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Published in: Pediatric Radiology 2/2012

01-02-2012 | Case Report

Radiologic features of NUT midline carcinoma in an adolescent

Authors: Daniel G. Rosenbaum, Julie Teruya-Feldstein, Anita P. Price, Paul Meyers, Sara Abramson

Published in: Pediatric Radiology | Issue 2/2012

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Abstract

We present a case of NUT midline carcinoma (NMC) mimicking lymphoma in an adolescent boy, with attention to multidetector CT appearance and pattern of metastasis on [F-18]2-fluoro-2-deoxyglucose positron emission tomography (FDG PET/CT). Few case reports have focused on the imaging characteristics of this rare tumor in the pediatric imaging literature. A newly described but increasingly recognized disease entity, NMC should enter the differential of pediatric midline tumors displaying particularly aggressive characteristics on imaging.
Literature
1.
go back to reference French CA, Miyoshi I, Kubonishi I et al (2003) BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res 63:304–307PubMed French CA, Miyoshi I, Kubonishi I et al (2003) BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res 63:304–307PubMed
2.
go back to reference French CA, Kutok JL, Faquin WC et al (2004) Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol 22:4135–4139PubMedCrossRef French CA, Kutok JL, Faquin WC et al (2004) Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol 22:4135–4139PubMedCrossRef
3.
go back to reference Nelson BA, Lee EY, French CA et al (2010) BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings. J Thorac Imaging 25:W93–W96CrossRef Nelson BA, Lee EY, French CA et al (2010) BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings. J Thorac Imaging 25:W93–W96CrossRef
5.
go back to reference Niederkohr RD, Cameron MJ, French CA (2011) FDG PET/CT imaging of NUT midline carcinoma. Clin Nucl Med 36:e124–e126PubMedCrossRef Niederkohr RD, Cameron MJ, French CA (2011) FDG PET/CT imaging of NUT midline carcinoma. Clin Nucl Med 36:e124–e126PubMedCrossRef
6.
go back to reference Teo M, Crotty P, O’Sullivan M et al (2011) NUT midline carcinoma in a young woman. J Clin Oncol 29:e336–e339PubMedCrossRef Teo M, Crotty P, O’Sullivan M et al (2011) NUT midline carcinoma in a young woman. J Clin Oncol 29:e336–e339PubMedCrossRef
7.
go back to reference Haack H, Johnson LA, Fry CJ et al (2009) Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol 33:984–991PubMedCrossRef Haack H, Johnson LA, Fry CJ et al (2009) Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol 33:984–991PubMedCrossRef
8.
go back to reference French CA, Ramirez CL, Kolmakova J et al (2008) BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 27:2237–2242PubMedCrossRef French CA, Ramirez CL, Kolmakova J et al (2008) BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 27:2237–2242PubMedCrossRef
Metadata
Title
Radiologic features of NUT midline carcinoma in an adolescent
Authors
Daniel G. Rosenbaum
Julie Teruya-Feldstein
Anita P. Price
Paul Meyers
Sara Abramson
Publication date
01-02-2012
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 2/2012
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-011-2288-8

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