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European Archives of Oto-Rhino-Laryngology

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01-01-2018 | Laryngology

Radiological tumor thickness as a risk factor for local recurrence in early glottic cancer treated with laser cordectomy

Authors: Ho-Jin Son, Yoon Se Lee, Ja Yoon Ku, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2018

Abstract

Objectives

Despite the excellent prognosis of early glottic cancer (T1–T2), the significance of preoperatively measured tumor thickness has not been elucidated. We evaluated the role of tumor thickness measured using computed tomography (CT) as a predictive factor for recurrence of early glottic cancer after transoral laser microsurgery (TLM).

Methods

The medical records of 134 patients who were diagnosed with early glottic squamous cell carcinoma and underwent TLM were reviewed. Age, sex, clinical stage, preoperative biopsy, anterior commissure involvement, CT findings, recurrence, and overall survival were evaluated.

Results

Seventy-three patients (54 T1a, 2 T1b, and 17 T2) were enrolled. Tumor thickness on pathology increased proportionally with increased tumor thickness on CT. The recurrence-free survival (RFS) and overall survival rates were 82.2 and 91.2%, respectively. Upon univariate analysis, RFS was affected by the type of cordectomy, tumor differentiation, margin involvement, anterior commissure involvement, impaired vocal fold mobility, and tumor thickness (> 4 mm) on CT scan (all p < 0.01). Among the relevant covariates, an involved or close resection margin [hazard ratio (HR) 19.2; 95% confidence interval (CI) 3.5–105.6; p < 0.01], impaired vocal cord mobility (HR 8.5; 95% CI 1.45–49.2; p = 0.02), and pathological tumor thickness (> 4 mm) (HR 6.0; p = 0.02) were predictive of RFS.

Conclusion

Tumor thickness may be another predictive factor for recurrence in early glottic cancer. Before TLM, reviewing the extent of tumor thickness will help to improve local control in cases of early glottic cancer.

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Title: Radiological tumor thickness as a risk factor for local recurrence in early glottic cancer treated with laser cordectomy
Authors: Ho-Jin Son
Yoon Se Lee
Ja Yoon Ku
Jong-Lyel Roh
Seung-Ho Choi
Soon Yuhl Nam
Sang Yoon Kim
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-017-4793-3

At a glance: The STEP trials

Springer Medicine

Radiological tumor thickness as a risk factor for local recurrence in early glottic cancer treated with laser cordectomy

Abstract

Objectives

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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