Published in:
01-04-2010 | Research Letter
Regeneration of insulin production by autologous bone marrow blood autotransplantation in patients with type 1 diabetes
Authors:
E. Esmatjes, X. Montaña, M. I. Real, J. Blanco, I. Conget, R. Casamitjana, M. Rovira, R. Gomis, P. Marin
Published in:
Diabetologia
|
Issue 4/2010
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Excerpt
To the Editor: Among the possible cellular therapies to replace insulin secretion in diabetes, bone marrow-derived stem cells have aroused interest because of their plasticity and ease of procurement. Indeed, some experimental reports suggest that the bone marrow harbours cells capable of differentiation into beta cells [
1‐
3], the transplantation of which can correct hyperglycaemia [
1,
4]. However, these findings have not been corroborated in other studies [
5]. Nonetheless, the experimental data are not conclusive and point to three potential roles of bone marrow cells in the treatment of diabetes, namely as a source of stem cells for beta cells, as a facilitator of beta cell regeneration and as an immune modulator. …
