Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
AIDS and Behavior
Published in: AIDS and Behavior 5/2015

01-05-2015 | Original Paper

Relative Risk for HIV Infection Among Men Who Have Sex with Men Engaging in Different Roles in Anal Sex: A Systematic Review and Meta-analysis on Global Data

Authors: Xiaojun Meng, Huachun Zou, Song Fan, Benfeng Zheng, Lin Zhang, Xin Dai, Minli Deng, Xuan Zhang, Bing Lu

Published in: AIDS and Behavior | Issue 5/2015

Login to get access

Abstract

We systematically reviewed and meta-analyzed global data on the relative risk for HIV infection among men who have sex with men (MSM) engaging in different roles in anal sex. MSM engaging in receptive anal sex only (MRAI) and MSM engaging in both insertive and receptive anal sex (MIRAI) were 6.9 (95 % CI 5.5–8.6) and 4.3 (95 % CI 3.6–5.3) times more likely to have prevalent HIV compared to MSM engaging in insertive anal sex only (MIAI) in 1981–1985. These figures were 1.8 (95 % CI 1.6–2.0) and 2.2 (95 % CI 2.0–2.4) in 1986–2010. Overall, MRAI and MIRAI were 6.2 (95 % CI 3.3–11.8) and 6.6 (95 % CI 3.8–11.7) times more likely to develop incident HIV infection compared to MIAI. MRAI are at higher risk for HIV infection compared to MIAI. HIV prevalence among men engaging in all roles in anal sex is high enough that all MSM should be aware of potential risk.
Appendix
Available only for authorised users
Literature
1.
Prejean J, Song R, Hernandez A, Ziebell R, Green T, Walker F, et al. Estimated HIV incidence in the United States, 2006–2009. PLoS One. 2011;6:e17502.CrossRefPubMedCentralPubMed
2.
Price M, Rida W, Mwangome M. Identifying at-risk populations in Kenya and South Africa: HIV incidence in cohorts of men who report sex with men, sex workers, and youth. J Acquir Immune Defic Syndr. 2012;59:185–93.CrossRefPubMed
3.
4.
Wirtz AL. The global HIV epidemics among men who have sex with men. Washington: World Bank Publications; 2011.
5.
Johnson WD, Diaz RM, Flanders WD, Goodman M, Hill AN, Holtgrave D, et al. Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Cochrane Database Syst Rev. 2008;3:CD001230.PubMed
6.
Golden MR, Stekler J, Hughes JP, Wood RW. HIV serosorting in men who have sex with men: is it safe? J Acquir Immune Defic Syndr. 2008;49:212–8.CrossRefPubMed
7.
Rositch AF, Gravitt PE, Smith JS. Growing evidence that HPV infection is associated with an increase in HIV acquisition: exploring the issue of HPV vaccination. Sex Transm Infect. 2013;89:357.CrossRefPubMed
8.
Bernstein KT, Marcus JL, Nieri G, Philip SS, Klausner JD. Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion. J Acquir Immune Defic Syndr. 2010;53:537–43.CrossRefPubMed
9.
Ruan Y, Li D, Li X, Qian HZ, Shi W, Zhang X, et al. Relationship between syphilis and HIV infections among men who have sex with men in Beijing, China. Sex Transm Dis. 2007;34:592–7.PubMed
10.
Guy RJ, Spelman T, Stoove M, El-Hayek C, Goller J, Fairley CK, et al. Risk factors for HIV seroconversion in men who have sex with men in Victoria, Australia: results from a sentinel surveillance system. Sex Health. 2011;8:319–29.CrossRefPubMed
11.
12.
Trichopoulos D, Sparos L, Petridou E. Homosexual role separation and spread of AIDS. Lancet. 1988;2:965–6.CrossRefPubMed
13.
Zou H, Wu Z, Yu J, Li M, Ablimit M, Li F, et al. Sexual risk behaviors and HIV infection among men who have sex with men who use the internet in Beijing and Urumqi, China. J Acquir Immune Defic Syndr. 2010;53(Suppl 1):S81–7.CrossRefPubMedCentralPubMed
14.
Wegesin D, Meyer-Bahlburg H. Top/bottom selflabel, anal sex practices, HIV risk and gender role identity in gay men in NewYork City. J Psychol Human Sex. 2000;12:43–62.CrossRef
15.
Varghese B, Maher J, Peterman T, Branson B, Steketee R. Reducing the risk of sexual HIV transmission: quantifying the per-act risk for HIV on the basis of choice of partner, sex act, and condom use. Sex Transm Dis. 2002;29:38–43.CrossRefPubMed
16.
Kelly JA, Amirkhanian YA, McAuliffe TL, Granskaya JV, Borodkina OI, Dyatlov RV, et al. HIV risk characteristics and prevention needs in a community sample of bisexual men in St. Petersburg, Russia. AIDS Care. 2002;14:63–76.CrossRefPubMed
17.
Craib KJ, Weber AC, Cornelisse PG, Martindale SL, Miller ML, Schechter MT, et al. Comparison of sexual behaviors, unprotected sex, and substance use between two independent cohorts of gay and bisexual men. AIDS. 2000;14:303–11.CrossRefPubMed
18.
Zou H, Prestage G, Fairley CK, Grulich AE, Garland SM, Hocking JS, et al. Sexual behaviors and risk for sexually transmitted infections among teenage men who have sex with men. J Adolesc Health. 2014;55:247–53.CrossRefPubMed
19.
Agronick G, O’Donnell L, Stueve A, Doval AS, Duran R, Vargo S. Sexual behaviors and risks among bisexually- and gay-identified young Latino men. AIDS Behav. 2004;8:185–97.CrossRefPubMed
20.
Jin F, Jansson J, Law M, Prestage GP. Per-contact probability of HIV transmission in homosexual men in Sydney in the era of HAART. AIDS. 2010;24:907–13.CrossRefPubMedCentralPubMed
21.
David M, Alessandro L, Jennifer T, Douglas G, Group TP. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:1–6.
22.
Jameson DR, Celum CL, Manhart L, Menza TW, Golden MR. The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with men. Sex Transm Dis. 2010;37:147–52.CrossRefPubMed
23.
Chmiel JS, Detels R, Kaslow RA, Van Raden M, Kingsley LA, Brookmeyer R. Factors associated with prevalent human immunodeficiency virus (HIV) infection in the Multicenter AIDS Cohort Study. Am J Epidemiol. 1987;126:568–77.PubMed
24.
Izazola-Licea JA, Valdespino-Gomez JL, Gortmaker SL, Townsend J, Becker J, Palacios-Martinez M, et al. HIV-1 seropositivity and behavioral and sociological risks among homosexual and bisexual men in six Mexican cities. J Acquir Immune Defic Syndr. 1991;4:614–22.PubMed
25.
Chariyalertsak S, Kosachunhanan N, Saokhieo P, Songsupa R, Wongthanee A, Chariyalertsak C, et al. HIV incidence, risk factors, and motivation for biomedical intervention among gay, bisexual men, and transgender persons in Northern Thailand. PLoS One. 2011;6:e24295.CrossRefPubMedCentralPubMed
26.
Hladik W, Barker J, Ssenkusu JM, Opio A, Tappero JW, Hakim A, et al. HIV infection among men who have sex with men in Kampala, Uganda: a respondent driven sampling survey. PLoS One. 2012;7:e38143.CrossRefPubMedCentralPubMed
27.
Coplan PM, Gortmaker S, Hernandez-Avila M, Spiegelman D, Uribe-Zuniga P, Mueller NE. Human immunodeficiency virus infection in Mexico City. Rectal bleeding and anal warts as risk factors among men reporting sex with men. Am J Epidemiol. 1996;144:817–27.CrossRefPubMed
28.
Chen YJ, Lin YT, Chen M, Huang SW, Lai SF, Wong WW, et al. Risk factors for HIV-1 seroconversion among Taiwanese men visiting gay saunas who have sex with men. BMC Infect Dis. 2011;11:334.CrossRefPubMedCentralPubMed
29.
Goodreau SM, Peinado J, Goicochea P, Vergara J, Ojeda N, Casapia M, et al. Role versatility among men who have sex with men in urban Peru. J Sex Res. 2007;44:233–9.CrossRefPubMed
30.
Hernandez M, Uribe P, Gortmaker S, Avila C, De Caso LE, Mueller N, et al. Sexual behavior and status for human immunodeficiency virus type 1 among homosexual and bisexual males in Mexico City. Am J Epidemiol. 1992;135:883–94.PubMed
31.
Van Griensven F, Thanprasertsuk S, Jommaroeng R, Mansergh G, Naorat S, Jenkins RA, et al. Evidence of a previously undocumented epidemic of HIV infection among men who have sex with men in Bangkok, Thailand. AIDS. 2005;19:521–6.CrossRefPubMed
32.
Sanders EJ, Graham SM, Okuku HS, Van Der Elst EM, Muhaari A, Davies A, et al. HIV-1 infection in high risk men who have sex with men in Mombasa, Kenya. AIDS. 2007;21:2513–20.CrossRefPubMed
33.
Wei C, Raymond HF. Preference for and maintenance of anal sex roles among men who have sex with men: sociodemographic and behavioral correlates. Arch Sex Behav. 2011;40:829–34.CrossRefPubMed
34.
McDaid LM, Hart GJ. Serosorting and strategic positioning during unprotected anal intercourse: are risk reduction strategies being employed by gay and bisexual men in Scotland? Sex Transm Dis. 2012;39:735–8.CrossRefPubMed
35.
Li A, Varangrat A, Wimonsate W, Chemnasiri T, Sinthuwattanawibool C, Phanuphak P, et al. Sexual behavior and risk factors for HIV infection among homosexual and bisexual men in Thailand. AIDS Behav. 2009;13:318–27.CrossRefPubMed
36.
Winkelstein W Jr, Lyman DM, Padian N. Sexual practices and risk of infection by the human immunodeficiency virus. The San Francisco men’s health study. J Am Med Assoc. 1987;257:321–5.CrossRef
37.
Stein D, Silvera R, Hagerty R, Marmor M. Viewing pornography depicting unprotected anal intercourse: are there implications for HIV prevention among men who have sex with men? Arch Sex Behav. 2012;41:411–9.CrossRefPubMedCentralPubMed
38.
Zhou C, Raymond HF, Ding X, Lu R, Xu J, Wu G, et al. Anal sex role, circumcision status, and HIV infection among men who have sex with men in Chongqing, China. Arch Sex Behav. 2012;1–9.
39.
Zhong F, Lin P, Xu H, Wang Y, Wang M, He Q, et al. Possible increase in HIV and syphilis prevalence among men who have sex with men in Guangzhou, China: results from a respondent-driven sampling survey. AIDS Behav. 2011;15:1058–66.CrossRefPubMed
40.
Detels R, English P, Visscher BR, Jacobson L, Kingsley LA, Chmiel JS, et al. Seroconversion, sexual activity, and condom use among 2915 HIV seronegative men followed for up to 2 years. J Acquir Immune Defic Syndr. 1989;2:77–83.PubMed
41.
Scott HM, Vittinghoff E, Irvin R, Sachdev D, Liu A, Gurwith M, et al. Age, race/ethnicity, and behavioral risk factors associated with per contact risk of HIV infection among men who have sex with men in the United States. J Acquir Immune Defic Syndr. 2014;65:115–21.CrossRefPubMedCentralPubMed
42.
Vittinghoff E, Douglas J, Judson F, McKirnan D, MacQueen K, Buchbinder SP. Per-contact risk of human immunodeficiency virus transmission between male sexual partners. Am J Epidemiol. 1999;150:306–11.CrossRefPubMed
43.
Patel P, Borkowf CB, Brooks JT, Lasry A, Lansky A, Mermin J. Estimating per-act HIV transmission risk: a systematic review. AIDS. 2014;28:1509–19.CrossRefPubMed
44.
UNAIDS. Voluntary counselling and testing (VCT). UNAIDS Best Practice Collection 2000, Technical Update: 1–12.
45.
46.
De Rosa CJ, Marks G. Preventive counseling of HIV-positive men and self-disclosure of serostatus to sex partners: new opportunities for prevention. Health Psychol. 1998;17:224–31.CrossRefPubMed
47.
Crepaz N, Marks G. Serostatus disclosure, sexual communication and safer sex in HIV-positive men. AIDS Care. 2003;15:379–87.CrossRefPubMed
48.
Tindall B, Swanson C, Donovan B, Cooper DA. Sexual practices and condom usage in a cohort of homosexual men in relation to human immunodeficiency virus status. Med J Aust. 1989;151:318–22.PubMed
49.
Malunguza N, Mushayabasa S, Chiyaka C, Mukandavire Z. Modelling the effects of condom use and antiretroviral therapy in controlling HIV/AIDS among heterosexuals, homosexuals and bisexuals. Comput Math Methods Med. 2010;11:201–22.CrossRefPubMed
50.
Pinkerton SD, Abramson PR. Effectiveness of condoms in preventing HIV transmission. Soc Sci Med. 1997;44:1303–12.CrossRefPubMed
51.
Izazola-Licea JA, Avila-Figueroa RC, Gortmaker SL, del Rio-Chiriboga C. The homosexual transmission of HIV/AIDS in Mexico. Salud Publica Mex. 1995;37:602–14.PubMed
52.
Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493–505.CrossRefPubMedCentralPubMed
53.
Gulick RM, Mellors JW, Havlir D, Eron JJ, Gonzalez C, McMahon D, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med. 1997;337:734–9.CrossRefPubMed
54.
Maughan-Brown B. Variation in concurrent sexual partnerships and sexually transmitted diseases among African men in Cape Town, South Africa. Sex Transm Dis. 2012;39:537–42.CrossRefPubMed
55.
Grov C, Rendina HJ, Ventuneac A, Parsons JT. HIV risk in group sexual encounters: an event-level analysis from a national online survey of MSM in the US. J Sex Med. 2013;10:2285–94.CrossRefPubMedCentralPubMed
56.
Sander PM, Cole SR, Stall RD, Jacobson LP. Joint effects of alcohol consumption and high-risk sexual behavior on HIV eroconversion among men who have sex with men. AIDS. 2013;27:815–23.CrossRefPubMedCentralPubMed
57.
She M, Zhang H, Wang J, Xu J, Zhang Z, Fan Y, et al. Associated factors for HIV and syphilis infection among men who have sex with men only and men who have sex with both men and women in cities of China. Int J STD AIDS. 2013;24:293–300.CrossRefPubMed
58.
Malta M, Magnanini MM, Mello MB, Pascom ARP. HIV prevalence among female sex workers, drug users and men who have sex with men in Brazil: a systematic review and meta-analysis. BMC Public Health. 2010;10:317.CrossRefPubMedCentralPubMed
59.
Meng X, Zou H, Jack B, Xu Y. Trends in HIV prevalence among men who have sex with men in China 2003–2009: a systematic review and meta-analysis. Sex Health. 2013;10:211–9.PubMed
60.
Gough E, Kempf MC, Graham L, Manzanero M. HIV and Hepatitis B and C incidence rates in US correctional populations and high risk groups: a systematic review and meta-analysis. BMC Public Health. 2010;10:777.CrossRefPubMedCentralPubMed
Metadata
Title
Relative Risk for HIV Infection Among Men Who Have Sex with Men Engaging in Different Roles in Anal Sex: A Systematic Review and Meta-analysis on Global Data
Authors
Xiaojun Meng
Huachun Zou
Song Fan
Benfeng Zheng
Lin Zhang
Xin Dai
Minli Deng
Xuan Zhang
Bing Lu
Publication date
01-05-2015
Publisher
Springer US
Published in
AIDS and Behavior / Issue 5/2015
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-014-0921-x

Other articles of this Issue 5/2015

AIDS and Behavior 5/2015 Go to the issue

Original Paper

Factors Associated with Adherence and Concordance Between Measurement Strategies in an HIV Daily Oral Tenofovir/Emtricitibine as Pre-exposure Prophylaxis (Prep) Clinical Trial, Botswana, 2007–2010

Original Paper

Profiles of Risk Among HIV-Infected Youth in Clinic Settings

Original Paper

Prescription Drug Misuse and Sexual Risk Behaviors Among Young Men Who have Sex with Men (YMSM) in Philadelphia

Original Paper

Male Partner Influence on Women’s HIV Prevention Trial Participation and Use of Pre-exposure Prophylaxis: the Importance of “Understanding”

Original Paper

Understanding Adherence to Daily and Intermittent Regimens of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in Kenya

Original Paper

Accuracy of Self-Report and Pill-Count Measures of Adherence in the FEM-PrEP Clinical Trial: Implications for Future HIV-Prevention Trials
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits