Top

Published in:

01-02-2020 | Literatur kommentiert

Radiotherapie versus transorale roboterassistierte Chirurgie in der Primärtherapie des Oropharynxkarzinoms: Randomisierung entscheidet

Authors: Dr. med. Alexander Fabian, Dr. med. David Krug

Published in: Strahlentherapie und Onkologie | Issue 2/2020

Auszug

Die optimale Therapie des Oropharynxkarzinoms ist Fragestellung zahlreicher aktueller Studien. Dies liegt an der steigenden Inzidenz, insbesondere aufgrund HPV-positiver (humane Papillomviren) Tumoren mit deutlich besserer Prognose. In den Frühstadien kommen eine primäre Radio(chemo)therapie (R(C)T) sowie die Operation (OP) als Therapieverfahren in Betracht. Ein randomisierter Vergleich zwischen primär radiotherapeutischem oder chirurgischem Vorgehen bestand bislang jedoch noch nicht. Dies untersuchte die ORATOR-Studie. …

Cracchiolo JR, Baxi SS, Morris LG, Ganly I, Patel SG, Cohen MA et al (2016) Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features: National Cancer Data Base. Cancer 122(10):1523–1532CrossRef

Monnier Y, Simon C (2015) Surgery versus radiotherapy for early oropharyngeal tumors: a never-ending debate. Curr Treat Options Oncol 16(9):42CrossRef

Yeh DH, Tam S, Fung K, MacNeil SD, Yoo J, Winquist E et al (2015) Transoral robotic surgery vs. radiotherapy for management of oropharyngeal squamous cell carcinoma—a systematic review of the literature. Eur J Surg Oncol 41(12):1603–1614CrossRef

Holsinger FC, Ferris RL (2015) Transoral endoscopic head and neck surgery and its role within the multidisciplinary treatment paradigm of oropharynx cancer: robotics, lasers, and clinical trials. J Clin Oncol 33(29):3285–3292CrossRef

Melamed A, Rauh-Hain JA, Ramirez PT (2019) Minimally invasive radical hysterectomy for cervical cancer: when adoption of a novel treatment precedes prospective, randomized evidence. J Clin Oncol. https://doi.org/10.1200/JCO.19.01164 CrossRefPubMed

Noronha V, Joshi A, Patil VM, Agarwal J, Ghosh-Laskar S, Budrukkar A et al (2018) Once-a-week versus once-every-3-weeks cisplatin chemoradiation for locally advanced head and neck cancer: a phase III randomized noninferiority trial. J Clin Oncol 36(11):1064–1072CrossRef

Asher SA, White HN, Kejner AE, Rosenthal EL, Carroll WR, Magnuson JS (2013) Hemorrhage after transoral robotic-assisted surgery. Otolaryngol Head Neck Surg 149(1):112–117CrossRef

Parhar HS, Gausden E, Patel J, Prisman E, Anderson DW, Durham JS et al (2018) Analysis of readmissions after transoral robotic surgery for oropharyngeal squamous cell carcinoma. Head Neck 40(11):2416–2423CrossRef

Dhanireddy B, Burnett NP, Sanampudi S, Wooten CE, Slezak J, Shelton B et al (2019) Outcomes in surgically resectable oropharynx cancer treated with transoral robotic surgery versus definitive chemoradiation. Am J Otolaryngol 40(5):673–677CrossRef

Title: Radiotherapie versus transorale roboterassistierte Chirurgie in der Primärtherapie des Oropharynxkarzinoms: Randomisierung entscheidet
Authors: Dr. med. Alexander Fabian
Dr. med. David Krug
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 2/2020
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-019-01567-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Radiotherapie versus transorale roboterassistierte Chirurgie in der Primärtherapie des Oropharynxkarzinoms: Randomisierung entscheidet

Auszug

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Auszug

Please log in to get access to this content

Other articles of this Issue 2/2020

Tumor regression during radiotherapy for non-small cell lung cancer patients using cone-beam computed tomography images

Pulmonary function changes following helical tomotherapy in patients with inoperable, locally advanced non-small cell lung cancer

A novel approach to SBRT patient quality assurance using EPID-based real-time transit dosimetry

Image-based lung functional radiotherapy planning for non-small cell lung cancer

De-escalated radiotherapy for indolent primary cutaneous B-cell lymphoma

Timing of thoracic radiotherapy is more important than dose intensification in patients with limited-stage small cell lung cancer: a parallel comparison of two prospective studies