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Published in: Current HIV/AIDS Reports 2/2013

01-06-2013 | The Global Epidemic (Q Abdool Karim, Section Editor)

Reducing HIV and AIDS in Adolescents: Opportunities and Challenges

Authors: Susan Kasedde, Chewe Luo, Craig McClure, Upjeet Chandan

Published in: Current HIV/AIDS Reports | Issue 2/2013

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Abstract

Adolescents are critical to efforts to end the AIDS epidemic. Few national AIDS strategies explicitly program for children in their second decade of life. Adolescents (aged 10–19 years) are therefore largely invisible in global, regional, and country HIV and AIDS reports making it difficult to assess progress in this population. We have unprecedented knowledge to guide investment towards greater impact on HIV prevention, treatment, and care in adolescents, but it has not been applied to reach those most vulnerable and optimize efficiency and scale. The cost of this is increasing AIDS-related deaths and largely unchanged levels of new HIV infections in adolescents. An AIDS-free generation will remain out of reach if the global community does not prioritize adolescents. National AIDS responses must be accountable to adolescents, invest in strengthening and monitoring protective and supportive laws and policies and access for adolescents to high impact HIV interventions.
Literature
1.
go back to reference WHO: The second decade: improving adolescent health and development. Department of Child and Adolescent Health and Development. Geneva: WHO. 2001. WHO: The second decade: improving adolescent health and development. Department of Child and Adolescent Health and Development. Geneva: WHO. 2001.
2.
go back to reference Patton G, McMorris BJ, Toumbourou JW, et al. Puberty and the onset of substance use. Pediatrics. 2004;114:300–6.CrossRef Patton G, McMorris BJ, Toumbourou JW, et al. Puberty and the onset of substance use. Pediatrics. 2004;114:300–6.CrossRef
3.
go back to reference WHO, UNFPA, and UNAIDS. Seen but not heard: very young adolescents aged 10–14 years. Geneva: UNAIDS. 2004. WHO, UNFPA, and UNAIDS. Seen but not heard: very young adolescents aged 10–14 years. Geneva: UNAIDS. 2004.
4.
go back to reference Viner RM, Ozer EM, Denny S, et al. Adolescence and the social determinants of health. Lancet. 2012;379:1641–52.PubMedCrossRef Viner RM, Ozer EM, Denny S, et al. Adolescence and the social determinants of health. Lancet. 2012;379:1641–52.PubMedCrossRef
5.
go back to reference UNICEF. Opportunity in crisis: Preventing HIV from early adolescence to early adulthood. New York: UNICEF; 2011. UNICEF. Opportunity in crisis: Preventing HIV from early adolescence to early adulthood. New York: UNICEF; 2011.
6.
go back to reference UNICEF. Progress for children: A report card on adolescents. New York: UNICEF; 2012. UNICEF. Progress for children: A report card on adolescents. New York: UNICEF; 2012.
7.
go back to reference WHO. Early marriages, adolescent, and young pregnancies, WHO Report to the 65th World Health Assembly. 2012. WHO. Early marriages, adolescent, and young pregnancies, WHO Report to the 65th World Health Assembly. 2012.
8.
go back to reference WHO Fact Sheet No 364. Adolescent pregnancy. 2012. WHO Fact Sheet No 364. Adolescent pregnancy. 2012.
9.
go back to reference UNAIDS. Global report: UNAIDS report on the global AIDS epidemic 2012. Geneva: UNAIDS; 2012. UNAIDS. Global report: UNAIDS report on the global AIDS epidemic 2012. Geneva: UNAIDS; 2012.
10.
go back to reference UNAIDS. Unpublished 2011 Estimates. Geneva: UNAIDS. 2012. UNAIDS. Unpublished 2011 Estimates. Geneva: UNAIDS. 2012.
11.
go back to reference UNICEF, Blame and Banishment. The underground HIV epidemic affecting children in Eastern Europe and Central Asia. Switzerland: UNICEF. 2010. UNICEF, Blame and Banishment. The underground HIV epidemic affecting children in Eastern Europe and Central Asia. Switzerland: UNICEF. 2010.
14.
go back to reference Beyrer C, Baral S, van Griensven F, et al. Global epidemiology of HIV infection in men who have sex with men. Lancet. 2012;380:367–77.PubMedCrossRef Beyrer C, Baral S, van Griensven F, et al. Global epidemiology of HIV infection in men who have sex with men. Lancet. 2012;380:367–77.PubMedCrossRef
15.
go back to reference Millett G, Jeffries IV WL, Peterson JL, et al. Common roots: a contextual review of HIV epidemics in black men who have sex with men across the African diaspora. Lancet. 2012;380:411–23.PubMedCrossRef Millett G, Jeffries IV WL, Peterson JL, et al. Common roots: a contextual review of HIV epidemics in black men who have sex with men across the African diaspora. Lancet. 2012;380:411–23.PubMedCrossRef
16.
go back to reference US Centers for Disease Control and Prevention, HIV Among Youth in the US: protecting a generation, in CDC vital signs. November 2012. US Centers for Disease Control and Prevention, HIV Among Youth in the US: protecting a generation, in CDC vital signs. November 2012.
17.
go back to reference Birdthistle I, Dringus S, Knight L, et al. Investing in young people: a review of national-level spending on HIV prevention for young people aged 10–24 in 16 high-prevalence countries. Presented at the XIX International AIDS Conference. Washington DC, United States of America. 2012. Birdthistle I, Dringus S, Knight L, et al. Investing in young people: a review of national-level spending on HIV prevention for young people aged 10–24 in 16 high-prevalence countries. Presented at the XIX International AIDS Conference. Washington DC, United States of America. 2012.
18.
go back to reference • Deogan C, Ferguson J, Stenberg K. Resource needs for adolescent friendly health services: estimates for 74 low- and middle-income countries. PLoS One. 2012;7:e51420. Estimates additional resource needs for scaling up health service delivery to adolescents to achieve MDG 4, 5, and 6 by 2015, indicating a substantial investment gap in the adolescent HIV and health response in low and middle income countries.PubMedCrossRef • Deogan C, Ferguson J, Stenberg K. Resource needs for adolescent friendly health services: estimates for 74 low- and middle-income countries. PLoS One. 2012;7:e51420. Estimates additional resource needs for scaling up health service delivery to adolescents to achieve MDG 4, 5, and 6 by 2015, indicating a substantial investment gap in the adolescent HIV and health response in low and middle income countries.PubMedCrossRef
19.
go back to reference •• Schwartlander B, Stover J, Hallett T, et al. Towards an improved investment approach for an effective response to HIV/AIDS. Lancet. 2011;377:2031–41. Makes a strong, evidence-based argument for a more targeted and strategic investment approach to reduce HIV risk, transmission, morbidity, and mortality, with broad-based population impacts.PubMedCrossRef •• Schwartlander B, Stover J, Hallett T, et al. Towards an improved investment approach for an effective response to HIV/AIDS. Lancet. 2011;377:2031–41. Makes a strong, evidence-based argument for a more targeted and strategic investment approach to reduce HIV risk, transmission, morbidity, and mortality, with broad-based population impacts.PubMedCrossRef
20.
go back to reference Guttmacher Institute and IPPF. In brief: Facts on the sexual and reproductive health of adolescent women in the developing world. New York: Guttmacher Institute; 2010. Guttmacher Institute and IPPF. In brief: Facts on the sexual and reproductive health of adolescent women in the developing world. New York: Guttmacher Institute; 2010.
21.
go back to reference Sweeney S, Obure CD, Maier CB, et al. Costs and efficiency of integrating HIV/AIDS services with other health services: a systematic review of evidence and experience. Sex Transm Infect. 2012;88:85–99.PubMedCrossRef Sweeney S, Obure CD, Maier CB, et al. Costs and efficiency of integrating HIV/AIDS services with other health services: a systematic review of evidence and experience. Sex Transm Infect. 2012;88:85–99.PubMedCrossRef
22.
go back to reference Fortenberry JD, Martinez J, Rudy BJ, Monte D. Linkage to care for HIV-positive adolescents: a multi-site study of the Adolescent Medicine Trials Unit of the Adolescent Trials Network. J Adolesc Health. 2012;51:551–6.PubMedCrossRef Fortenberry JD, Martinez J, Rudy BJ, Monte D. Linkage to care for HIV-positive adolescents: a multi-site study of the Adolescent Medicine Trials Unit of the Adolescent Trials Network. J Adolesc Health. 2012;51:551–6.PubMedCrossRef
23.
go back to reference Kenny J, Mulenga V, Hoskins S, et al. The needs for HIV treatment and care of children, adolescents, pregnant women, and older people in low-income and middle-income countries. AIDS 2012;(Suppl 2):S105–16. Kenny J, Mulenga V, Hoskins S, et al. The needs for HIV treatment and care of children, adolescents, pregnant women, and older people in low-income and middle-income countries. AIDS 2012;(Suppl 2):S105–16.
24.
go back to reference Leclerc-Madlala S. Age-disparate and intergenerational sex in southern Africa: the dynamics of hypervulnerability. AIDS. 2008;22 Suppl 4:S17–25.PubMedCrossRef Leclerc-Madlala S. Age-disparate and intergenerational sex in southern Africa: the dynamics of hypervulnerability. AIDS. 2008;22 Suppl 4:S17–25.PubMedCrossRef
25.
go back to reference Underwood C, Skinner J, Osman N, Schwandt H. Structural determinants of adolescent girls’ vulnerability to HIV: views from community members in Botswana, Malawi, and Mozambique. Soc Sci Med. 2011;73:343–50.PubMedCrossRef Underwood C, Skinner J, Osman N, Schwandt H. Structural determinants of adolescent girls’ vulnerability to HIV: views from community members in Botswana, Malawi, and Mozambique. Soc Sci Med. 2011;73:343–50.PubMedCrossRef
26.
go back to reference •• Baird S, Garfein R, Mcintosh C, Ozler B. Effect of a cash transfer program for schooling on prevalence of HIV and herpes simplex type 2 in Malawi: a cluster randomized trial. Lancet. 2012;379:1320–9. Demonstrates how cash transfer programs (structural intervention) that do not directly target sexual behavior can reduce HIV and HSV-2 infections in adolescent schoolgirls in low income settings.PubMedCrossRef •• Baird S, Garfein R, Mcintosh C, Ozler B. Effect of a cash transfer program for schooling on prevalence of HIV and herpes simplex type 2 in Malawi: a cluster randomized trial. Lancet. 2012;379:1320–9. Demonstrates how cash transfer programs (structural intervention) that do not directly target sexual behavior can reduce HIV and HSV-2 infections in adolescent schoolgirls in low income settings.PubMedCrossRef
27.
go back to reference Andersson N, Paredes-Solís S, Milne D, et al. Prevalence and risk factors for forced or coerced sex among school-going youth: national cross-sectional studies in 10 southern African countries in 2003 and 2007. BMJ Open. 2012;2:e000754. doi:10.1136/bmjopen-2011-000754.PubMedCrossRef Andersson N, Paredes-Solís S, Milne D, et al. Prevalence and risk factors for forced or coerced sex among school-going youth: national cross-sectional studies in 10 southern African countries in 2003 and 2007. BMJ Open. 2012;2:e000754. doi:10.​1136/​bmjopen-2011-000754.PubMedCrossRef
28.
go back to reference Andersson N, Cockroft A. Gender-based violence and HIV: relevance for HIV prevention in hyperendemic countries of southern Africa. AIDS. 2008;22 Suppl 4:S73–86.PubMedCrossRef Andersson N, Cockroft A. Gender-based violence and HIV: relevance for HIV prevention in hyperendemic countries of southern Africa. AIDS. 2008;22 Suppl 4:S73–86.PubMedCrossRef
29.
go back to reference Merkinaite S, Grund JP, Frimpong A. Young people and drugs: next generation of harm reduction. Int J Drug Policy. 2010;21:112–4.PubMedCrossRef Merkinaite S, Grund JP, Frimpong A. Young people and drugs: next generation of harm reduction. Int J Drug Policy. 2010;21:112–4.PubMedCrossRef
31.
go back to reference European Bank for Reconstruction and Development, Transition report. Energy in transition - economic transition in central and eastern Europe, the Baltic states, and the CIS. EBRD: London; 2001. European Bank for Reconstruction and Development, Transition report. Energy in transition - economic transition in central and eastern Europe, the Baltic states, and the CIS. EBRD: London; 2001.
32.
go back to reference Hillis SD, Zapata L, Robbins CL, et al. HIV seroprevalence among orphaned and homeless youth: no place like home. AIDS. 2012;26:105–10.PubMedCrossRef Hillis SD, Zapata L, Robbins CL, et al. HIV seroprevalence among orphaned and homeless youth: no place like home. AIDS. 2012;26:105–10.PubMedCrossRef
33.
go back to reference Robbins CL, Zapata L, Kissin DM, et al. Multicity HIV seroprevalence in street youth, Ukraine. Int J STD AIDS. 2010;21:489–96.PubMedCrossRef Robbins CL, Zapata L, Kissin DM, et al. Multicity HIV seroprevalence in street youth, Ukraine. Int J STD AIDS. 2010;21:489–96.PubMedCrossRef
34.
go back to reference Kissin DM, Zapata L, Yorick R, et al. HIV seroprevalence in street youth, St. Petersburg, Russia. AIDS. 2007;21:2333–40.PubMedCrossRef Kissin DM, Zapata L, Yorick R, et al. HIV seroprevalence in street youth, St. Petersburg, Russia. AIDS. 2007;21:2333–40.PubMedCrossRef
35.
go back to reference Thorne C, Semenenko I, Malyuta R. Prevention of mother-to-child transmission of human immunodeficiency virus among pregnant women using injecting drugs in Ukraine, 2000–10. Addiction. 2012;107:118–28.PubMedCrossRef Thorne C, Semenenko I, Malyuta R. Prevention of mother-to-child transmission of human immunodeficiency virus among pregnant women using injecting drugs in Ukraine, 2000–10. Addiction. 2012;107:118–28.PubMedCrossRef
36.
go back to reference Silverman JG. Adolescent female sex workers: invisibility, violence, and HIV. Arch Dis Child. 2011;96:478–81.PubMedCrossRef Silverman JG. Adolescent female sex workers: invisibility, violence, and HIV. Arch Dis Child. 2011;96:478–81.PubMedCrossRef
37.
go back to reference Zhang XD, Temmerman M, Li Y, et al. Vulnerabilities, health needs, and predictors of high-risk sexual behavior among female adolescent sex workers in Kunming, China. Sex Transm Infect. 2012;1–8. Zhang XD, Temmerman M, Li Y, et al. Vulnerabilities, health needs, and predictors of high-risk sexual behavior among female adolescent sex workers in Kunming, China. Sex Transm Infect. 2012;1–8.
38.
go back to reference FHI, Young People Most at Risk of HIV. A meeting report and discussion paper from the Interagency Working Group, U.S. Agency for International Development, the Joint United Nations Programme on HIV/AIDS (UNAIDS) Inter-Agency Task Team on HIV, and Young People, and FHI. FHI: Research Triangle Park. 2010. FHI, Young People Most at Risk of HIV. A meeting report and discussion paper from the Interagency Working Group, U.S. Agency for International Development, the Joint United Nations Programme on HIV/AIDS (UNAIDS) Inter-Agency Task Team on HIV, and Young People, and FHI. FHI: Research Triangle Park. 2010.
39.
go back to reference Smyrnov P, Broadhead RS, Datsenko O, Matiyash O. Rejuvenating harm reduction projects for injection drug users: Ukraine's nationwide introduction of peer-driven interventions. Int J Drug Policy. 2012;23:141–7.PubMedCrossRef Smyrnov P, Broadhead RS, Datsenko O, Matiyash O. Rejuvenating harm reduction projects for injection drug users: Ukraine's nationwide introduction of peer-driven interventions. Int J Drug Policy. 2012;23:141–7.PubMedCrossRef
40.
go back to reference Nachega JB, Hislop M, Nguyen H, et al. Antiretroviral therapy adherence, virologic, and immunologic outcomes in adolescents compared with adults in southern Africa. J Acquir Immune Defic Syndr. 2009;51:65–71.PubMedCrossRef Nachega JB, Hislop M, Nguyen H, et al. Antiretroviral therapy adherence, virologic, and immunologic outcomes in adolescents compared with adults in southern Africa. J Acquir Immune Defic Syndr. 2009;51:65–71.PubMedCrossRef
42.
go back to reference Birungi H, Mugisha JF, Obare F, Nyombi JK. Sexual behavior and desires among adolescents perinatally infected with human immunodeficiency virus in Uganda: implications for programming. J Adolesc Health. 2009;44:184–7.PubMedCrossRef Birungi H, Mugisha JF, Obare F, Nyombi JK. Sexual behavior and desires among adolescents perinatally infected with human immunodeficiency virus in Uganda: implications for programming. J Adolesc Health. 2009;44:184–7.PubMedCrossRef
43.
go back to reference Birungi H, Obare F, Mugisha JF, et al. Preventive service needs of young people perinatally infected with HIV in Uganda. AIDS Care. 2009;21:725–31.PubMedCrossRef Birungi H, Obare F, Mugisha JF, et al. Preventive service needs of young people perinatally infected with HIV in Uganda. AIDS Care. 2009;21:725–31.PubMedCrossRef
44.
go back to reference Hodgson I, Ross J, Haamujompa C, Gitau-Mburu D. Living as an adolescent with HIV in Zambia–lived experiences, sexual health, and reproductive needs. AIDS Care. 2012;24:1204–10.PubMedCrossRef Hodgson I, Ross J, Haamujompa C, Gitau-Mburu D. Living as an adolescent with HIV in Zambia–lived experiences, sexual health, and reproductive needs. AIDS Care. 2012;24:1204–10.PubMedCrossRef
45.
go back to reference Ferrand RA, Bandason T, Musvaire P. Causes of acute hospitalization in adolescence: burden and spectrum of HIV-related morbidity in a country with an early-onset and severe HIV epidemic: a prospective survey. PLoS Med. 2010;7:e1000178. doi:10.1371/journal.pmed.1000178.PubMedCrossRef Ferrand RA, Bandason T, Musvaire P. Causes of acute hospitalization in adolescence: burden and spectrum of HIV-related morbidity in a country with an early-onset and severe HIV epidemic: a prospective survey. PLoS Med. 2010;7:e1000178. doi:10.​1371/​journal.​pmed.​1000178.PubMedCrossRef
46.
go back to reference •• Ferrand RA, Munaiwa L, Matsekete J, et al. Undiagnosed HIV infection among adolescents seeking primary health care in Zimbabwe. Clin Infect Dis. 2010;51:844–51. Reports high rates of undiagnosed HIV infection among adolescents seeking primary health care in Zimbabwe, emphasizing the importance of routine HIV testing and counselling at the primary care level to identify vertically-infected adolescents (‘slow progressors’ ) and link them to treatment and care.PubMedCrossRef •• Ferrand RA, Munaiwa L, Matsekete J, et al. Undiagnosed HIV infection among adolescents seeking primary health care in Zimbabwe. Clin Infect Dis. 2010;51:844–51. Reports high rates of undiagnosed HIV infection among adolescents seeking primary health care in Zimbabwe, emphasizing the importance of routine HIV testing and counselling at the primary care level to identify vertically-infected adolescents (‘slow progressors’ ) and link them to treatment and care.PubMedCrossRef
47.
go back to reference Binagwaho A, Fuller A, Farmer P, et al. Adolescents and the right to health: eliminating age-related barriers to HIV/AIDS services in Rwanda. AIDS Care. 2012;24:936–42.PubMedCrossRef Binagwaho A, Fuller A, Farmer P, et al. Adolescents and the right to health: eliminating age-related barriers to HIV/AIDS services in Rwanda. AIDS Care. 2012;24:936–42.PubMedCrossRef
48.
go back to reference Ferrand RA, Trigg C, Bandason T, et al. Perception of risk of vertically acquired HIV infection and acceptability of provider-initiated testing and counselling among adolescents in Zimbabwe. Am J Public Health. 2011;01:2325–32.CrossRef Ferrand RA, Trigg C, Bandason T, et al. Perception of risk of vertically acquired HIV infection and acceptability of provider-initiated testing and counselling among adolescents in Zimbabwe. Am J Public Health. 2011;01:2325–32.CrossRef
49.
go back to reference van Rooyen H, McGrath N, Chirowodza A, et al. Mobile VCT. Reaching men and young people in urban and rural South African pilot studies (NIMH Project Accept, HPTN 043). AIDS Behav. 2012;[epub ahead of print]. van Rooyen H, McGrath N, Chirowodza A, et al. Mobile VCT. Reaching men and young people in urban and rural South African pilot studies (NIMH Project Accept, HPTN 043). AIDS Behav. 2012;[epub ahead of print].
50.
go back to reference Ramirez-Avila L, Nixon K, Noubary F, et al. Routine HIV testing in adolescents and young adults presenting to an outpatient clinic in Durban, South Africa. PLoS One. 2012;7:e45507.PubMedCrossRef Ramirez-Avila L, Nixon K, Noubary F, et al. Routine HIV testing in adolescents and young adults presenting to an outpatient clinic in Durban, South Africa. PLoS One. 2012;7:e45507.PubMedCrossRef
51.
go back to reference Li R, Jaspan H, O'Brien V, et al. Positive futures: a qualitative study on the needs of adolescents on antiretroviral therapy in South Africa. AIDS Care. 2010;22:751–8.PubMedCrossRef Li R, Jaspan H, O'Brien V, et al. Positive futures: a qualitative study on the needs of adolescents on antiretroviral therapy in South Africa. AIDS Care. 2010;22:751–8.PubMedCrossRef
52.
go back to reference Dowshen N, D'Angelo L. Health care transition for youth living with HIV/AIDS. Pediatrics. 2011;128:762–71.PubMedCrossRef Dowshen N, D'Angelo L. Health care transition for youth living with HIV/AIDS. Pediatrics. 2011;128:762–71.PubMedCrossRef
53.
go back to reference Koenig LJ, Nesheim S, Abramowitz S. Adolescents with perinatally acquired HIV: emerging behavioral and health needs for long-term survivors. Curr Opin Obstet Gynecol. 2011;23:321–7.PubMedCrossRef Koenig LJ, Nesheim S, Abramowitz S. Adolescents with perinatally acquired HIV: emerging behavioral and health needs for long-term survivors. Curr Opin Obstet Gynecol. 2011;23:321–7.PubMedCrossRef
54.
go back to reference Kim J, Pronyk J, Barnett T, Watts C. Exploring the role of economic empowerment in HIV prevention. AIDS. 2008;22 Suppl 4:S57–71.PubMedCrossRef Kim J, Pronyk J, Barnett T, Watts C. Exploring the role of economic empowerment in HIV prevention. AIDS. 2008;22 Suppl 4:S57–71.PubMedCrossRef
55.
go back to reference Chersich MF, Rees HV. Vulnerability of women in southern Africa to infection with HIV: biological determinants and priority health sector interventions. AIDS. 2008;22 Suppl 4:S27–40.PubMedCrossRef Chersich MF, Rees HV. Vulnerability of women in southern Africa to infection with HIV: biological determinants and priority health sector interventions. AIDS. 2008;22 Suppl 4:S27–40.PubMedCrossRef
56.
go back to reference Interagency Task Team on HIV and Young People Guidance Brief. HIV Interventions for Most-at-Risk Young People. New York: UNFPA. 2009. Interagency Task Team on HIV and Young People Guidance Brief. HIV Interventions for Most-at-Risk Young People. New York: UNFPA. 2009.
57.
go back to reference Bailey C, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomized controlled trial. Lancet. 2007;369:643–56.PubMedCrossRef Bailey C, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomized controlled trial. Lancet. 2007;369:643–56.PubMedCrossRef
58.
go back to reference Gray H, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in young men in Rakai, Uganda: a randomized trial. Lancet. 2007;369:657–66.PubMedCrossRef Gray H, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in young men in Rakai, Uganda: a randomized trial. Lancet. 2007;369:657–66.PubMedCrossRef
59.
go back to reference Auvert B, Taljaard D, Lagarde E, et al. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2:e298.PubMedCrossRef Auvert B, Taljaard D, Lagarde E, et al. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2:e298.PubMedCrossRef
60.
go back to reference World Health Organization. Effectiveness of sterile needle and syringe programming in reducing HIV/AIDS among injecting drug users. Geneva: WHO; 2004. World Health Organization. Effectiveness of sterile needle and syringe programming in reducing HIV/AIDS among injecting drug users. Geneva: WHO; 2004.
61.
go back to reference •• Grant RL, Grant RM, Lama JR, Anderson PL, et al. Pre-exposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587–99. Article presents findings from the first successful trial testing the proof of concept of use of oral daily combination pre-exposure prophylaxis in 2 high risk populations (MSM and transgender women).PubMedCrossRef •• Grant RL, Grant RM, Lama JR, Anderson PL, et al. Pre-exposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587–99. Article presents findings from the first successful trial testing the proof of concept of use of oral daily combination pre-exposure prophylaxis in 2 high risk populations (MSM and transgender women).PubMedCrossRef
62.
go back to reference WHO. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: Recommendations for a public health approach. Geneva: WHO; 2010. WHO. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: Recommendations for a public health approach. Geneva: WHO; 2010.
63.
go back to reference Cohen MS, Gay CL. Treatment to prevent transmission of HIV-1. Clin Infect Dis. 2010;50 Suppl. 3:S85–95.PubMedCrossRef Cohen MS, Gay CL. Treatment to prevent transmission of HIV-1. Clin Infect Dis. 2010;50 Suppl. 3:S85–95.PubMedCrossRef
64.
go back to reference •• Cohen MS, McCauley M, Gamble TR. HIV treatment as prevention and HPTN 052. Curr Opin HIV AIDS. 2012;7:99–105. Article describes the seminal randomized controlled trial proving 96 % reduction in sexual transmission of HIV in sero-discordant heterosexual couples through the use of antiretroviral therapy.PubMedCrossRef •• Cohen MS, McCauley M, Gamble TR. HIV treatment as prevention and HPTN 052. Curr Opin HIV AIDS. 2012;7:99–105. Article describes the seminal randomized controlled trial proving 96 % reduction in sexual transmission of HIV in sero-discordant heterosexual couples through the use of antiretroviral therapy.PubMedCrossRef
65.
go back to reference Shepherd J, Kavanagh J, Picot, J, et al. The effectiveness and cost-effectiveness of behavioral interventions for the prevention of sexually transmitted infections in young people aged 13–19: a systematic review and economic evaluation, Health Technology Assessment. 2010:14. Shepherd J, Kavanagh J, Picot, J, et al. The effectiveness and cost-effectiveness of behavioral interventions for the prevention of sexually transmitted infections in young people aged 13–19: a systematic review and economic evaluation, Health Technology Assessment. 2010:14.
66.
go back to reference Vidanapathirana J, Abramson MJ, Forbes A, Fairley C. Mass media interventions for promoting HIV testing. Cochrane Database Syst Rev. 2005;3:CD004775.PubMed Vidanapathirana J, Abramson MJ, Forbes A, Fairley C. Mass media interventions for promoting HIV testing. Cochrane Database Syst Rev. 2005;3:CD004775.PubMed
67.
go back to reference •• Karim QA, Karim SSA, et al. Effectiveness and safety of Tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168–74. Article presents the findings of the first successful trial showing that the use of Tenofovir based vaginal microbicide gel reduced the risk of HIV acquisition by 39 % including some as young as 18. The gel had a higher effectiveness (54 %) in women who adhered to the guidelines provided.CrossRef •• Karim QA, Karim SSA, et al. Effectiveness and safety of Tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168–74. Article presents the findings of the first successful trial showing that the use of Tenofovir based vaginal microbicide gel reduced the risk of HIV acquisition by 39 % including some as young as 18. The gel had a higher effectiveness (54 %) in women who adhered to the guidelines provided.CrossRef
68.
go back to reference Celum C, Baeten JM. Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence. Curr Opin Infect Dis. 2012;25:51–7.PubMedCrossRef Celum C, Baeten JM. Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence. Curr Opin Infect Dis. 2012;25:51–7.PubMedCrossRef
70.
go back to reference WHO (2006) Global estimates of health consequences due to violence against children. Background paper to the UN Secretary-General’s Study on Violence against Children. Geneva, World Health Organization, based on estimates by Andrews G, et al. (2004). Child Sexual Abuse. Ch. 23 in Ezzati M, et al. (2004). Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors, Vol 2. Geneva, World Health Organization, pp. 1851–940, and using UN Population Division data for the population under 18 years. WHO (2006) Global estimates of health consequences due to violence against children. Background paper to the UN Secretary-General’s Study on Violence against Children. Geneva, World Health Organization, based on estimates by Andrews G, et al. (2004). Child Sexual Abuse. Ch. 23 in Ezzati M, et al. (2004). Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors, Vol 2. Geneva, World Health Organization, pp. 1851–940, and using UN Population Division data for the population under 18 years.
71.
go back to reference Strode A, Grant K. Children and HIV: using an evidence-based approach to identifying legal strategies that protect and promote the right of children infected and affected by HIV and AIDS, Working paper prepared for the Third Meeting of the Technical Advisory Group of the Global Commission on HIV and the Law. 2011. Strode A, Grant K. Children and HIV: using an evidence-based approach to identifying legal strategies that protect and promote the right of children infected and affected by HIV and AIDS, Working paper prepared for the Third Meeting of the Technical Advisory Group of the Global Commission on HIV and the Law. 2011.
72.
go back to reference Ferrand R, Lowe S, et al. Survey of children accessing HIV services in a high HIV prevalence setting: time for HIV-infected adolescents to count? Bull WHO 2010;6:428–34. Ferrand R, Lowe S, et al. Survey of children accessing HIV services in a high HIV prevalence setting: time for HIV-infected adolescents to count? Bull WHO 2010;6:428–34.
73.
go back to reference Fay H, Baral SD, et al. Stigma, health care access, and HIV knowledge among men who have sex with men in Malawi, Namibia, and Botswana. AIDS Behav. 2011;15:1088–97.PubMedCrossRef Fay H, Baral SD, et al. Stigma, health care access, and HIV knowledge among men who have sex with men in Malawi, Namibia, and Botswana. AIDS Behav. 2011;15:1088–97.PubMedCrossRef
74.
go back to reference Baral S, Sifakis F, et al. Elevated risk for HIV infection among men who have sex with men in low- and middle income countries 2000–2006: a systematic review. PLoS Med. 2007;4:e339.PubMedCrossRef Baral S, Sifakis F, et al. Elevated risk for HIV infection among men who have sex with men in low- and middle income countries 2000–2006: a systematic review. PLoS Med. 2007;4:e339.PubMedCrossRef
75.
go back to reference Baral SD, Poteat T, et al. Worldwide burden of HIV in transgender women: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13:214–22.PubMedCrossRef Baral SD, Poteat T, et al. Worldwide burden of HIV in transgender women: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13:214–22.PubMedCrossRef
76.
go back to reference Sullivan PS, Carballo-Dieguez A, et al. Successes and challenges of HIV prevention in men who have sex with men. Lancet. 2012;380:388–99.PubMedCrossRef Sullivan PS, Carballo-Dieguez A, et al. Successes and challenges of HIV prevention in men who have sex with men. Lancet. 2012;380:388–99.PubMedCrossRef
77.
go back to reference Baggaley RF, White RG, et al. HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention. Int J Epidemiol. 2010;39:1048–63.PubMedCrossRef Baggaley RF, White RG, et al. HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention. Int J Epidemiol. 2010;39:1048–63.PubMedCrossRef
78.
go back to reference WHO. Guidelines: Prevention and treatment of HIV and other sexually transmitted infections among men who have sex with men and transgender people: Recommendations for a public health approach. 2011. WHO. Guidelines: Prevention and treatment of HIV and other sexually transmitted infections among men who have sex with men and transgender people: Recommendations for a public health approach. 2011.
Metadata
Title
Reducing HIV and AIDS in Adolescents: Opportunities and Challenges
Authors
Susan Kasedde
Chewe Luo
Craig McClure
Upjeet Chandan
Publication date
01-06-2013
Publisher
Current Science Inc.
Published in
Current HIV/AIDS Reports / Issue 2/2013
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-013-0159-7

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