Authors
T. Hayashi
Y. Iwamoto
K. Kaku
H. Hirose
S. Maeda
Publication date
01-05-2007
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 5/2007
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-007-0618-z

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