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Published in: BMC Surgery 1/2022

Open Access 01-12-2022 | Rectal Cancer | Research article

Available prediction scores of conversion for laparoscopic rectal cancer surgery seem to be unsuitable for nowadays rectal cancer management

Authors: Hamza Sekkat, Amine Souadka, Lise Courtot, Ali Rafik, Laila Amrani, Amine Benkabbou, Pierre Peyrafort, Urs Giger-Pabst, Elias Karam, Raouf Mohsine, Anass M. Majbar, Mehdi Ouaissi

Published in: BMC Surgery | Issue 1/2022

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Abstract

Introduction

This study aimed to externally evaluate the accuracy of four predictive scores for conversion to open surgery after rectal laparoscopic resection. None of the four scores achieved external validation previously.

Methods

This was a retrospective analysis of two prospectively maintained databases from two academic centers in France and Morocco. All consecutive patients who underwent laparoscopic resection for rectal adenocarcinoma between 2005 and 2020 were included. Logistic regression was used to assess the association between the factors present in the four scores and conversion. The accuracy of each score was assessed using the area under the curve (AUC). Observed and predicted conversion rates were compared for each score using the Chi-square goodness-of-fit test.

Results

Four hundred patients were included. There were 264 men (66%) with a mean age of 65.95 years (standard deviation 12.2). The median tumor height was 7 cm (quartiles 4–11) and 29% of patients had low rectal tumors. Conversion rate was 21.75%. The accuracy to predict conversion was low with an AUC lower than 0,62 for the four models. The observed conversion rates were significantly different from the predicted rates, except for one score.

Conclusions

The four models had low accuracy in predicting the conversion to open surgery for laparoscopic rectal resection. There is a need for new well-designed studies, analyzing more specific variables, in a multicentric design to ensure generalizability of the results for daily surgical practice.
Literature
1.
go back to reference Greenblatt DY, Rajamanickam V, Pugely AJ, Heise CP, Foley EF, Kennedy GD. Short-term outcomes after laparoscopic-assisted proctectomy for rectal cancer: results from the ACS NSQIP. J Am Coll Surg. 2011;212:844–54.CrossRef Greenblatt DY, Rajamanickam V, Pugely AJ, Heise CP, Foley EF, Kennedy GD. Short-term outcomes after laparoscopic-assisted proctectomy for rectal cancer: results from the ACS NSQIP. J Am Coll Surg. 2011;212:844–54.CrossRef
2.
go back to reference Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AMH, Heath RM, Brown JM, MRC CLASICC trial group. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365:1718–26.CrossRef Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AMH, Heath RM, Brown JM, MRC CLASICC trial group. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365:1718–26.CrossRef
3.
go back to reference van der Pas MH, Haglind E, Cuesta MA, Fürst A, Lacy AM, Hop WC, Bonjer HJ, COlorectal cancer Laparoscopic or Open Resection II (COLOR II) Study Group. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol. 2013;14:210–8.CrossRef van der Pas MH, Haglind E, Cuesta MA, Fürst A, Lacy AM, Hop WC, Bonjer HJ, COlorectal cancer Laparoscopic or Open Resection II (COLOR II) Study Group. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol. 2013;14:210–8.CrossRef
4.
go back to reference Kayano H, Okuda J, Tanaka K, Kondo K, Tanigawa N. Evaluation of the learning curve in laparoscopic low anterior resection for rectal cancer. Surg Endosc. 2011;25:2972–9.CrossRef Kayano H, Okuda J, Tanaka K, Kondo K, Tanigawa N. Evaluation of the learning curve in laparoscopic low anterior resection for rectal cancer. Surg Endosc. 2011;25:2972–9.CrossRef
5.
go back to reference Agha A, Fürst A, Iesalnieks I, Fichtner-Feigl S, Ghali N, Krenz D, Anthuber M, Jauch KW, Piso P, Schlitt HJ. Conversion rate in 300 laparoscopic rectal resections and its influence on morbidity and oncological outcome. Int J Colorectal Dis. 2008;23:409–17.CrossRef Agha A, Fürst A, Iesalnieks I, Fichtner-Feigl S, Ghali N, Krenz D, Anthuber M, Jauch KW, Piso P, Schlitt HJ. Conversion rate in 300 laparoscopic rectal resections and its influence on morbidity and oncological outcome. Int J Colorectal Dis. 2008;23:409–17.CrossRef
6.
go back to reference Vaccaro CA, Rossi GL, Quintana GO, Soriano ER, Vaccarezza H, Rubinstein F. Laparoscopic colorectal resections: a simple predictor model and a stratification risk for conversion to open surgery. Dis Colon Rectum. 2014;57:869–74.CrossRef Vaccaro CA, Rossi GL, Quintana GO, Soriano ER, Vaccarezza H, Rubinstein F. Laparoscopic colorectal resections: a simple predictor model and a stratification risk for conversion to open surgery. Dis Colon Rectum. 2014;57:869–74.CrossRef
7.
go back to reference Zhang G-D, Zhi X-T, Zhang J-L, Bu G-B, Ma G, Wang K-L. Preoperative prediction of conversion from laparoscopic rectal resection to open surgery: a clinical study of conversion scoring of laparoscopic rectal resection to open surgery. Int J Colorectal Dis. 2015;30:1209–16.CrossRef Zhang G-D, Zhi X-T, Zhang J-L, Bu G-B, Ma G, Wang K-L. Preoperative prediction of conversion from laparoscopic rectal resection to open surgery: a clinical study of conversion scoring of laparoscopic rectal resection to open surgery. Int J Colorectal Dis. 2015;30:1209–16.CrossRef
8.
go back to reference Tekkis PP, Senagore AJ, Delaney CP. Conversion rates in laparoscopic colorectal surgery: a predictive model with 1253 patients. Surg Endosc. 2005;19:47–54.CrossRef Tekkis PP, Senagore AJ, Delaney CP. Conversion rates in laparoscopic colorectal surgery: a predictive model with 1253 patients. Surg Endosc. 2005;19:47–54.CrossRef
9.
go back to reference Schlachta CM, Mamazza J, Seshadri PA, Cadeddu MO, Poulin EC. Predicting conversion to open surgery in laparoscopic colorectal resections. A simple clinical model. Surg Endosc. 2000;14:1114–7.CrossRef Schlachta CM, Mamazza J, Seshadri PA, Cadeddu MO, Poulin EC. Predicting conversion to open surgery in laparoscopic colorectal resections. A simple clinical model. Surg Endosc. 2000;14:1114–7.CrossRef
10.
go back to reference Ebrahim S, Clarke M. STROBE: new standards for reporting observational epidemiology, a chance to improve. Int J Epidemiol. 2007;36:946–8.CrossRef Ebrahim S, Clarke M. STROBE: new standards for reporting observational epidemiology, a chance to improve. Int J Epidemiol. 2007;36:946–8.CrossRef
11.
go back to reference Gérard J-P, André T, Bibeau F, Conroy T, Legoux J-L, Portier G, Bosset J-F, Cadiot G, Bouché O, Bedenne L, Française S, de Chirurgie Digestive (SFCD), Société Française d’Endoscopie Digestive (SFED), Société Française de Radiothérapie Oncologique (SFRO). Rectal cancer: French Intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO). Dig Liver Dis. 2017;49:359–67.CrossRef Gérard J-P, André T, Bibeau F, Conroy T, Legoux J-L, Portier G, Bosset J-F, Cadiot G, Bouché O, Bedenne L, Française S, de Chirurgie Digestive (SFCD), Société Française d’Endoscopie Digestive (SFED), Société Française de Radiothérapie Oncologique (SFRO). Rectal cancer: French Intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO). Dig Liver Dis. 2017;49:359–67.CrossRef
12.
go back to reference Fleshman J, Sargent DJ, Green E, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W, Nelson H, Clinical Outcomes of Surgical Therapy Study Group. Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial. Ann Surg. 2007;246:655–62; discussion 662-4.CrossRef Fleshman J, Sargent DJ, Green E, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W, Nelson H, Clinical Outcomes of Surgical Therapy Study Group. Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial. Ann Surg. 2007;246:655–62; discussion 662-4.CrossRef
13.
go back to reference Cima RR, Hassan I, Poola VP, Larson DW, Dozois EJ, Larson DR, O’Byrne MM, Huebner M. Failure of institutionally derived predictive models of conversion in laparoscopic colorectal surgery to predict conversion outcomes in an independent data set of 998 laparoscopic colorectal procedures. Ann Surg. 2010;251:652–8.CrossRef Cima RR, Hassan I, Poola VP, Larson DW, Dozois EJ, Larson DR, O’Byrne MM, Huebner M. Failure of institutionally derived predictive models of conversion in laparoscopic colorectal surgery to predict conversion outcomes in an independent data set of 998 laparoscopic colorectal procedures. Ann Surg. 2010;251:652–8.CrossRef
14.
go back to reference Hosmer DW, Lemeshow S, Sturdivant RX (2013) Applied logistic regression. Wiley Series in Probability and Statistics. Hosmer DW, Lemeshow S, Sturdivant RX (2013) Applied logistic regression. Wiley Series in Probability and Statistics.
15.
go back to reference Schwandner O, Schiedeck TH, Bruch H. The role of conversion in laparoscopic colorectal surgery: do predictive factors exist? Surg Endosc. 1999;13:151–6.CrossRef Schwandner O, Schiedeck TH, Bruch H. The role of conversion in laparoscopic colorectal surgery: do predictive factors exist? Surg Endosc. 1999;13:151–6.CrossRef
16.
go back to reference Crippa J, Grass F, Achilli P, Mathis KL, Kelley SR, Merchea A, Colibaseanu DT, Larson DW. Risk factors for conversion in laparoscopic and robotic rectal cancer surgery. Br J Surg. 2020;107:560–6.CrossRef Crippa J, Grass F, Achilli P, Mathis KL, Kelley SR, Merchea A, Colibaseanu DT, Larson DW. Risk factors for conversion in laparoscopic and robotic rectal cancer surgery. Br J Surg. 2020;107:560–6.CrossRef
17.
go back to reference Jayne D, Pigazzi A, Marshall H, Croft J, Corrigan N, Copeland J, Quirke P, West N, Rautio T, Thomassen N, Tilney H, Gudgeon M, Bianchi PP, Edlin R, Hulme C, Brown J. Effect of robotic-assisted vs conventional laparoscopic surgery on risk of conversion to open laparotomy among patients undergoing resection for rectal cancer: the ROLARR randomized clinical trial. JAMA. 2017;318:1569–80.CrossRef Jayne D, Pigazzi A, Marshall H, Croft J, Corrigan N, Copeland J, Quirke P, West N, Rautio T, Thomassen N, Tilney H, Gudgeon M, Bianchi PP, Edlin R, Hulme C, Brown J. Effect of robotic-assisted vs conventional laparoscopic surgery on risk of conversion to open laparotomy among patients undergoing resection for rectal cancer: the ROLARR randomized clinical trial. JAMA. 2017;318:1569–80.CrossRef
18.
go back to reference Franko J, O’Connell BG, Mehall JR, Harper SG, Nejman JH, Zebley DM, Fassler SA. The influence of prior abdominal operations on conversion and complication rates in laparoscopic colorectal surgery. JSLS. 2006;10:169–75.PubMedPubMedCentral Franko J, O’Connell BG, Mehall JR, Harper SG, Nejman JH, Zebley DM, Fassler SA. The influence of prior abdominal operations on conversion and complication rates in laparoscopic colorectal surgery. JSLS. 2006;10:169–75.PubMedPubMedCentral
19.
go back to reference van der Pas MHGM, Deijen CL, Abis GSA, de Lange-de Klerk ESM, Haglind E, Fürst A, Lacy AM, Cuesta MA, Bonjer HJ, COLOR II study group. Conversions in laparoscopic surgery for rectal cancer. Surg Endosc. 2017;31:2263–70.CrossRef van der Pas MHGM, Deijen CL, Abis GSA, de Lange-de Klerk ESM, Haglind E, Fürst A, Lacy AM, Cuesta MA, Bonjer HJ, COLOR II study group. Conversions in laparoscopic surgery for rectal cancer. Surg Endosc. 2017;31:2263–70.CrossRef
20.
go back to reference Atasoy G, Arslan NC, Elibol FD, Sagol O, Obuz F, Sokmen S. Magnetic resonance-based pelvimetry and tumor volumetry can predict surgical difficulty and oncologic outcome in locally advanced mid-low rectal cancer. Surg Today. 2018;48:1040–51.CrossRef Atasoy G, Arslan NC, Elibol FD, Sagol O, Obuz F, Sokmen S. Magnetic resonance-based pelvimetry and tumor volumetry can predict surgical difficulty and oncologic outcome in locally advanced mid-low rectal cancer. Surg Today. 2018;48:1040–51.CrossRef
21.
go back to reference Yamamoto T, Kawada K, Kiyasu Y, Itatani Y, Mizuno R, Hida K, Sakai Y. Prediction of surgical difficulty in minimally invasive surgery for rectal cancer by use of MRI pelvimetry. BJS Open. 2020;4:666–77.CrossRef Yamamoto T, Kawada K, Kiyasu Y, Itatani Y, Mizuno R, Hida K, Sakai Y. Prediction of surgical difficulty in minimally invasive surgery for rectal cancer by use of MRI pelvimetry. BJS Open. 2020;4:666–77.CrossRef
22.
go back to reference Kim JY, Kim YW, Kim NK, Hur H, Lee K, Min BS, Cho HJ. Pelvic anatomy as a factor in laparoscopic rectal surgery: a prospective study. Surg Laparosc Endosc Percutan Tech. 2011;21:334–9.CrossRef Kim JY, Kim YW, Kim NK, Hur H, Lee K, Min BS, Cho HJ. Pelvic anatomy as a factor in laparoscopic rectal surgery: a prospective study. Surg Laparosc Endosc Percutan Tech. 2011;21:334–9.CrossRef
23.
go back to reference Ackerman SJ, Daniel S, Baik R, Liu E, Mehendale S, Tackett S, Hellan M. Comparison of complication and conversion rates between robotic-assisted and laparoscopic rectal resection for rectal cancer: which patients and providers could benefit most from robotic-assisted surgery? J Med Econ. 2018;21:254–61.CrossRef Ackerman SJ, Daniel S, Baik R, Liu E, Mehendale S, Tackett S, Hellan M. Comparison of complication and conversion rates between robotic-assisted and laparoscopic rectal resection for rectal cancer: which patients and providers could benefit most from robotic-assisted surgery? J Med Econ. 2018;21:254–61.CrossRef
Metadata
Title
Available prediction scores of conversion for laparoscopic rectal cancer surgery seem to be unsuitable for nowadays rectal cancer management
Authors
Hamza Sekkat
Amine Souadka
Lise Courtot
Ali Rafik
Laila Amrani
Amine Benkabbou
Pierre Peyrafort
Urs Giger-Pabst
Elias Karam
Raouf Mohsine
Anass M. Majbar
Mehdi Ouaissi
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2022
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-022-01617-9

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