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01-08-2015 | Magnetic Resonance

Renal blood flow using arterial spin labelling MRI and calculated filtration fraction in healthy adult kidney donors Pre-nephrectomy and post-nephrectomy

Authors: Marica Cutajar, Rachel Hilton, Jonathon Olsburgh, Stephen D Marks, David L Thomas, Tina Banks, Christopher A Clark, Isky Gordon

Published in: European Radiology | Issue 8/2015

Abstract

Objectives

Renal plasma flow (RPF) (derived from renal blood flow, RBF) and glomerular filtration rate (GFR) allow the determination of the filtration fraction (FF), which may have a role as a non-invasive renal biomarker. This is a hypothesis-generating pilot study assessing the effect of nephrectomy on renal function in healthy kidney donors.

Methods

Eight living kidney donors underwent arterial spin labelling (ASL) magnetic resonance imaging (MRI) and GFR measurement prior to and 1 year after nephrectomy. Chromium-51 labelled ethylenediamine tetraacetic acid (⁵¹Cr-EDTA) with multi-blood sampling was undertaken and GFR calculated. The RBF and GFR obtained were used to calculate FF.

Results

All donors showed an increase in single kidney GFR of 24 – 75 %, and all but two showed an increase in FF (−7 to +52 %) after nephrectomy. The increase in RBF, and hence RPF, post-nephrectomy was not as great as the increase in GFR in seven out of eight donors. As with any pilot study, the small number of donors and their relatively narrow age range are potential limiting factors.

Conclusions

The ability to measure RBF, and hence RPF, non-invasively, coupled with GFR measurement, allows calculation of FF, a biomarker that might provide a sensitive indicator of loss of renal reserve in potential donors.

Key Points

• Non-invasive MRI measured renal blood flow and calculated renal plasma flow.

• Effect of nephrectomy on blood flow and filtration in donors is presented.

• Calculated filtration fraction may be a useful new kidney biomarker.

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Title: Renal blood flow using arterial spin labelling MRI and calculated filtration fraction in healthy adult kidney donors Pre-nephrectomy and post-nephrectomy
Authors: Marica Cutajar
Rachel Hilton
Jonathon Olsburgh
Stephen D Marks
David L Thomas
Tina Banks
Christopher A Clark
Isky Gordon
Publication date: 01-08-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 8/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3594-6

At a glance: The STEP trials

Springer Medicine

Renal blood flow using arterial spin labelling MRI and calculated filtration fraction in healthy adult kidney donors Pre-nephrectomy and post-nephrectomy

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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