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Strahlentherapie und Onkologie

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01-02-2013 | Original article

Radiotherapy for achillodynia

Results of a single-center prospective randomized dose-optimization trial

Authors: PD Dr. O.J. Ott, C. Jeremias, U.S. Gaipl, B. Frey, M. Schmidt, R. Fietkau

Published in: Strahlentherapie und Onkologie | Issue 2/2013

Abstract

Background and purpose

The aim of this study was to compare the efficacy of two different dose-fractionation schedules for radiotherapy of patients with achillodynia.

Patients and methods

Between February 2006 and February 2010, 112 consecutive evaluable patients were recruited for this prospective randomized trial. All patients underwent radiotherapy with an orthovoltage technique. One radiotherapy course consisted of 6 single fractions over 3 weeks. In case of insufficient remission of pain after 6 weeks, a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. The endpoint was pain reduction. Pain was measured before, right after, and 6 weeks after radiotherapy with a visual analogue scale (VAS) and a comprehensive pain score (CPS).

Results

The overall response rate for all patients was 84% directly after and 88% 6 weeks after radiotherapy. The mean VAS values before, directly after, and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 55.7 ± 21.0 and 58.2 ± 23.5 (p = 0.526), 38.0 ± 23.2 and 30.4 ± 22.6 (p = 0.076), and 35.4 ± 25.9 and 30.9 ± 25.4 (p = 0.521), respectively. The mean CPS before, directly after, and 6 weeks after treatment was 8.2 ± 3.0 and 8.9 ± 3.3 (p = 0.239), 5.6 ± 3.1 and 5.4 ± 3.3 (p = 0.756), 4.4 ± 2.6 and 5.3 ± 3.8 (p = 0.577), respectively. No statistically significant differences were found between the two single-dose trial arms for early (p = 0.366) and delayed response (p = 0.287).

Conclusion

Radiotherapy is an effective treatment option for the management of achillodynia. For radiation protection, the dose of a radiotherapy series is recommended not to exceed 3–6 Gy.

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Title: Radiotherapy for achillodynia
Results of a single-center prospective randomized dose-optimization trial
Authors: PD Dr. O.J. Ott
C. Jeremias
U.S. Gaipl
B. Frey
M. Schmidt
R. Fietkau
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 2/2013
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0240-y

At a glance: The STEP trials

Springer Medicine

Radiotherapy for achillodynia

Results of a single-center prospective randomized dose-optimization trial

Abstract

Background and purpose

Patients and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background and purpose

Patients and methods

Results

Conclusion

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