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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 9/2020

Open Access 01-09-2020 | Radiotherapy | Head and Neck

Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity

Authors: Shuwei Chen, Zhu Lin, Jingtao Chen, Ankui Yang, Quan Zhang, Chuanbo Xie, Xing Zhang, Zhongyuan Yang, Wenkuan Chen, Ming Song

Published in: European Archives of Oto-Rhino-Laryngology | Issue 9/2020

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Abstract

Purpose

Whether or not young patients with squamous cell carcinoma of oral cavity (OC-SCC) have a difference in prognosis remains a controversy. This study aimed to analyze the clinical characteristics and difference of survival rates between adult patients less than 40 years of age and those 40 years of age and older.

Methods

A retrospective analysis was conducted using the database of patients diagnosed with OC-SCC between 1990 and 2013 in the Sun Yat-sen University Cancer Center, but patients older than 85 years, younger than 18 years, or died within 6 months of diagnosis were excluded. Patients were categorized into two groups: the young group (< 40 years of age) and the older group (≥ 40 years of age). Cox regression, survival and subgroups analyses were performed. The primary endpoints included the rates of 5-year overall survival (OS) and disease-specific survival (DSS).

Results

A total of 1902 OC-SCC patients were identified. The percentage of female in the young group was significantly higher than that in the older group (40.27% vs 31.03%, p < 0.001). This study failed to find the difference in TNM classification or tumor stage between the two groups (p > 0.05). The young group was more likely to receive adjuvant radiotherapy and/or chemotherapy (42.48% vs 26.91%, p < 0.001). The 5-year OS rate (71% vs. 57%, p < 0.001) and DSS rate (72% vs 58%, p < 0.001) in patients under 40 years were significantly higher than those for the older group.

Conclusion

Our findings suggested that OC-SCC in younger patients did not present at a more advanced stage. In addition, young age is an independent predictor for better survival.
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Metadata
Title
Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity
Authors
Shuwei Chen
Zhu Lin
Jingtao Chen
Ankui Yang
Quan Zhang
Chuanbo Xie
Xing Zhang
Zhongyuan Yang
Wenkuan Chen
Ming Song
Publication date
01-09-2020
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 9/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-020-05963-3

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