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International Ophthalmology

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01-12-2024 | Refractive Errors | Original Paper

Longitudinal changes of refractive error in preschool children with congenital ectopia lentis

Authors: Zhangkai Lian, Yin Hu, Zhenzhen Liu, Charlotte Aimee Young, Siyuan Liu, Danying Zheng, Guangming Jin

Published in: International Ophthalmology | Issue 1/2024

Abstract

Background

Congenital ectopia lentis (CEL) is a hereditary eye disease which severely impacts preschool children’s visual function and development. This study aimed to evaluate the longitudinal changes in spherical equivalent (SE) refractive error in preschool children with CEL.

Methods

A retrospective cohort study was conducted at Zhongshan Ophthalmic Center, Guangzhou, China. Medical records of CEL patients under 6-year-old who were diagnosed with Marfan syndrome at the initial visit from January 2014 to March 2022 were collected and were divided into surgery and non-surgery groups. Mean change rate of SE in the two groups was evaluated, and the potential associated factors of SE change rate were investigated by mixed-effect regression model.

Results

A total of 94 preschool patients from 14 provinces of China were included. Among the 42 children of the surgery group, the mean age with standard deviation (SD) was 5.02 ± 0.81 years and patients experienced a myopic shift of –0.05 ± 0.09 D/month in average. The mean age with SD of the 52 children of the non-surgery group was 4.34 ± 1.02 years, and the mean myopic shift was –0.09 ± 0.14 D/month. The mixed-effect regression model identified that higher degree of myopia at baseline was associated with slower myopic shift both in surgery (β = 0.901, 95% CI: 0.822 ~ 0.980, P < 0.001) and in non-surgery group (β = 1.006, 95% CI: 0.977 ~ 1.034, P < 0.001) in CEL patients. Surgical treatment (β = 2.635, 95% CI: 1.376 ~ 3.894, P < 0.001) was associated with slower myopic shift in all participants CEL patients.

Conclusions

Myopic progression was slower in the surgery group than in the non-surgery group of CEL. Preschool CEL patients who met the surgical indication are suggested being performed with timely surgery to slow down the myopic progression.

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Title: Longitudinal changes of refractive error in preschool children with congenital ectopia lentis
Authors: Zhangkai Lian
Yin Hu
Zhenzhen Liu
Charlotte Aimee Young
Siyuan Liu
Danying Zheng
Guangming Jin
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keywords: Refractive Errors
Marfan Syndrome
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-02953-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Longitudinal changes of refractive error in preschool children with congenital ectopia lentis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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