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World Journal of Pediatrics
Published in: World Journal of Pediatrics 6/2020

01-12-2020 | Ranitidine | Personal Viewpoint

Say no to drugs: wait and watch strategy for medications used in the neonatal intensive care unit (NICU)

Authors: Hilary Tice, Shabih Manzar, Nitin Walyat, Kelsey Trimble

Published in: World Journal of Pediatrics | Issue 6/2020

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Excerpt

From the presentation of gray baby syndrome with chloramphenicol use to gasping baby syndrome with exposure from benzyl alcohol in bacteriostatic flushes, historical clinical precedence has shown that babies cared for in the neonatal intensive care unit (NICU) are at higher risk of adverse effects from medication administration than other populations [1, 2]. Historical precedence led to a discussion amongst the multi-disciplinary team questioning whether medications are used excessively in the NICU. A recent review paper by Hsieh et al. [3] has elaborated on this question in detail, in which a downward trend in the use of certain medications was shown. …
Literature
1.
Wax PM. Toxicologic misfortunes and catastrophes in history. In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldrank LR, Hoffman RS, editors. Goldfrank’s toxicologic emergencies [Internet]. 11th ed. China: McGraw-Hill; 2019.
2.
3.
Hsieh EM, Hornik CP, Clark RH, Laughon MM, Benjamin DK, Smith PB, et al. Medication use in the neonatal intensive care unit. Am J Perinatol. 2014;31:811–21.PubMed
4.
Krzyzaniak N, Bajorek B. Medication safety in neonatal care: a review of medication errors among neonates. Ther Adv Drug Saf. 2016;7:102–19.PubMedPubMedCentral
5.
Barr J, Brenner-Zada G, Heiman E, Pareth G, Bulkowstein M, Greenberg R, et al. Unlicensed and off-label medication use in a neonatal intensive care unit: a prospective study. Am J Perinatol. 2002;19:67–72.PubMed
6.
Conroy S, McIntyre J. The use of unlicensed and off-label medicines in the neonate. Semin Fetal Neonatal Med. 2005;10:115–22.PubMed
7.
Ryan G, Dooley J, Gerber Finn L, Kelly L. Nonpharmacological management of neonatal abstinence syndrome: a review of the literature. J Matern Fetal Neonatal Med. 2019;32:1735–40.PubMed
8.
Terrin G, Passariello A, De Curtis M, Manguso F, Salvia G, Lega L, et al. Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns. Pediatrics. 2012;129:e40–5.PubMed
9.
Santana RNS, Santos VS, Ribeiro-Júnior RF, Freire MS, Menezes MAS, Cipolotti R, et al. Use of ranitidine is associated with infections in newborns hospitalized in a neonatal intensive care unit: a cohort study. BMC Infect Dis. 2017;17:375.PubMedPubMedCentral
10.
Eras Z, Oguz SS, Dilmen U. Is metoclopramide safe for the premature infant? Eur Rev Med Pharmacol Sci. 2013;17:1655–7.PubMed
11.
Clark RH, Bloom BT, Spitzer AR, Gerstmann DR. Empiric use of ampicillin and cefotaxime, compared with ampicillin and gentamicin, for neonates at risk for sepsis is associated with an increased risk of neonatal death. Pediatrics. 2006;117:67–74.PubMed
12.
Schwartz E, Zelig R, Parker A, Johnson S. Vitamin A supplementation for the prevention of bronchopulmonary dysplasia in preterm infants: an update. Nutr Clin Pract. 2017;32:346–53.PubMed
13.
Couroucli XI, Placencia JL, Cates LA, Suresh GK. Should we still use vitamin A to prevent bronchopulmonary dysplasia? J Perinatol. 2016;36:581.PubMed
14.
Garg BD, Bansal A, Kabra NS. Role of vitamin A supplementation in prevention of bronchopulmoary diysplasia in extremely low birth weight neonates: a systematic review of randomized trials. J Matern Fetal Neonatal Med. 2019;32:2608–15.PubMed
15.
Halliday HL. Update on postnatal steroids. Neonatology. 2017;111:415–22.PubMed
16.
Rabi Y, Singhal N, Nettel-Aguirre A. Room-air versus oxygen administration for resuscitation of preterm infants: the ROAR study. Pediatrics. 2011;128:e374–81.PubMed
Metadata
Title
Say no to drugs: wait and watch strategy for medications used in the neonatal intensive care unit (NICU)
Authors
Hilary Tice
Shabih Manzar
Nitin Walyat
Kelsey Trimble
Publication date
01-12-2020
Publisher
Springer Singapore
Published in
World Journal of Pediatrics / Issue 6/2020
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-019-00323-6

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