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European Radiology
Published in: European Radiology 12/2016

01-12-2016 | Paediatric

Region of interest-based versus whole-lung segmentation-based approach for MR lung perfusion quantification in 2-year-old children after congenital diaphragmatic hernia repair

Authors: M. Weis, V. Sommer, F. G. Zöllner, C. Hagelstein, K. Zahn, T. Schaible, S. O. Schoenberg, K. W. Neff

Published in: European Radiology | Issue 12/2016

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Abstract

Objective

With a region of interest (ROI)-based approach 2-year-old children after congenital diaphragmatic hernia (CDH) show reduced MR lung perfusion values on the ipsilateral side compared to the contralateral. This study evaluates whether results can be reproduced by segmentation of whole-lung and whether there are differences between the ROI-based and whole-lung measurements.

Methods

Using dynamic contrast-enhanced (DCE) MRI, pulmonary blood flow (PBF), pulmonary blood volume (PBV) and mean transit time (MTT) were quantified in 30 children after CDH repair. Quantification results of an ROI-based (six cylindrical ROIs generated of five adjacent slices per lung-side) and a whole-lung segmentation approach were compared.

Results

In both approaches PBF and PBV were significantly reduced on the ipsilateral side (p always <0.0001). In ipsilateral lungs, PBF of the ROI-based and the whole-lung segmentation-based approach was equal (p=0.50). In contralateral lungs, the ROI-based approach significantly overestimated PBF in comparison to the whole-lung segmentation approach by approximately 9.5 % (p=0.0013).

Conclusions

MR lung perfusion in 2-year-old children after CDH is significantly reduced ipsilaterally. In the contralateral lung, the ROI-based approach significantly overestimates perfusion, which can be explained by exclusion of the most ventral parts of the lung. Therefore whole-lung segmentation should be preferred.

Key Points

• Ipsilaterally, absolute lung perfusion after CDH is reduced in whole-lung analysis.
• Ipsilaterally, the ROI- and whole-lung-based approaches generate identical results.
• Contralaterally, the ROI-based approach significantly overestimates perfusion results.
• Whole lung should be analysed in MR lung perfusion imaging.
• MR lung perfusion measurement is a radiation-free parameter of lung function.
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Metadata
Title
Region of interest-based versus whole-lung segmentation-based approach for MR lung perfusion quantification in 2-year-old children after congenital diaphragmatic hernia repair
Authors
M. Weis
V. Sommer
F. G. Zöllner
C. Hagelstein
K. Zahn
T. Schaible
S. O. Schoenberg
K. W. Neff
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 12/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4330-6

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