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Clinical Oral Investigations

Published in:

01-06-2020 | Radiotherapy | Review

Taste disorder’s management: a systematic review

Authors: Adeline Braud, Yves Boucher

Published in: Clinical Oral Investigations | Issue 6/2020

Abstract

Background

Taste disorder is a frequent drug-induced or disease-related oral trouble. Various pharmacological, surgical, or physical treatments have previously been proposed for taste function recovery.

Objectives

The aim of the present systematic review was to assess the effects of palliative and curative interventions on taste recovery in light of recent literature.

Materials and methods

In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search of the literature published up to June 2019 was conducted using MEDLINE via PubMed, EMBASE, and The US National Institutes of Health Trials Register (PROSPERO registration reference: CRD 42019139315). The methodological quality of the included trials was rated with the “Delphi list For Quality Assessment of Randomized Clinical Trials” and the Newcastle-Ottawa scale.

Results

From the 1842 titles first identified, 28 articles met the inclusion criteria. Interventions included zinc (aspartate, sulfate, gluconate, acetate, picolinate, and Polaprezinc®), esomeprazole, l-thyroxin, bethanechol, oral glutamine, delta-9-tetrahydrocannabinol, alpha-lipoic acid, Ginkgo biloba, artificial saliva, pilocarpine, local anesthesia, and improved oral hygiene. The quality of evidence ranged from poor to high.

Conclusion

Improving oral hygiene may promote taste ability. Zinc may prevent and alleviate taste disorder in patients undergoing head and neck radiotherapy.

Clinical relevance

The systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects.

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Title: Taste disorder’s management: a systematic review
Authors: Adeline Braud
Yves Boucher
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Radiotherapy
Taste Disorder
Cytostatic Therapy
Published in: Clinical Oral Investigations / Issue 6/2020
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03299-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Taste disorder’s management: a systematic review

Abstract

Background

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

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