Skip to main content
Top
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 12/2017

01-12-2017 | Refractive Surgery

Refractive, corneal and ocular residual astigmatism: distribution in a German population and age-dependency - the Gutenberg health study

Authors: Alexander Karl-Georg Schuster, Norbert Pfeiffer, Andreas Schulz, René Hoehn, Katharina A. Ponto, Philipp S. Wild, Maria Blettner, Manfred E. Beutel, Karl J. Lackner, Thomas Münzel, Alireza Mirshahi

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2017

Login to get access

Abstract

Purpose

Worldwide, the most frequent cause of visual impairment is uncorrected refractive error. This analysis focused on the distribution and associations of refractive, corneal and ocular residual astigmatism.

Methods

As part of the Gutenberg Health study, a population-based cross-sectional study was conducted in the general population of Germany. A comprehensive ophthalmological examination including refraction, tonometry, and Scheimpflug imaging of the anterior cornea (Pachycam) was performed. In addition to the magnitude and type (with-the-rule, against-the-rule, oblique) of the refractive or corneal astigmatism, we calculated the vector components (J0, J45) of both astigmatisms and calculated the ocular residual astigmatism. We performed multiple quantile regression analysis to evaluate the factors associated with refractive, corneal and ocular residual astigmatisms.

Results

A total of 13,558 subjects (49% female) with a mean age of 54.0 years (range 35–74 years) were included in this study. The prevalence of refractive astigmatism (>1.0D) was 13.0% in right eyes and 12.0% in left eyes, and 85% of these subjects wore spectacles. The distribution of refractive astigmatism showed a two-peak distribution with high astigmatism for with-the-rule and against-the-rule astigmatism. The associated factors were corneal curvature, age and sex for the different astigmatisms (p < 0.001).

Conclusions

We analyzed the prevalence of different astigmatisms within a European population. We confirmed a shift with aging from with-the-rule to against-the-rule astigmatism to refractive and corneal astigmatism. Astigmatism has a large impact on visual perception; more than 85% of people with astigmatism over one diopter wore glasses for distance vision.
Literature
2.
go back to reference Cheng CY, Hsu WM, Liu JH, Tsai SY, Chou P (2003) Refractive errors in an elderly Chinese population in Taiwan: the Shihpai eye study. Invest Ophthalmol Vis Sci 44:4630–4638CrossRefPubMed Cheng CY, Hsu WM, Liu JH, Tsai SY, Chou P (2003) Refractive errors in an elderly Chinese population in Taiwan: the Shihpai eye study. Invest Ophthalmol Vis Sci 44:4630–4638CrossRefPubMed
4.
go back to reference Trindade F, Oliveira A, Frasson M (1997) Benefit of against-the-rule astigmatism to uncorrected near acuity. J Cataract Refract Surg 23:82–85CrossRefPubMed Trindade F, Oliveira A, Frasson M (1997) Benefit of against-the-rule astigmatism to uncorrected near acuity. J Cataract Refract Surg 23:82–85CrossRefPubMed
5.
go back to reference Verzella F, Calossi A (1993) Multifocal effect of against-the-rule myopic astigmatism in pseudophakic eyes. Refract Corneal Surg 9:58–61PubMed Verzella F, Calossi A (1993) Multifocal effect of against-the-rule myopic astigmatism in pseudophakic eyes. Refract Corneal Surg 9:58–61PubMed
7.
go back to reference Sanfilippo PG, Yazar S, Kearns L, Sherwin JC, Hewitt AW, Mackey DA (2015) Distribution of astigmatism as a function of age in an Australian population. Acta Ophthalmol doi. doi:10.1111/aos.12644 Sanfilippo PG, Yazar S, Kearns L, Sherwin JC, Hewitt AW, Mackey DA (2015) Distribution of astigmatism as a function of age in an Australian population. Acta Ophthalmol doi. doi:10.​1111/​aos.​12644
8.
go back to reference Liu YC, Chou P, Wojciechowski R, Lin PY, Liu CJ, Chen SJ, Liu JH, Hsu WM, Cheng CY (2011) Power vector analysis of refractive, corneal, and internal astigmatism in an elderly Chinese population: the Shihpai eye study. Invest Ophthalmol Vis Sci 52:9651–9657. doi:10.1167/iovs.11-7641 CrossRefPubMed Liu YC, Chou P, Wojciechowski R, Lin PY, Liu CJ, Chen SJ, Liu JH, Hsu WM, Cheng CY (2011) Power vector analysis of refractive, corneal, and internal astigmatism in an elderly Chinese population: the Shihpai eye study. Invest Ophthalmol Vis Sci 52:9651–9657. doi:10.​1167/​iovs.​11-7641 CrossRefPubMed
11.
go back to reference Thibos LN, Wheeler W, Horner D (1997) Power vectors: an application of Fourier analysis to the description and statistical analysis of refractive error. Optom Vis Sci 74:367–375CrossRefPubMed Thibos LN, Wheeler W, Horner D (1997) Power vectors: an application of Fourier analysis to the description and statistical analysis of refractive error. Optom Vis Sci 74:367–375CrossRefPubMed
16.
go back to reference Alpins NA (1997) New method of targeting vectors to treat astigmatism. J Cataract Refract Surg 23:65–75CrossRefPubMed Alpins NA (1997) New method of targeting vectors to treat astigmatism. J Cataract Refract Surg 23:65–75CrossRefPubMed
17.
go back to reference Lopes MC, Hysi PG, Verhoeven VJ, Macgregor S, Hewitt AW, Montgomery GW, Cumberland P, Vingerling JR, Young TL, van Duijn CM, Oostra B, Uitterlinden AG, Rahi JS, Mackey DA, Klaver CC, Andrew T, Hammond CJ (2013) Identification of a candidate gene for astigmatism. Invest Ophthalmol Vis Sci 54:1260–1267. doi:10.1167/iovs.12-10463 CrossRefPubMedPubMedCentral Lopes MC, Hysi PG, Verhoeven VJ, Macgregor S, Hewitt AW, Montgomery GW, Cumberland P, Vingerling JR, Young TL, van Duijn CM, Oostra B, Uitterlinden AG, Rahi JS, Mackey DA, Klaver CC, Andrew T, Hammond CJ (2013) Identification of a candidate gene for astigmatism. Invest Ophthalmol Vis Sci 54:1260–1267. doi:10.​1167/​iovs.​12-10463 CrossRefPubMedPubMedCentral
18.
go back to reference Fan Q, Zhou X, Khor CC, Cheng CY, Goh LK, Sim X, Tay WT, Li YJ, Ong RT, Suo C, Cornes B, Ikram MK, Chia KS, Seielstad M, Liu J, Vithana E, Young TL, Tai ES, Wong TY, Aung T, Teo YY, Saw SM (2011) Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. PLoS Genet 7:e1002402. doi:10.1371/journal.pgen.1002402 CrossRefPubMedPubMedCentral Fan Q, Zhou X, Khor CC, Cheng CY, Goh LK, Sim X, Tay WT, Li YJ, Ong RT, Suo C, Cornes B, Ikram MK, Chia KS, Seielstad M, Liu J, Vithana E, Young TL, Tai ES, Wong TY, Aung T, Teo YY, Saw SM (2011) Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. PLoS Genet 7:e1002402. doi:10.​1371/​journal.​pgen.​1002402 CrossRefPubMedPubMedCentral
19.
go back to reference Simpson CL, Wojciechowski R, Oexle K, Murgia F, Portas L, Li X, Verhoeven VJ, Vitart V, Schache M, Hosseini SM, Hysi PG, Raffel LJ, Cotch MF, Chew E, Klein BE, Klein R, Wong TY, van Duijn CM, Mitchell P, Saw SM, Fossarello M, Wang JJ, Polasek O, Campbell H, Rudan I, Oostra BA, Uitterlinden AG, Hofman A, Rivadeneira F, Amin N, Karssen LC, Vingerling JR, Doring A, Bettecken T, Bencic G, Gieger C, Wichmann HE, Wilson JF, Venturini C, Fleck B, Cumberland PM, Rahi JS, Hammond CJ, Hayward C, Wright AF, Paterson AD, Baird PN, Klaver CC, Rotter JI, Pirastu M, Meitinger T, Bailey-Wilson JE, Stambolian D (2014) Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. PLoS One 9:e107110. doi:10.1371/journal.pone.0107110 CrossRefPubMedPubMedCentral Simpson CL, Wojciechowski R, Oexle K, Murgia F, Portas L, Li X, Verhoeven VJ, Vitart V, Schache M, Hosseini SM, Hysi PG, Raffel LJ, Cotch MF, Chew E, Klein BE, Klein R, Wong TY, van Duijn CM, Mitchell P, Saw SM, Fossarello M, Wang JJ, Polasek O, Campbell H, Rudan I, Oostra BA, Uitterlinden AG, Hofman A, Rivadeneira F, Amin N, Karssen LC, Vingerling JR, Doring A, Bettecken T, Bencic G, Gieger C, Wichmann HE, Wilson JF, Venturini C, Fleck B, Cumberland PM, Rahi JS, Hammond CJ, Hayward C, Wright AF, Paterson AD, Baird PN, Klaver CC, Rotter JI, Pirastu M, Meitinger T, Bailey-Wilson JE, Stambolian D (2014) Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. PLoS One 9:e107110. doi:10.​1371/​journal.​pone.​0107110 CrossRefPubMedPubMedCentral
Metadata
Title
Refractive, corneal and ocular residual astigmatism: distribution in a German population and age-dependency - the Gutenberg health study
Authors
Alexander Karl-Georg Schuster
Norbert Pfeiffer
Andreas Schulz
René Hoehn
Katharina A. Ponto
Philipp S. Wild
Maria Blettner
Manfred E. Beutel
Karl J. Lackner
Thomas Münzel
Alireza Mirshahi
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2017
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-017-3775-x

Other articles of this Issue 12/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 12/2017 Go to the issue