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Journal of Cancer Research and Clinical Oncology

Published in:

23-09-2023 | Radiotherapy | Research

Evaluation of survival outcome and prognostic factors for oral cavity cancer treated with volumetric arc therapy

Authors: Himanshu Mishra, Shreya Singh, Ritusha Mishra, Ankita Pandey, Abhijit Mandal, Ekta Prakash, Ganeshkumar Patel, Manav Shah, Tej Bali Singh

Published in: Journal of Cancer Research and Clinical Oncology | Issue 19/2023

Abstract

Purpose

This study aimed to evaluate the survival outcomes and identify prognostic factors for patients with oral cavity cancer (OCC) who underwent adjuvant treatment with volumetric arc therapy (VMAT) using simultaneous integrated boost (SIB).

Methods

Data was collected for post-operated patients of carcinoma of oral cavity who received adjuvant VMAT with SIB between June 2018 and December 2022. The data was entered and analyzed using SPSS software version 20.0. Survival rates were estimated using Kaplan Meier method. To determine survival difference between the groups, log rank test was used. Multivariate analyses were performed with Cox proportional hazard model and p value < 0.05 was considered as significant.

Results

A total of 178 patients were included in the study. The median follow-up period was 26 months (range 3–56 months). The 3-year OS, DFS, and LRC rates were 78% (95% CI 77–79%), 76% (95% CI 74–77%), and 81% (95% CI 80–82%), respectively. Univariate analysis identified age ≥ 50 years, lymph node involvement, extracapsular extension (ECE), and N2–N3 disease as significant adverse prognostic factors for OS, DFS, and LRC. Multivariate analysis confirmed age ≥ 50 years and nodal involvement as independent predictors of worse OS, DFS, and LRC. Additionally, ECE independently affected OS and DFS.

Conclusion

Adjuvant treatment with VMAT using SIBin patients with OCC is effective. Age and nodal involvement had significant impact on LRC, DFSand OS while ECE on DFSand OS.

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Title: Evaluation of survival outcome and prognostic factors for oral cavity cancer treated with volumetric arc therapy
Authors: Himanshu Mishra
Shreya Singh
Ritusha Mishra
Ankita Pandey
Abhijit Mandal
Ekta Prakash
Ganeshkumar Patel
Manav Shah
Tej Bali Singh
Publication date: 23-09-2023
Publisher: Springer Berlin Heidelberg
Keyword: Radiotherapy
Published in: Journal of Cancer Research and Clinical Oncology / Issue 19/2023
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-023-05397-4

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