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Annals of Nuclear Medicine

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01-02-2014 | Original Article

Radius dependence of FP-CIT quantification: a Monte Carlo-based simulation study

Authors: Walter Koch, Peter Bartenstein, Christian la Fougère

Published in: Annals of Nuclear Medicine | Issue 2/2014

Abstract

Objective

Dopamine transporter imaging with SPECT is a valuable tool for both clinical routine and research studies. Semi-quantitative analysis plays a key role in interpreting the scans, but is dependent on numerous factors, rotational radius being one of them. This study systematically evaluates the potential influence of radius of rotation on apparent tracer binding and describes methods for correction.

Methods

Monte Carlo simulation scans of a digital brain phantom with various disease states and various radii of rotation ranging from 13 to 30 cm were analyzed using 4 different methods of semi-quantification. Different volumes of interest as well as a method with partial volume correction were applied.

Results

For conventional 3D semi-quantification methods the decrease of measured striatal binding per cm additional radius rotation lied in the range between 2.5 and 3.1 %, whereas effects were negligible when applying recovery-corrected quantification. Effects were independent of disease state.

Conclusion

Partial volume effects with increasing radius of rotation can lead to considerable decrease of measured binding ratios, particularly when applying dopamine transporter imaging in a research setting. Standardization of acquisition radius can avoid the effect; correction seems feasible, but the correction factors depend on the quantification approach applied.

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Title: Radius dependence of FP-CIT quantification: a Monte Carlo-based simulation study
Authors: Walter Koch
Peter Bartenstein
Christian la Fougère
Publication date: 01-02-2014
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 2/2014
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-013-0789-2

At a glance: The STEP trials

Springer Medicine

Radius dependence of FP-CIT quantification: a Monte Carlo-based simulation study

Abstract

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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