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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2024

Open Access 01-12-2024 | Radiotherapy | Case report

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report

Authors: Daniel Tong, Julia Chisholm, Brendan Madden, Merina Ahmed

Published in: Journal of Medical Case Reports | Issue 1/2024

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Abstract

Background

Pulmonary inflammatory myofibroblastic tumour (IMT) is a rare condition that usually presents in young individuals and is associated with anaplastic lymphoma kinase (ALK)-translocation.

Case presentation

We report a case of an 18-year-old Caucasian man with ALK-translocated pulmonary IMT treated with multimodality therapy. The patient presented with breathlessness and was found to have a collapsed left lung. Further investigations revealed an ALK-translocated pulmonary IMT. This is usually treated with an ALK-inhibitor but patient declined after discussing potential side-effects and had repeated rigid bronchoscopic interventions for local disease control. Due to persistent local recurrence, patient received radical external beam radiotherapy (EBRT) with pulse steroids, and one year later started on Ibuprofen, a non-steroidal anti-inflammatory agent (NSAID). Following multimodality treatment, he developed a complete response. He remains treatment-free for the past seven years. Eleven years on from his diagnosis, he remains in remission with a ECOG performance status of zero.

Conclusions

Achieving long-term local control in pulmonary IMT can be challenging. Multimodality treatment is sometimes needed but the overall outlook remains good.
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Metadata
Title
Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report
Authors
Daniel Tong
Julia Chisholm
Brendan Madden
Merina Ahmed
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2024
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-024-04472-9

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