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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 8/2015

01-11-2015 | Astute Clinician Report

Recurrent Respiratory Infections Revealing CD8α Deficiency

Authors: Erwan Dumontet, Jennifer Osman, Nathalie Guillemont-Lambert, Guilhem Cros, Despina Moshous, Capucine Picard

Published in: Journal of Clinical Immunology | Issue 8/2015

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Abstract

CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes associated with CD8 deficiency.
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Metadata
Title
Recurrent Respiratory Infections Revealing CD8α Deficiency
Authors
Erwan Dumontet
Jennifer Osman
Nathalie Guillemont-Lambert
Guilhem Cros
Despina Moshous
Capucine Picard
Publication date
01-11-2015
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 8/2015
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-015-0213-x

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