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Trials
Published in: Trials 1/2015

Open Access 01-12-2015 | Study protocol

Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial

Authors: Iuri Santana Neville, Cintya Yukie Hayashi, Simone Alves El Hajj, Ana Luiza Costa Zaninotto, Juliana Perez Sabino, Leonardo Moura Sousa Jr, Marcia Mitie Nagumo, André Russowsky Brunoni, Barbara Dal Forno Silva Shieh, Robson Luis Oliveira Amorim, Manoel Jacobsen Teixeira, Wellingson Silva Paiva

Published in: Trials | Issue 1/2015

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Abstract

Background

Repetitive Transcranial Magnetic Stimulation (rTMS) has been proposed as a new tool in neurological rehabilitation of victims of traumatic brain injury (TBI). However, its usefulness to treat this condition has never been tested rigorously. The primary goal is to conduct a study protocol to determine whether rTMS used to cognitive rehabilitation of victims of TBI with diffuse axonal injury (DAI) is a safe instrument and if it enhances cognitive function recovery.

Methods

Double-blind randomized controlled trial of patients with diffuse axonal injury. Thirty-six patients will be randomized to either an active coil group or sham group in a 1:1 ratio. rTMS protocol: 10 sessions of high-frequency rTMS (10 Hz) over the left dorsolateral prefrontal cortex (DLPFC). Cortical Excitability measures will be obtained. Neuropsychological evaluations will be performed 1 week before, 1 week and 3 months after rTMS. There are 2 study hypotheses: (1) rTMS over the left DLPFC in patients with DAI will improve cognitive function and (2) whether rTMS is safe in TBI patients.

Discussion

This study evaluates the immediate and delayed effects of rTMS over the DLPFC on the cognitive domain of patients with DAI following TBI. rTMS has shown good results in treating major depression and may be promising for patients with TBI. As such, the results of this study can greatly modify the cognitive rehabilitation strategies.

Trial registration

This trial was registered in clinicaltrials.gov (NCT02167971) on 17 June 2014.
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Metadata
Title
Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial
Authors
Iuri Santana Neville
Cintya Yukie Hayashi
Simone Alves El Hajj
Ana Luiza Costa Zaninotto
Juliana Perez Sabino
Leonardo Moura Sousa Jr
Marcia Mitie Nagumo
André Russowsky Brunoni
Barbara Dal Forno Silva Shieh
Robson Luis Oliveira Amorim
Manoel Jacobsen Teixeira
Wellingson Silva Paiva
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Trials / Issue 1/2015
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-015-0944-2

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