Skip to main content
Top
Published in: Aesthetic Plastic Surgery 3/2018

01-06-2018 | Original Article

Removal of Polyacrylamide Gel (Aquamid®) from the Lip as a Solution for Late-Onset Complications: Our 8-Year Experience

Authors: Sonja Kästner, Phillipp Gonser, Felix Paprottka, Kai O. Kaye

Published in: Aesthetic Plastic Surgery | Issue 3/2018

Login to get access

Abstract

Background

The polyacrylamide hydrogel Aquamid® has been used as a permanent filler to enhance facial soft tissue volume and correct wrinkles since 2001. Various long-term studies have proved the safety of the product. Nonetheless, if complications such as migration occur, they can be difficult to treat.

Methods

Eleven patients suffering from late-onset complications after taking Aquamid® injections in the lips underwent product removal and subsequent labial reconstruction between 2009 and 2017. The reconstruction was performed using a modified bikini reduction technique combined, in eight cases, with immediate autologous fat grafting.

Results

In all the patients, general fibrosis and a diffused distribution of the product within all three layers of the lips resulted in the need for labial reconstruction. Migration, as far as in the mucosa and perioral skin, accounted for macroscopically visible yellowish accumulations. In ten out of eleven cases, an individually modified bikini reduction technique, with or without any combination of autologous fat grafting, led to an esthetically satisfying result. One patient developed a severe upper lip necrosis.

Conclusion

Contradictory to several previous studies attesting to the lack of migration after Aquamid® application to the lips, capsule formation around the product is impaired, allowing for migration even years after the injection. Product aspiration is not possible in these cases, thus necessitating complex lip reconstruction. Bikini reduction and fat grafting are valuable tools for labial reconstruction. Product residuals within the mucosa have to be accepted. Special care has to be taken while treating smokers.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
Literature
1.
go back to reference McCollister D, Hake C, Sadek S, Rowe V (1965) Toxicological investigations of polyacrylamides. Toxicol Appl 7:639CrossRef McCollister D, Hake C, Sadek S, Rowe V (1965) Toxicological investigations of polyacrylamides. Toxicol Appl 7:639CrossRef
2.
go back to reference Smith E, Oehma F (1991) Acrylamide and polyacrylamide:a review of production, use, environmental fate and neurotoxicity. Rev Environ Health 9:215CrossRefPubMed Smith E, Oehma F (1991) Acrylamide and polyacrylamide:a review of production, use, environmental fate and neurotoxicity. Rev Environ Health 9:215CrossRefPubMed
3.
go back to reference Christensen L, Breiting V, Aasted A, Jørgensen A, Kebuladze I (2003) Long term effects of polyacrylamide hydrogel on human breast tissue. Plast Reconstr Surg 111:1883CrossRefPubMed Christensen L, Breiting V, Aasted A, Jørgensen A, Kebuladze I (2003) Long term effects of polyacrylamide hydrogel on human breast tissue. Plast Reconstr Surg 111:1883CrossRefPubMed
4.
go back to reference Caulfield M, Qiao G, Solomon D (2002) Some aspects of the properties and degradation of polyacrylamides. Chem Rev 102:3067–3084CrossRefPubMed Caulfield M, Qiao G, Solomon D (2002) Some aspects of the properties and degradation of polyacrylamides. Chem Rev 102:3067–3084CrossRefPubMed
6.
go back to reference Wolters M, Lampe H (2009) Prospective multicenter study for evaluation of safety, efficacy, and esthetic results of cross-linked polyacrylamide hydrogel in 81 patients. Dermatol Surg 35:338–343CrossRefPubMed Wolters M, Lampe H (2009) Prospective multicenter study for evaluation of safety, efficacy, and esthetic results of cross-linked polyacrylamide hydrogel in 81 patients. Dermatol Surg 35:338–343CrossRefPubMed
7.
go back to reference Pallua N, Wolter T (2010) A 10-year assessment of safety and aesthetic results after facial soft-tissue augmentation with polyacrylamide hydrogel (Aquamid): a prospective multicenter study of 251 patients. Plast Reconstr Surg 125:1797–1804CrossRefPubMed Pallua N, Wolter T (2010) A 10-year assessment of safety and aesthetic results after facial soft-tissue augmentation with polyacrylamide hydrogel (Aquamid): a prospective multicenter study of 251 patients. Plast Reconstr Surg 125:1797–1804CrossRefPubMed
8.
go back to reference Kalantar- Hormozi A, Mozafari N, Rasti M (2008) Adverse effects after use of polyacrylamide gel as a facial soft tissue filler. Aesthet Surg J 28:139–142CrossRefPubMed Kalantar- Hormozi A, Mozafari N, Rasti M (2008) Adverse effects after use of polyacrylamide gel as a facial soft tissue filler. Aesthet Surg J 28:139–142CrossRefPubMed
9.
go back to reference Nygart J, Nygart V, Borggren M, Tvede M (2014) Effect of prophylactic antibiotics on polyacrylamide gel saftey in facial augmentation. J Drugs Dermatol 13:571–573PubMed Nygart J, Nygart V, Borggren M, Tvede M (2014) Effect of prophylactic antibiotics on polyacrylamide gel saftey in facial augmentation. J Drugs Dermatol 13:571–573PubMed
10.
go back to reference Negredo E, Puig J, Ornelas A, Echeverría P, Bonjoch A, Estany C, Higueras C, Gonzalez-Mestre V, Clotet B (2009) Ten-year safety with polyacrylamide gel used to correct facial lipoatrophy in HIV-infected patients. AIDS Res Hum Retrovir 25:451–455CrossRefPubMed Negredo E, Puig J, Ornelas A, Echeverría P, Bonjoch A, Estany C, Higueras C, Gonzalez-Mestre V, Clotet B (2009) Ten-year safety with polyacrylamide gel used to correct facial lipoatrophy in HIV-infected patients. AIDS Res Hum Retrovir 25:451–455CrossRefPubMed
11.
go back to reference Von Buelow S, Pallua N (2005) Efficacy and safety of polyacrylamide hydrogel for facial soft tissue augmentation. Plast Reconstr Surg 116:1137–1146CrossRef Von Buelow S, Pallua N (2005) Efficacy and safety of polyacrylamide hydrogel for facial soft tissue augmentation. Plast Reconstr Surg 116:1137–1146CrossRef
12.
go back to reference Christensen L, Breitling V, Janssen M, Vuust J, Hogdall E (2005) Adverse reactions to injectable soft tissue permanent fillers. Aesthet Plast Surg 29:34–48CrossRef Christensen L, Breitling V, Janssen M, Vuust J, Hogdall E (2005) Adverse reactions to injectable soft tissue permanent fillers. Aesthet Plast Surg 29:34–48CrossRef
13.
go back to reference Wolter T, Pallua N (2010) Removal of the permanent filler polyacrylamide hydrogel (Aquamid) is possible and easy even after several years. Plast Reconstr Surg 126:138e–139eCrossRefPubMed Wolter T, Pallua N (2010) Removal of the permanent filler polyacrylamide hydrogel (Aquamid) is possible and easy even after several years. Plast Reconstr Surg 126:138e–139eCrossRefPubMed
14.
15.
go back to reference Yoskovitch A, Fanous N (2003) Correction of thin lips: a 17-year follow-up of the original technique. Plast Reconstr Surg 112:670–675CrossRefPubMed Yoskovitch A, Fanous N (2003) Correction of thin lips: a 17-year follow-up of the original technique. Plast Reconstr Surg 112:670–675CrossRefPubMed
16.
go back to reference Botti G, Botti C, Cella A (2002) A simple surgical remedy for iatrogenic excessively thick lips. Plast Reconstr Surg 110:1329–1334PubMed Botti G, Botti C, Cella A (2002) A simple surgical remedy for iatrogenic excessively thick lips. Plast Reconstr Surg 110:1329–1334PubMed
17.
go back to reference Bello G, Jackson I, Keskin M, Kelly C, Dajani K, Studinger R, Kim EM, Lincoln D, Silberberg B, Lee A (2007) The use of Polyacrylamide gel in soft-tissue augmentation: an experimental assessment. Plast Reconst Surg 119:1326–1336CrossRefPubMed Bello G, Jackson I, Keskin M, Kelly C, Dajani K, Studinger R, Kim EM, Lincoln D, Silberberg B, Lee A (2007) The use of Polyacrylamide gel in soft-tissue augmentation: an experimental assessment. Plast Reconst Surg 119:1326–1336CrossRefPubMed
18.
go back to reference Zarini E, Supino R, Pratesi G, Laccabue D, Tortoreto M, Scanziani E, Ghisleni G, Paltrinieri S, Tunesi G, Nava M (2004) Biocompatibility and tissue interactions of a new filler material for medical use. Plast Reconstr Surg 114:934–942CrossRefPubMed Zarini E, Supino R, Pratesi G, Laccabue D, Tortoreto M, Scanziani E, Ghisleni G, Paltrinieri S, Tunesi G, Nava M (2004) Biocompatibility and tissue interactions of a new filler material for medical use. Plast Reconstr Surg 114:934–942CrossRefPubMed
19.
go back to reference De Cassia Novaes W, Berg A (2003) Experiences with a new nonbiodegradable hydrogel (Aquamid): a pilot study. Aesthet Plast Surg 27:276–380 De Cassia Novaes W, Berg A (2003) Experiences with a new nonbiodegradable hydrogel (Aquamid): a pilot study. Aesthet Plast Surg 27:276–380
20.
go back to reference Cheng NX, Xu SL, Deng H, Ding XB, Zhang XM, Wu DH, Zhong H, Sun ZH (2006) Migration of implants: a problem with injectable polyacrylamide gel in aesthetic plastic surgery. Aesthet Plast Surg 30:215–225CrossRef Cheng NX, Xu SL, Deng H, Ding XB, Zhang XM, Wu DH, Zhong H, Sun ZH (2006) Migration of implants: a problem with injectable polyacrylamide gel in aesthetic plastic surgery. Aesthet Plast Surg 30:215–225CrossRef
21.
go back to reference Xu XG, Zhu ZX, Jin BY (2002) Dynamics study of polyacrylamide hydrogel in vivo. J Pract Aesthet Plast Surg 13:41–43 Xu XG, Zhu ZX, Jin BY (2002) Dynamics study of polyacrylamide hydrogel in vivo. J Pract Aesthet Plast Surg 13:41–43
22.
go back to reference Christensen L (2007) Normal and pathologic tissue reactions to soft tissue gel fillers. Dermatol Surg 33:168–175 Christensen L (2007) Normal and pathologic tissue reactions to soft tissue gel fillers. Dermatol Surg 33:168–175
23.
go back to reference Christensen L, Breiting V, Bjarnsholt T, Eickhardt S, Høgdall E, Janssen M, Pallua N, Zaat SA (2013) Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery. Clin Infect Dis 56:1438–1444CrossRefPubMed Christensen L, Breiting V, Bjarnsholt T, Eickhardt S, Høgdall E, Janssen M, Pallua N, Zaat SA (2013) Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery. Clin Infect Dis 56:1438–1444CrossRefPubMed
24.
go back to reference El-Shafey S (2008) Complications from repeated injection or puncture of old polyacrylamide gel implant sites: case reports. Aesthet Plast Surg 32:162–165CrossRef El-Shafey S (2008) Complications from repeated injection or puncture of old polyacrylamide gel implant sites: case reports. Aesthet Plast Surg 32:162–165CrossRef
Metadata
Title
Removal of Polyacrylamide Gel (Aquamid®) from the Lip as a Solution for Late-Onset Complications: Our 8-Year Experience
Authors
Sonja Kästner
Phillipp Gonser
Felix Paprottka
Kai O. Kaye
Publication date
01-06-2018
Publisher
Springer US
Published in
Aesthetic Plastic Surgery / Issue 3/2018
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-018-1114-1

Other articles of this Issue 3/2018

Aesthetic Plastic Surgery 3/2018 Go to the issue