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Alzheimer's Research & Therapy
Published in: Alzheimer's Research & Therapy 1/2018

Open Access 01-12-2018 | Research

Reactions to learning a “not elevated” amyloid PET result in a preclinical Alzheimer’s disease trial

Authors: Joshua D. Grill, Chelsea G. Cox, Kristin Harkins, Jason Karlawish

Published in: Alzheimer's Research & Therapy | Issue 1/2018

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Abstract

Background

The experiences of biomarker-ineligible cognitively normal persons can inform trial conduct and the translation of preclinical Alzheimer’s disease (AD) into clinical practice.

Methods

We interviewed 33 persons whose “not elevated” brain amyloid imaging biomarker result made them ineligible for a preclinical AD trial.

Results

Most participants (n = 17) reported being informed that they did not demonstrate adequately elevated amyloid to qualify, whereas some (n = 14) reported being told they had no amyloid or plaques. Relief (n = 17) and disappointment related to not being able to participate (n = 12) were the most common reactions to results. Nearly all participants would have made healthy lifestyle changes if they had received an “elevated” result, would have another scan, and would participate in another AD prevention trial.

Conclusions

Although some participants may misconstrue results, disclosure of a “not elevated” amyloid result in the research setting causes little behavior change; willingness to participate in AD research remains.
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Metadata
Title
Reactions to learning a “not elevated” amyloid PET result in a preclinical Alzheimer’s disease trial
Authors
Joshua D. Grill
Chelsea G. Cox
Kristin Harkins
Jason Karlawish
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Alzheimer's Research & Therapy / Issue 1/2018
Electronic ISSN: 1758-9193
DOI
https://doi.org/10.1186/s13195-018-0452-1

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