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Journal of Cardiovascular Magnetic Resonance

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Open Access 01-12-2014 | Research

Relationship between mechanical dyssynchrony and intra-operative electrical delay times in patients undergoing cardiac resynchronization therapy

Authors: Jonathan D Suever, Gregory R Hartlage, R Patrick Magrath III, Shahriar Iravanian, Michael S Lloyd, John N Oshinski

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2014

Abstract

Background

It is important to understand the relationship between electrical and mechanical ventricular activation in CRT patients. By measuring local electrical activation at multiple locations within the coronary veins and myocardial contraction at the same locations in the left ventricle, we determined the relationship between electrical and mechanical activation at potential left ventricular pacing locations.

Methods

In this study, mechanical contraction times were computed using high temporal resolution cine cardiovascular magnetic resonance (CMR) data, while electrical activation times were derived from intra-procedural local electrograms.

Results

In our cohort, there was a strong correlation between electrical and mechanical delay times within each patient (R² = 0.78 ± 0.23). Additionally, the latest electrically activated location corresponded with the latest mechanically contracting location in 91% of patients.

Conclusions

This study provides initial evidence that our method of obtaining non-invasive mechanical activation patterns accurately reflects the underlying electromechanical substrate of intraventricular dyssynchrony.

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Title: Relationship between mechanical dyssynchrony and intra-operative electrical delay times in patients undergoing cardiac resynchronization therapy
Authors: Jonathan D Suever
Gregory R Hartlage
R Patrick Magrath III
Shahriar Iravanian
Michael S Lloyd
John N Oshinski
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue 1/2014
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/1532-429X-16-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between mechanical dyssynchrony and intra-operative electrical delay times in patients undergoing cardiac resynchronization therapy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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