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Current Rheumatology Reports
Published in: Current Rheumatology Reports 6/2011

01-12-2011 | Rheumatic Manifestations of Other Diseases (Roland Staud, Section Editor)

Recent Advances in the Understanding of Genetic Susceptibility to Chronic Pain and Somatic Symptoms

Authors: Kate L. Holliday, John McBeth

Published in: Current Rheumatology Reports | Issue 6/2011

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Abstract

Regional (e.g., low back) and widespread chronic pain disorders are common in the general population and are known to be heritable. Recent research suggests that genetic factors increase the risk of developing chronic pain independent of the site of pain. Candidate gene studies have been conducted on key pathways to elucidate susceptibility genes that are likely to be involved in both the sensory and affective components of pain. Findings have been largely equivocal, predominantly due to small sample size, but larger studies of pain in general population samples are being conducted. Interesting candidate genes from animal models and monogenic pain disorders are beginning to emerge. Recent advances in genetics research have yet to make an impact in the pain field but provide considerable scope for future research efforts.
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Metadata
Title
Recent Advances in the Understanding of Genetic Susceptibility to Chronic Pain and Somatic Symptoms
Authors
Kate L. Holliday
John McBeth
Publication date
01-12-2011
Publisher
Current Science Inc.
Published in
Current Rheumatology Reports / Issue 6/2011
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-011-0208-4

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