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24-11-2023 | Radiotherapy | Original Article

Clinical outcomes and failure patterns after postoperative radiotherapy for oral cavity squamous cell carcinoma

Authors: Saori Tatsuno, Hiroshi Doi, MD, PhD, Masahiro Inada, Takuya Uehara, Yutaro Wada, Kazuki Ishikawa, Kaoru Tanaka, Mutsukazu Kitano, Yasumasa Nishimura

Published in: Strahlentherapie und Onkologie | Issue 5/2024

Abstract

Purpose

This study aimed to assess recurrence patterns and identify the optimal dose and target volumes of postoperative radiotherapy (PORT) in patients with oral cavity squamous cell carcinoma (OSCC).

Methods

Data of 111 patients who received PORT for OSCC between January 2010 and April 2020 were retrospectively reviewed. The median age was 68 years (range 19–88). PORT was administered as initial treatment to 63 patients and as salvage treatment for recurrent tumors to 48 patients. The median prescribed dose was 60 Gy (range 50–66) administered in 30 fractions (range 25–33).

Results

Median follow-up time was 73 months (range 24–147). Overall survival (OS), progression-free survival (PFS), local control (LC), and locoregional control (LRC) at 3 years were 55.6%, 45.6%, 74.6%, and 63.1%, respectively. There were no significant differences in OS, PFS, LC, and LRC between the initially diagnosed and postoperative recurrent cases. Of 22 patients (20%) who developed regional nodal recurrences, 17 (15%) and 11 (10%) had in-field and out-of-field recurrences, respectively. Of 105 patients who received irradiation to the primary tumor bed, 24 (23%) developed recurrence at the primary site. The PFS and LC rates were significantly worse in patients receiving ≤ 56 Gy to the primary site than those receiving > 56 Gy (p = 0.016 and p = 0.032, respectively).

Conclusion

PORT was effective for postoperative recurrences as well as for initially diagnosed oral cavity cancer. Doses greater than 56 Gy to the primary site may be required in PORT for OSCC.

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Title: Clinical outcomes and failure patterns after postoperative radiotherapy for oral cavity squamous cell carcinoma
Authors: Saori Tatsuno
Hiroshi Doi, MD, PhD
Masahiro Inada
Takuya Uehara
Yutaro Wada
Kazuki Ishikawa
Kaoru Tanaka
Mutsukazu Kitano
Yasumasa Nishimura
Publication date: 24-11-2023
Publisher: Springer Berlin Heidelberg
Keywords: Radiotherapy
Neck Dissection
Published in: Strahlentherapie und Onkologie / Issue 5/2024
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-023-02171-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical outcomes and failure patterns after postoperative radiotherapy for oral cavity squamous cell carcinoma

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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