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Strahlentherapie und Onkologie

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01-02-2013 | Case study

Multiple malignancies in a single patient

A glimpse into 30 years of interdisciplinary oncology

Authors: Dr. B. Berger, MD, M. Bamberg, D. Zips, T. Schlunk

Published in: Strahlentherapie und Onkologie | Issue 2/2013

Abstract

We report on an 83-year-old woman who suffered from seven manifestations of at least five different nonmetastasizing malignancies during a period spanning more than three decades. Although suspected, an inherited genetic tumor syndrome could not be detected. This patient history exemplifies the development of interdisciplinary oncology and specifies the success but also the risks of intensified locoregional treatments. In particular, radiation oncologists routinely have to perform a risk–benefit analysis, rendering their work both challenging and fascinating.

Berrington de Gonzalez A, Curtis RE, Kry SF et al (2011) Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries. Lancet Oncol 12:353–360CrossRef

Chiang AC, Massague J (2008) Molecular basis of metastasis. N Engl J Med 359:2814–2823PubMedCrossRef

Clarke M, Collins R, Darby S et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366:2087–2106PubMed

Colombo N, Preti E, Landoni F et al (2011) Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 22(Suppl 6):vi35–vi39PubMedCrossRef

Eich HT, Stepien A, Zimmermann C et al (2011) Neoadjuvant radiochemotherapy and surgery for advanced rectal cancer: prognostic significance of tumor regression. Strahlenther Onkol 187:225–230PubMedCrossRef

Foulkes WD (2008) Inherited susceptibility to common cancers. N Engl J Med 359:2143–2153PubMedCrossRef

Lynch HT, Chapelle A de la (2003) Hereditary colorectal cancer. N Engl J Med 348:919–932PubMedCrossRef

Marnitz S, Kohler C (2012) Current therapy of patients with endometrial carcinoma. A critical review. Strahlenther Onkol 188:12–20PubMedCrossRef

Nestle-Kramling C, Bolke E, Budach W et al (2011) Hemangiosarcoma after breast-conserving therapy of breast cancer: report of four cases with molecular genetic diagnosis and literature review. Strahlenther Onkol 187:656–664PubMedCrossRef

10.

Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740PubMedCrossRef

11.

Talbot LJ, Bhattacharya SD, Kuo PC (2012) Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies. Int J Biochem Mol Biol 3:117–136PubMed

12.

Umar A, Boland CR, Terdiman JP et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96:261–268PubMedCrossRef

13.

Winkler J, Zipp L, Knoblich J, Zimmermann F (2012) Simultaneous neoadjuvant radiochemotherapy with capecitabine and oxaliplatin for locally advanced rectal cancer: treatment outcome outside clinical trials. Strahlenther Onkol 188:377–382PubMedCrossRef

14.

Yang JC, Chang AE, Baker AR et al (1998) Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16:197–203PubMed

Title: Multiple malignancies in a single patient
A glimpse into 30 years of interdisciplinary oncology
Authors: Dr. B. Berger, MD
M. Bamberg
D. Zips
T. Schlunk
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 2/2013
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0261-6

At a glance: The STEP trials

Springer Medicine

Multiple malignancies in a single patient

A glimpse into 30 years of interdisciplinary oncology

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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