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Published in: Calcified Tissue International 6/2008

01-12-2008 | Editorial

Redefining Osteoporosis

Author: B. E. Christopher Nordin

Published in: Calcified Tissue International | Issue 6/2008

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Excerpt

The current widely used definition of osteoporosis is that it is “a systemic skeletal disease characterised by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.” This definition, attributed to a consensus statement in 1993 [1], was confirmed by a World Health Organization (WHO) study group in 1994 [2] and used by the vice chair of that study group in his book published in the same year [3]. Despite this powerful advocacy, it does not in fact meet the requirement of a definition, which needs to be absolutely specific. The definition of anemia is a reduced level of hemoglobin in the blood; it does not include a description of the causes or consequences. The definition of hypertension is a raised blood pressure; it does not mention stroke or heart attacks. The definition of osteoporosis should be equally tight; the causes and consequences are irrelevant. The term “osteoporosis” should identify the essential feature common to all types of osteoporosis which is not present in any other condition that is not osteoporosis. …
Literature
1.
go back to reference Consensus Development Conference (1993) Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94:646–650CrossRef Consensus Development Conference (1993) Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94:646–650CrossRef
2.
go back to reference World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Technical Report Series 843. World Health Organization, Geneva World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Technical Report Series 843. World Health Organization, Geneva
3.
go back to reference Kanis JA (1994) Osteoporosis. Blackwell Science, London Kanis JA (1994) Osteoporosis. Blackwell Science, London
4.
go back to reference World Health Organization (2003) Prevention and management of osteoporosis. Technical Report Series 921. World Health Organization, Geneva World Health Organization (2003) Prevention and management of osteoporosis. Technical Report Series 921. World Health Organization, Geneva
5.
go back to reference Nordin BEC (2008) Reflections on osteoporosis. In: Marcus R, Feldman D, Nelson DA, Rosen CJ (eds) Osteoporosis, vol 1, 3rd edn. Elsevier Academic Press, San Diego, pp 47–69 Nordin BEC (2008) Reflections on osteoporosis. In: Marcus R, Feldman D, Nelson DA, Rosen CJ (eds) Osteoporosis, vol 1, 3rd edn. Elsevier Academic Press, San Diego, pp 47–69
6.
go back to reference Albright F, Reifenstein EC (1948) The parathyroid glands and metabolic bone disease. Williams & Wilkins, Baltimore Albright F, Reifenstein EC (1948) The parathyroid glands and metabolic bone disease. Williams & Wilkins, Baltimore
7.
go back to reference Trotter M, Broman GE, Peterson RR (1960) Densities of bones of white and negro skeletons. J Bone Joint Surg Am 42A:50–58 Trotter M, Broman GE, Peterson RR (1960) Densities of bones of white and negro skeletons. J Bone Joint Surg Am 42A:50–58
8.
go back to reference Qiu S, Tao DS, Palnitkar S, Parfitt AM (2006) Independent and combined contributions of cancellous and cortical bone deficits to vertebral fracture risk in postmenopausal women. J Bone Miner Res 21:1791–1796PubMedCrossRef Qiu S, Tao DS, Palnitkar S, Parfitt AM (2006) Independent and combined contributions of cancellous and cortical bone deficits to vertebral fracture risk in postmenopausal women. J Bone Miner Res 21:1791–1796PubMedCrossRef
9.
10.
go back to reference Kanis JA, Glüer C-C (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192–202PubMedCrossRef Kanis JA, Glüer C-C (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192–202PubMedCrossRef
11.
go back to reference Stone KL, Seeley DG, Lui L-Y, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 18:1947–1954PubMedCrossRef Stone KL, Seeley DG, Lui L-Y, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 18:1947–1954PubMedCrossRef
12.
go back to reference Prentice A (2004) Diet, nutrition and the prevention of osteoporosis. Public Health Nutr 7:227–243PubMedCrossRef Prentice A (2004) Diet, nutrition and the prevention of osteoporosis. Public Health Nutr 7:227–243PubMedCrossRef
13.
go back to reference Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB et al (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320–323PubMedCrossRef Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB et al (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320–323PubMedCrossRef
14.
go back to reference Davis JW, Grove JS, Wasnich RD, Ross PD (1999) Spatial relationships between prevalent and incident spine fractures. Bone 24:261–264PubMedCrossRef Davis JW, Grove JS, Wasnich RD, Ross PD (1999) Spatial relationships between prevalent and incident spine fractures. Bone 24:261–264PubMedCrossRef
15.
go back to reference Tucker G, Metcalfe A, Pearce C, Need AG, Dick IM, Prince RL, Nordin BEC (2007) The importance of calculating absolute rather than relative fracture risk. Bone 41:937–941PubMedCrossRef Tucker G, Metcalfe A, Pearce C, Need AG, Dick IM, Prince RL, Nordin BEC (2007) The importance of calculating absolute rather than relative fracture risk. Bone 41:937–941PubMedCrossRef
16.
go back to reference Johnell O, Oden A, Caulin F, Kanis JA (2001) Acute and long-term increase in fracture risk after hospitalization for vertebral fracture. Osteoporos Int 12:207–214PubMedCrossRef Johnell O, Oden A, Caulin F, Kanis JA (2001) Acute and long-term increase in fracture risk after hospitalization for vertebral fracture. Osteoporos Int 12:207–214PubMedCrossRef
17.
go back to reference Järvinen TLN, Sievänen H, Khan KM (2008) Shifting the focus in fracture prevention from osteoporosis to falls. BMJ 336:124–126PubMedCrossRef Järvinen TLN, Sievänen H, Khan KM (2008) Shifting the focus in fracture prevention from osteoporosis to falls. BMJ 336:124–126PubMedCrossRef
18.
go back to reference Lu Y, Genant HK, Shepherd J, Zhao S, Mathur A, Fuerst TP, Cummings SR (2001) Classification of osteoporosis based on bone mineral densities. J Bone Miner Res 16:901–910PubMedCrossRef Lu Y, Genant HK, Shepherd J, Zhao S, Mathur A, Fuerst TP, Cummings SR (2001) Classification of osteoporosis based on bone mineral densities. J Bone Miner Res 16:901–910PubMedCrossRef
19.
go back to reference Black DM, Cummings SR, Genant HK, Nevitt MC, Palermo L, Browner W (1992) Axial and appendicular bone density predict fractures in older women. J Bone Miner Res 7:633–638PubMedCrossRef Black DM, Cummings SR, Genant HK, Nevitt MC, Palermo L, Browner W (1992) Axial and appendicular bone density predict fractures in older women. J Bone Miner Res 7:633–638PubMedCrossRef
20.
go back to reference Reid IR, Plank LD, Evans MC (1992) Fat mass is an important determinant of whole body bone density in premenopausal women but not in men. J Clin Endocrinol Metab 75:779–782PubMedCrossRef Reid IR, Plank LD, Evans MC (1992) Fat mass is an important determinant of whole body bone density in premenopausal women but not in men. J Clin Endocrinol Metab 75:779–782PubMedCrossRef
21.
go back to reference Duan Y, Parfitt AM, Seeman E (1999) Vertebral bone mass, size, and volumetric density in women with spinal fractures. J Bone Miner Res 14:1796–1802PubMedCrossRef Duan Y, Parfitt AM, Seeman E (1999) Vertebral bone mass, size, and volumetric density in women with spinal fractures. J Bone Miner Res 14:1796–1802PubMedCrossRef
22.
go back to reference Genant HK, Wu CY, Van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137–1148PubMed Genant HK, Wu CY, Van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137–1148PubMed
23.
go back to reference Genant HK, Delmas PD, Chen P, Jiang Y, Eriksen EF, Dalsky GP, Marcus R, San Martin J (2007) Severity of vertebral fracture reflects deterioration of bone microarchitecture. Osteoporos Int 1:69–76CrossRef Genant HK, Delmas PD, Chen P, Jiang Y, Eriksen EF, Dalsky GP, Marcus R, San Martin J (2007) Severity of vertebral fracture reflects deterioration of bone microarchitecture. Osteoporos Int 1:69–76CrossRef
24.
go back to reference Melton lJ, Lane AW, Cooper C, Eastell R, O’Fallon WM, Riggs BL (1993) Prevalence and incidence of vertebral deformities. Osteoporos Int 3:113–119PubMedCrossRef Melton lJ, Lane AW, Cooper C, Eastell R, O’Fallon WM, Riggs BL (1993) Prevalence and incidence of vertebral deformities. Osteoporos Int 3:113–119PubMedCrossRef
25.
go back to reference Ferrar L, Jiang G, Clowes JA, Peel NF, Eastell R (2008) Comparison of densitometric and radiographic vertebral fracture assessment using the algorithm-based qualitative (ABQ) method in postmenopausal women at low and high risk of fracture. J Bone Miner Res 23:103–111PubMedCrossRef Ferrar L, Jiang G, Clowes JA, Peel NF, Eastell R (2008) Comparison of densitometric and radiographic vertebral fracture assessment using the algorithm-based qualitative (ABQ) method in postmenopausal women at low and high risk of fracture. J Bone Miner Res 23:103–111PubMedCrossRef
26.
go back to reference Binkley N, Bilezikian JP, Kendler DL, Leib ES, Lewiecki EM, Petak SM (2007) Summary of the International Society for Clinical Densitometry 2005 Position Development Conference. J Bone Miner Res 22:643–645PubMedCrossRef Binkley N, Bilezikian JP, Kendler DL, Leib ES, Lewiecki EM, Petak SM (2007) Summary of the International Society for Clinical Densitometry 2005 Position Development Conference. J Bone Miner Res 22:643–645PubMedCrossRef
27.
go back to reference Garnero P (2000) Markers of bone turnover for the prediction of fracture risk. Osteoporos Int 11(Suppl 6):S55–S65PubMedCrossRef Garnero P (2000) Markers of bone turnover for the prediction of fracture risk. Osteoporos Int 11(Suppl 6):S55–S65PubMedCrossRef
28.
go back to reference Bauer DC, Garnero P, Hochberg MC, Santora A, Delmas P, Ewing SK (2006) Pretreatment levels of bone turnover and the antifracture efficacy of alendronate: the fracture intervention trial. J Bone Miner Res 21:292–299PubMedCrossRef Bauer DC, Garnero P, Hochberg MC, Santora A, Delmas P, Ewing SK (2006) Pretreatment levels of bone turnover and the antifracture efficacy of alendronate: the fracture intervention trial. J Bone Miner Res 21:292–299PubMedCrossRef
29.
go back to reference Melton LJ, Crowson CS, O’Fallon WM, Wahner HW, Riggs BL (2003) Relative contributions to bone density, bone turnover, and clinical risk factors to long-term fracture prediction. J Bone Miner Res 18:312–318PubMedCrossRef Melton LJ, Crowson CS, O’Fallon WM, Wahner HW, Riggs BL (2003) Relative contributions to bone density, bone turnover, and clinical risk factors to long-term fracture prediction. J Bone Miner Res 18:312–318PubMedCrossRef
30.
go back to reference Nordin BEC (2003) Should the treatment of osteoporosis be more selective? Osteoporos Int 14:99–102PubMed Nordin BEC (2003) Should the treatment of osteoporosis be more selective? Osteoporos Int 14:99–102PubMed
Metadata
Title
Redefining Osteoporosis
Author
B. E. Christopher Nordin
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Calcified Tissue International / Issue 6/2008
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-008-9186-6

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