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BMC Surgery
Published in: BMC Surgery 1/2022

Open Access 01-12-2022 | Radiotherapy | Research article

Survival outcome of local vs. radical excision in rectal gastrointestinal stromal tumor: a SEER database analysis

Authors: Jianchang Wei, Junbin Zhong, Zhuanpeng Chen, Qing Huang, Fang Wei, Qiang Wang, Jie Cao

Published in: BMC Surgery | Issue 1/2022

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Abstract

Background

The choice of surgical strategy for patients with rectal gastrointestinal stromal tumor (GIST) remains controversial. This study aims to address whether the surgical procedure [local excision (LE) vs. radical excision (RE)] influences the survival outcomes.

Methods

The information of the patients recruited in this study was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. A survival curve was used to evaluate the differences in cancer-specific survival (CSS).

Results

No significant difference was detected in the CSS between the LE and RE groups. Also, no significant differences were observed in the CSS between the two groups with respect to different T classification, N classification, tumor differentiation, tumor size, regional LN surgery, age, gender, race, chemotherapy, and radiotherapy. The T classification and age were independent prognostic factors in rectal GIST patients.

Conclusions

LE and RE have similar survival time after surgery, and LE could be considered as an effective surgical approach for rectal GIST.
Literature
1.
Miettinen M, Lasota J. Gastrointestinal stromal tumors. Gastroenterol Clin N Am. 2013;42(2):399–415.CrossRef
2.
Ijzerman NS, et al. Quality of treatment and surgical approach for rectal gastrointestinal stromal tumour (GIST) in a large European cohort. Eur J Surg Oncol. 2020;46(6):1124–30.CrossRef
3.
Corless CL, Ballman KV, Antonescu CR, et al. Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial. J Clin Oncol. 2014;32(15):1563–70.CrossRef
4.
Bischof DA, Kim Y, Dodson R, Jimenez MC, et al. Conditional disease-free survival after surgical resection of gastrointestinal stromal tumors: a multiinstitutional analysis of 502 patients. JAMA Surg. 2015;150(4):299–306.CrossRef
5.
Kaneko M, Emoto S, Murono K, et al. Neoadjuvant imatinib therapy in rectal gastrointestinal stromal tumors. Surg Today. 2019;49:460–6.CrossRef
6.
Guo W, Yang Z, Wei Y, et al. Radical excision versus local resection for primary rectal gastrointestinal stromal tumors. Int J Surg. 2020;77:190–7.CrossRef
7.
Changchien CR, Wu MC, Tasi WS, et al. Evaluation of prognosis for malignant rectal gastrointestinal stromal tumor by clinical parameters and immunohistochemical staining. Dis Colon Rectum. 2004;47(11):1922–9.CrossRef
8.
Gaitanidis A, Lakis M, Alevizakos M, et al. Predictors of lymph node metastasis in patients with gastrointestinal stromal tumors (GISTs). Langenbecks Arch Surg. 2018;403:599–606.CrossRef
9.
Gervaz P, Huber O, Morel P. Surgical management of gastrointestinal stromal tumours. Br J Surg. 2009;96(6):567–78.CrossRef
10.
Wilkinson MJ, Fitzgerald JE, Strauss DC, et al. Surgical treatment of gastrointestinal stromal tumour of the rectum in the era of imatinib. Br J Surg. 2015;102(8):965–71.CrossRef
11.
Cavnar M, Wang L, Balachandran V, et al. Rectal gastrointestinal stromal tumor (GIST) in the era of imatinib organ-preservation and improved oncologic outcome. Ann Surg Oncol. 2017;24(13):3972–80.CrossRef
12.
Jakob J, Mussi C, Ronellenfitsch U, et al. Gastrointestinal stromal tumor of the rectum: results of surgical and multimodality therapy in the era of imatinib. Ann Surg Oncol. 2013;20(2):586–92.CrossRef
13.
Yasui M, Tsujinaka T, Mori M, et al. Characteristics and prognosis of rectal gastrointestinal stromal tumors an analysis of registry data. Surg Today. 2017;47:1188–94.CrossRef
14.
Shu P, Sun XF, Fang Y, et al. Clinical outcomes of different therapeutic modalities for rectal gastrointestinal stromal tumor: summary of 14-year clinical experience in a single center. Int J Surg. 2020;77:1–7.CrossRef
15.
Huynh TK, Meeus P, Cassier P, et al. Primary localized rectal/pararectal gastrointestinal stromal tumors: results of surgical and multimodal therapy from the French Sarcoma group. BMC Cancer. 2014;14:156.1-9.CrossRef
16.
Kameyama H, Kanda T, Tajima Y, et al. Management of rectal gastrointestinal stromal tumor. Transl Gastroenterol Hepatol. 2018;3:8.1-9.CrossRef
17.
Tielen R, Verhoef C, van Coevorden F, et al. Surgical management of rectal gastrointestinal stromal tumors. J Surg Oncol. 2013;107(4):320–3.CrossRef
18.
Shen C, Chen H, Yin R, et al. Clinicopathologic, surgical characteristics and survival outcomes of rectal gastrointestinal stromal tumors. Neoplasma. 2015;62(4):610–7.CrossRef
19.
Han X, Xu J, Qiu H, Lin G. A novel curative treatment strategy for patients with lower grade rectal gastrointestinal stromal tumor: chemoreduction combined with transanal endoscopic microsurgery. J Laparoendosc Adv Surg Tech. 2017;27(6):579–85.CrossRef
20.
Liu Z, Wu S, Gou S, et al. A population-based study of the incidence and survival of anorectal gastrointestinal stromal tumor. Med Sci Monit. 2019;21(25):5408–17.CrossRef
21.
Wei J, Yang P, Huang Q, et al. Proximal versus total gastrectomy for proximal gastric cancer: a Surveillance, Epidemiology, and End Results Program database analysis. Future Oncol. 2021;17(10):1185–95.CrossRef
22.
Bhangu A, Brown G, Nicholls RJ, et al. Survival outcome of local excision versus radical resection of colon or rectal carcinoma: a Surveillance, Epidemiology, and End Results (SEER) population-based study. Ann Surg. 2013;258(4):563–71.CrossRef
23.
Ozkan EE. Radiotherapy for gastrointestinal stromal tumors. Chin Med J. 2018;131(2):235–40.CrossRef
24.
Gatto L, Nannini M, Saponara M, et al. Radiotherapy in the management of gist: state of the art and new potential scenarios. Clin Sarcoma Res. 2017;7(1):1–7.CrossRef
Metadata
Title
Survival outcome of local vs. radical excision in rectal gastrointestinal stromal tumor: a SEER database analysis
Authors
Jianchang Wei
Junbin Zhong
Zhuanpeng Chen
Qing Huang
Fang Wei
Qiang Wang
Jie Cao
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2022
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-022-01485-3

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