Skip to main content
Top
Published in: BMC Nephrology 1/2014

Open Access 01-12-2014 | Research article

Red blood cell (RBC) transfusion rates among US chronic dialysis patients during changes to Medicare end-stage renal disease (ESRD) reimbursement systems and erythropoiesis stimulating agent (ESA) labels

Authors: Katherine A Cappell, Sanatan Shreay, Zhun Cao, Helen V Varker, Carly J Paoli, Matthew Gitlin

Published in: BMC Nephrology | Issue 1/2014

Login to get access

Abstract

Background

Several major ESRD-related regulatory and reimbursement changes were introduced in the United States in 2011. In several large, national datasets, these changes have been associated with decreases in erythropoiesis stimulating agent (ESA) utilization and hemoglobin concentrations in the ESRD population, as well as an increase in the use of red blood cell (RBC) transfusions in this population. Our objective was to examine the use of RBC transfusion before and after the regulatory and reimbursement changes implemented in 2011 in a prevalent population of chronic dialysis patients in a large national claims database.

Methods

Patients in the Truven Health MarketScan Commercial and Medicare Databases with evidence of chronic dialysis were selected for the study. The proportion of chronic dialysis patients who received any RBC transfusion and RBC transfusion event rates per 100 patient-months were calculated in each month from January 1, 2007 to March 31, 2012. The results were analyzed overall and stratified by primary health insurance payer (commercial payer or Medicare).

Results

Overall, the percent of chronic dialysis patients with RBC transfusion and RBC transfusion event rates per 100 patient-months increased between January 2007 and March 2012. When stratified by primary health insurance payer, it appears that the increase was driven by the primary Medicare insurance population. While the percent of patients with RBC transfusion and RBC transfusion event rates did not increase in the commercially insured population between 2007 and 2012 they did increase in the primary Medicare insurance population; the majority of the increase occurred in 2011 during the same time frame as the ESRD-related regulatory and reimbursement changes.

Conclusions

The regulatory and reimbursement changes implemented in 2011 may have contributed to an increase in the use of RBC transfusions in chronic dialysis patients in the MarketScan dataset who were covered by Medicare plus Medicare supplemental insurance.
Appendix
Available only for authorised users
Literature
1.
go back to reference US Renal Data System: USRDS 2012 Annual Data Report. 2012, Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases US Renal Data System: USRDS 2012 Annual Data Report. 2012, Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
2.
3.
go back to reference Adamson JW, Eschbach JW: Erythropoietin for end-stage renal disease. N Engl J Med. 1998, 339: 625-627.CrossRefPubMed Adamson JW, Eschbach JW: Erythropoietin for end-stage renal disease. N Engl J Med. 1998, 339: 625-627.CrossRefPubMed
4.
go back to reference KDOQI: Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis. 2006, 47 (5 Suppl 3): S11-S145. KDOQI: Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis. 2006, 47 (5 Suppl 3): S11-S145.
5.
6.
go back to reference US Renal Data System: USRDS 2010 Annual Data Report. 2010, Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases US Renal Data System: USRDS 2010 Annual Data Report. 2010, Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
7.
go back to reference Amgen Inc: Epogen (epoetin alfa) U.S. package insert, July 2012. 2012, Thousand Oaks, CA: Amgen Inc: Epogen (epoetin alfa) [package insert] Amgen Inc: Epogen (epoetin alfa) U.S. package insert, July 2012. 2012, Thousand Oaks, CA: Amgen Inc: Epogen (epoetin alfa) [package insert]
8.
go back to reference Ibrahim HN, Ishani A, Foley RN, Guo H, Liu J, Collins AJ: Temporal trends in red blood transfusion among US dialysis patients, 1992–2005. Am J Kidney Dis. 2008, 52: 1115-1121.CrossRefPubMed Ibrahim HN, Ishani A, Foley RN, Guo H, Liu J, Collins AJ: Temporal trends in red blood transfusion among US dialysis patients, 1992–2005. Am J Kidney Dis. 2008, 52: 1115-1121.CrossRefPubMed
9.
go back to reference Drueke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU, Scherhag A: CREATE Investigators: Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med. 2006, 355: 2071-2084.CrossRefPubMed Drueke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU, Scherhag A: CREATE Investigators: Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med. 2006, 355: 2071-2084.CrossRefPubMed
10.
go back to reference Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D: CHOIR Investigators: Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006, 355: 2085-2098.CrossRefPubMed Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D: CHOIR Investigators: Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006, 355: 2085-2098.CrossRefPubMed
11.
go back to reference Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R, The TREAT Investigators: A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med October. 2009, 361: 2019-2032.CrossRef Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R, The TREAT Investigators: A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med October. 2009, 361: 2019-2032.CrossRef
16.
go back to reference Amgen Inc: Aranesp (darbepoetin alfa) U.S. package insert, July 2012. 2012, Thousand Oaks, CA: Amgen Inc: Aranesp (darbepoetin alfa) [package insert] Amgen Inc: Aranesp (darbepoetin alfa) U.S. package insert, July 2012. 2012, Thousand Oaks, CA: Amgen Inc: Aranesp (darbepoetin alfa) [package insert]
17.
go back to reference The DOPPS Practice Monitor: Latest update on trends in US hemodialysis practice following policy changes. 2013, Ann Arbor, MI, USA: Arbor Research Collaborative for Health The DOPPS Practice Monitor: Latest update on trends in US hemodialysis practice following policy changes. 2013, Ann Arbor, MI, USA: Arbor Research Collaborative for Health
18.
go back to reference Brunelli SM, Monda KL, Burkart JM, Gitlin M, Neumann PJ, Park GS, Symonian-Silver M, Yue S, Bradbury BD, Rubin RJ: Early trends from the study to evaluate the prospective payment system impact on small dialysis organizations (STEPPS). Am J Kidney Dis. 2013, 61: 947-956.CrossRefPubMed Brunelli SM, Monda KL, Burkart JM, Gitlin M, Neumann PJ, Park GS, Symonian-Silver M, Yue S, Bradbury BD, Rubin RJ: Early trends from the study to evaluate the prospective payment system impact on small dialysis organizations (STEPPS). Am J Kidney Dis. 2013, 61: 947-956.CrossRefPubMed
20.
go back to reference Fuller DS, Pisoni RL, Bieber BA, Gillespie BW, Robinson BM: The DOPPS Practice Monitor for US dialysis care: Trends through December 2011. Am J Kidney Dis. 2013, 61: 342-348.CrossRefPubMed Fuller DS, Pisoni RL, Bieber BA, Gillespie BW, Robinson BM: The DOPPS Practice Monitor for US dialysis care: Trends through December 2011. Am J Kidney Dis. 2013, 61: 342-348.CrossRefPubMed
21.
go back to reference Gitlin M, Lee JA, Spiegel DM, Carson JL, Song X, Custer BS, Cao Z, Cappell KA, Varker HV, Wan S, Ashfaq A: Outpatient red blood cell transfusion payments among patients on chronic dialysis. BMC Nephrology. 2012, 13: 145-CrossRefPubMedPubMedCentral Gitlin M, Lee JA, Spiegel DM, Carson JL, Song X, Custer BS, Cao Z, Cappell KA, Varker HV, Wan S, Ashfaq A: Outpatient red blood cell transfusion payments among patients on chronic dialysis. BMC Nephrology. 2012, 13: 145-CrossRefPubMedPubMedCentral
22.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chron Dis. 1987, 40: 373-383.CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chron Dis. 1987, 40: 373-383.CrossRefPubMed
23.
go back to reference Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992, 45: 613-619.CrossRefPubMed Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992, 45: 613-619.CrossRefPubMed
25.
go back to reference Dodd RY, Notari EP, Stramer SL: Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population. Transfusion. 2002, 42: 975-979.CrossRefPubMed Dodd RY, Notari EP, Stramer SL: Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population. Transfusion. 2002, 42: 975-979.CrossRefPubMed
26.
go back to reference Despotis GJ, Zhang L, Lublin DM: Transfusion risks and transfusion-related pro-inflammatory responses. Hematol Oncol Clin North Am. 2007, 21: 147-161.CrossRefPubMed Despotis GJ, Zhang L, Lublin DM: Transfusion risks and transfusion-related pro-inflammatory responses. Hematol Oncol Clin North Am. 2007, 21: 147-161.CrossRefPubMed
27.
go back to reference Eder AF, Chambers LA: Noninfectious complications of blood transfusion. Arch Pathol Lab Med. 2007, 131: 708-718.PubMed Eder AF, Chambers LA: Noninfectious complications of blood transfusion. Arch Pathol Lab Med. 2007, 131: 708-718.PubMed
29.
go back to reference Obrador GT, Macdougall IC: Effect of red cell transfusions on future kidney transplantation. Clin J Am Soc Nephrol. 2013, 8: 852-860.CrossRefPubMed Obrador GT, Macdougall IC: Effect of red cell transfusions on future kidney transplantation. Clin J Am Soc Nephrol. 2013, 8: 852-860.CrossRefPubMed
Metadata
Title
Red blood cell (RBC) transfusion rates among US chronic dialysis patients during changes to Medicare end-stage renal disease (ESRD) reimbursement systems and erythropoiesis stimulating agent (ESA) labels
Authors
Katherine A Cappell
Sanatan Shreay
Zhun Cao
Helen V Varker
Carly J Paoli
Matthew Gitlin
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2014
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/1471-2369-15-116

Other articles of this Issue 1/2014

BMC Nephrology 1/2014 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.