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European Radiology
Published in: European Radiology 8/2018

01-08-2018 | Magnetic Resonance

Renal fat fraction and diffusion tensor imaging in patients with early-stage diabetic nephropathy

Authors: Yuan-Cheng Wang, Yinglian Feng, Chun-Qiang Lu, Shenghong Ju

Published in: European Radiology | Issue 8/2018

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Abstract

Objective

To investigate the renal fat fraction and water molecular diffusion features in patients with early-stage DN using Dixon imaging and diffusion tensor imaging (DTI).

Methods

Sixty-one type 2 diabetics (normoalbuminuria: n = 40; microalbuminuria: n = 21) and 34 non-diabetic volunteers were included. All participants received three-point Dixon imaging and DTI using a 3.0-T magnetic resonance imager. The fat fraction [FF] and DTI features [fractional anisotropy (FA), apparent diffusion coefficient (ADC), tract counts and length from DTI tractography] were collected. All image features were compared between cohorts using one-way ANOVA with Bonferroni post-hoc analysis.

Results

Renal FF in the microalbuminuric group was significantly higher than in the normoalbuminuric and control groups (5.6% ± 1.3%, 4.7% ± 1.1% and 4.3% ± 0.5%, respectively; p < 0.001). Medullary FA in the microalbuminuric group was the lowest (0.31 ± 0.06) in all cohorts. The tract counts and length in the renal medulla were significantly lower in the microalbuminuric group than in the other two groups.

Conclusions

Dixon imaging and DTI are able to detect renal lipid deposition and water molecule diffusion abnormalities in patients with early-stage DN. Both techniques have the potential to noninvasively evaluate early renal impairment in type 2 diabetes.

Key points

• Dixon imaging demonstrated renal fat deposition in early-stage DN;
• Renal fractional anisotropy decreased in patients with early-stage DN;
• Renal tractography demonstrated reduced track counts and length in early-stage DN.
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Metadata
Title
Renal fat fraction and diffusion tensor imaging in patients with early-stage diabetic nephropathy
Authors
Yuan-Cheng Wang
Yinglian Feng
Chun-Qiang Lu
Shenghong Ju
Publication date
01-08-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5298-6

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