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International Ophthalmology

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01-12-2024 | Ranibizumab | Original Paper

Changes in ocular blood flow in patients with neovascular age-related macular degeneration after intravitreal injection of ranibizumab biosimilar and brolucizumab

Authors: Hiroki Takizawa, Masayuki Yasuda, Keisuke Hoshi, Tatsu Okabe, Hiroshi Kunikata, Toru Nakazawa

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

To assess ocular blood flow (OBF) changes in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal injections of ranibizumab biosimilar (IVRbs) or brolucizumab (IVBr).

Methods

This retrospective longitudinal study included 43 eyes of 43 patients (74.5 ± 9.8 years old, male to female ratio 31:12) with nAMD treated with IVBr (29 eyes) or IVRbs (14 eyes). OBF in the optic nerve head (ONH) and choroid (Ch) was measured with laser speckle flowgraphy (Softcare Co., Ltd., Fukutsu, Japan) before and one month after treatment. Changes in mean blur rate (MBR) before and after each treatment were tested using Wilcoxon’s signed-rank tests and mixed-effect models for repeated measures.

Results

In the IVBr group, MBR was significantly reduced in both the ONH and Ch (p < 0.01). In contrast, the IVRbs group showed no significant change in MBR in either the ONH or Ch (p = 0.56, p = 1). The linear mixed effect model showed a significant interaction between time and anti-VEGF drugs for MBR in both the ONH and Ch (ONH: p = 0.04; Ch: p = 0.002). A post hoc pairwise comparison of estimated marginal means showed that MBR decreased significantly only after IVBr (p < 0.001).

Conclusion

Our findings suggest that the short-term impact on OBF varies depending on the drug used for nAMD.

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Title: Changes in ocular blood flow in patients with neovascular age-related macular degeneration after intravitreal injection of ranibizumab biosimilar and brolucizumab
Authors: Hiroki Takizawa
Masayuki Yasuda
Keisuke Hoshi
Tatsu Okabe
Hiroshi Kunikata
Toru Nakazawa
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keywords: Ranibizumab
Macular Degeneration
Laser
Aflibercept
Retinal Diseases
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03107-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Changes in ocular blood flow in patients with neovascular age-related macular degeneration after intravitreal injection of ranibizumab biosimilar and brolucizumab

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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