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BMC Anesthesiology

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Open Access 01-12-2020 | Remifentanil | Research article

Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial

Authors: Li Jia, Meng Xie, Jing Zhang, Jingyu Guo, Tong Tong, Yuying Xing

Published in: BMC Anesthesiology | Issue 1/2020

Abstract

Background

Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination. This study was to evaluate the effects of different doses of the dexmedetomidine-remifentanil combination in colonoscopy.

Methods

This was a prospective trial carried out at the Fourth Hospital of Hebei Medical University between 02/2018 and 10/2018. The patients were randomized: group I (dexmedetomidine 0.2 μg·kg^− 1), group II (dexmedetomidine 0.3 μg·kg^− 1), and group III (dexmedetomidine 0.4 μg·kg^− 1), all combined with remifentanil. The primary outcomes were the patient’s body movements during the procedure and adverse events.

Results

Compared with at admission (T₀), the SBP, HR, and RR at immediately after giving DEX (T₁), at the beginning of the examination (T₂), 5 min after the beginning of the examination (T₃), 10 min after the beginning of the examination (T₄), and at the end of the examination (T₅) in the three groups were all reduced (all P < 0.05), but all were within the clinically normal range. SpO₂ remained > 98% in all patients during the examination. Compared with T₀, the BIS values of the three groups were decreased at T₁ and T₂ (all P < 0.05). There were no significant differences in BIS among the three groups (all P > 0.05). The minimum BIS value in group III was lower than in groups I and II (P < 0.05). The degree of satisfaction with the anesthesia effect was higher in groups II and III that in group I (P < 0.05). No hypotension occurred, seven patients had bradycardia, and four patients had nausea/vomiting.

Conclusions

Dexmedetomidine 0.3 μg·kg^− 1 combined with remifentanil was effective for colonoscopy and had few adverse reactions.

Chinese Clinical Trial Registry: ChiCTR2000029105, Registered 13 January 2020 - Retrospectively registered.

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Title: Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial
Authors: Li Jia
Meng Xie
Jing Zhang
Jingyu Guo
Tong Tong
Yuying Xing
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Remifentanil
Colonoscopy
Published in: BMC Anesthesiology / Issue 1/2020
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/s12871-020-01141-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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